The Morning Dose #29: Anabolic Fish Oil, Andrew Huberman, and Peptides for Weight Gain?

In this week’s edition of The Morning Dose:

FDA Semaglutide Investigation Update

What Andrew Huberman Got Wrong About Peptides

Peptide Spotlight: Lenomorelin

 Research Spotlight: The Impact of Omega-3s on Muscle and Strength

Does TRT Reduce Bone Fractures?

Let’s inject this.

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 FDA Semaglutide Investigation Update

Last week, we told you that the FDA was investing reports of suicidal ideation and hair loss caused by weight loss peptides like Wegovy and Ozempic.

Well, we have some good news to share. The FDA has officially announced that they found no relationship between weight loss peptides and suicidal ideation, and no clinical studies showed any connection between weight loss peptides and suicidal thoughts.

We weren’t assuming that people were going to stop using these peptides based on preliminary reports, but still, this is good news.

Official Press Release

 What Andrew Huberman Got Wrong About Peptides

While Andrew Huberman has become a household name in the world of health, fitness, and all things science, this was an interesting video reaction from Peptide Buddy on Andrew Huberman’s discussion about BPC-157 with Joe Rogan.

As it turns out, Huberman’s knowledge of peptide isn’t what you’d expect from someone with so much scientific knowledge…

Check out the video to see what we mean.

 Peptide Spotlight: Lenomorelin

We’ve covered a lot of peptides in our weekly spotlights, including peptides that reduce hunger, improve muscle mass, support cognitive function, and more.

This week, we’re looking at a very unique peptide, Lenomorelin, which increases your appetite.

This peptide is also known as ghrelin, which is a hormone secreted by our bodies that regulates appetite. When ghrelin increases, so does your hunger, leading you to eat more food and gain more weight.

While many people struggle to lose weight and are more interested in weight loss peptides, gaining weight is a real challenge for countless individuals.

In particular, I’m talking about building muscle mass with healthy food–anyone could eat a pizza every night and start to gain body fat.

However, when it comes to muscle, certain types of people have fast metabolisms and low appetites, making it very difficult to gain lean mass. We typically call them “hardgainers.”

Walk into any gym, and you’ll no find no shortage of people who are desperately trying to bulk and gain weight, but simply can’t seem to eat enough. I’ve heard many people say they feel like they’re force feeding themselves and feel physically uncomfortable, but just can’t eat enough food to build muscle.

This is where Lenomorelin comes in, as it increases your appetite to help you eat more, and gain weight.

If you’re a hardgainer or bodybuilder who simply can’t seem to put on any weight, no matter how hard you try, this may be the exact peptide you need.

To learn more, be sure to read our complete guide Lenomorelin.

 Research Spotlight: The Impact of Omega-3s on Muscle and Strength

Health-conscious individuals have long used omega-3 supplements to improve their health, as they’ve been shown to be beneficial for improving cardiovascular health, reducing inflammation, improving cognitive function, and much more.

And now we may be discovering one more benefit of the omega-3s found in fish oil–improve strength performance.

A brand new meta-analysis looked at 14 different studies to see if fish oil had any impact on strength and muscle mass.

The researchers found a small, but statistically significant impact on muscle strength, and a small impact on muscle growth.

What’s interesting is that these benefits were shown regardless of age, and even participants who weren’t regularly strength training were impacted.

Based on the typical actions of fish oil, we wouldn’t necessarily expect to see anabolic effects and muscular growth, but it’s quite interesting to see that strength improved, with or without strength training.

Now, we’re not saying that you should stop lifting, but we ARE saying that this is just one more reason to make high-quality fish oil a regular part of your supplement routine.

There are plenty of proven benefits that will improve your health, and increased strength is just one more benefit you’ll enjoy.

Does TRT Reduce Bone Fractures?

We’re huge fans of TRT when it’s clinically needed, which is why we always encourage both men and women to stay on top of their hormonal health.

These days, it’s easier than ever to get your bloodwork checked, thanks to trusted providers like our friends at FountainTRT (Morning Dose readers can access $35 bloodwork), so there’s no reason you should be living your life with sub-optimal hormones.

While everyone should have optimal testosterone levels, TRT is not a magic bullet, and you still need to make the right lifestyle choices and take care of your health.

There’s a new study making the rounds from the New England Journal of Medicine that investigated whether restoring healthy testosterone levels could reduce bone fractures in men, and the results were a bit misleading.

Testosterone treatment in men with low T improves bone density, but interestingly, the study found that men on TRT were more likely to experience bone fractures.

The study looked at 5,204 men who had clinically low testosterone (below 300ng/dl in two fasting tests), and put half the group on a testosterone cream, with the other half on a placebo.

After a three-year follow-up, there were more fractures in the TRT group than in the placebo group. 

If you see that headline, don’t be alarmed.

Overall, the total number of fractures was still relatively low. Both groups had about 2,600 men in the study, and there were 91 fractures in the TRT group and 64 in the placebo group.

In other words, 3.5% of men in the TRT group had experienced fractures, while only 2.46% in the placebo group had fractures.

That’s a difference of just over one percent, but still a relatively small percentage.

And this certainly doesn’t mean that testosterone reduces bone density. The fractures could have been caused by any number of things.

Still, it’s a good reminder that TRT is NOT a magic bullet that will make you invincible and solve all of your problems. Lifestyle choices still have the biggest impact.

If you’re worried about bone density, regular strength training along with adequate calcium intake is still the way to go, as this improves bone density and strength over time.

Testosterone therapy in clinically low individuals enhances a healthy lifestyle, but it’s not a replacement for proper nutrition and regular exercise.

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