Dulaglutide improved muscle strength and attenuated muscle loss in disuse condition. Ten-week-old C57BL/6 male mice were subjected to spiral wire immobilization for 4 d and administrated dulaglutide (Trulicity, 600 µg/kg, subscutaneous). Mice were maintained for additional 7 d. (A) Grip strength...
Skeletal muscle atrophy is defined as a reduction of muscle mass caused by excessive protein degradation. However, the development of therapeutic interventions is still in an early stage. Although glucagon‐like peptide‐1 receptor (GLP‐1R) agonists, such as exendin‐4 (Ex‐4) and dulaglutide, are...
Eriobotrya Japonica extract(Loquat) is a natural anabolic/anti-catabolic that work by manipulating certain genes that are responsible for processes like building/wasting muscle. Ursolic acid is one of the many bioacitves in Loquat that has been shown to increase muscle strength. Loquat activates...
Recombinant Human LR3 Insulin-like Growth Factor-1 LR3-IGF1 Is What You Want To Purchase!
Yes They are sold lyophilized as well as reconstituted straight from manufactors like Sigma and such.
Stay away from The Synthetic garbage
The Insulin-like growth factors (IGFs) are mitogenic...
theguerrillachemistA buddy of mine @ergogenic_health who knows a lot about botanicals and physiology sent me this study which is very interesting. Researchers gave mice Lion’s Mane extract(extracted in either ethanol or hexane) and measured its affect on PPAR delta(peroxisome...
AbstractHyaluronic acid (HA) is a component of the extracellular matrix (ECM) in most vertebrate tissues and is thought to play a significant role during development, wound healing, and regeneration. In vitro studies have shown that HA enhances muscle progenitor cell recruitment and inhibits...
AbstractSkin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal...
BackgroundCholesterol is mainly synthesised in liver and the rate-limiting step is the reduction of 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) to mevalonate, a reaction catalysed by HMG-CoA reductase (HMGCR). There is a comprehensive body of evidence documenting that anabolic-androgenic...
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Androgen Receptors Explained
by Anthony Roberts
One of the most peculiar things about the steroid community, and in particular, the online steroid community, is the ongoing level of misinformation about the androgen receptor and the...
Optimization of production of recombinant human growth hormone in Escherichia coli
Background:Human growth hormone (hGH) is a single-chain polypeptide that participates in a wide range of biological functions such as metabolism of proteins, carbohydrates and lipids as well as in growth...
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Benefits of ClenbuteralBuild Muscle & Burn Fat at the Same Time
Clenbuterol is a popular drug used by bodybuilders and athletes that belongs to a class of compounds known as beta-agonists that bind to the beta-adrenergic receptor embedded in the cell membrane— turning on cellular signaling...
GENE EXPRESSION IN TENDS/COLLAGEN AFTER HEAVY AAS USE
Researchers in the European Journal of Applied Physiology examined how heavy use of the anabolic steroid Deca-Durabolin affected collagen strength in rats. The rats were separated into two groups: natural training and training with heavy...
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The role of the insulin-like growth factors in the central nervous system.D'Ercole AJ1, Ye P, Calikoglu AS, Gutierrez-Ospina G.
Author information
Abstract<abstracttext>Increasing evidence strongly supports a role for insulin-like growth factor-I (IGF-I) in central nervous system (CNS)...
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by Mike Arnold
Most bodybuilders tend to view estrogen as a fat storage hormone, but its actions on adipose tissue are not so simple. In excessive amounts it can indeed lead to body fat acquisition, but in quantities compatible with male physiology it has a positive effect on bodyfat, making it...
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