mice

Tweaking a gene makes muscles twice as strong Salk scientists and their collaborators find new avenue for treating muscle degeneration in people who can't exercise LA JOLLA, CA—An international team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural...

A few days ago a clinical trial was published stating that creatine causes cancer... Can this be true? Well, the truth is that it can’t, as stated by Dr. Richard Creider along with 29 other experts in a critique of this clinical trial. 👨🏼*🔬 Problems: ❕They used mice 🐁 in which cancerous...

A few days ago a clinical trial was published stating that creatine causes cancer... Can this be true? Well, the truth is that it can’t, as stated by Dr. Richard Creider along with 29 other experts in a critique of this clinical trial. 👨🏼*🔬 Problems: ❕They used mice 🐁 in which cancerous...

theguerrillachemist There is a fairly new area for obesity that involves an enzyme known as nicotinamide N-methyltransferase(NNMT), which is known to be unregulated in white adipose tissue. NNMT helps regulate the detoxification of certain compounds like methionine(homomethionine), via...

Unbound (bioavailable) IGF1 enhances somatic growth Understanding insulin-like growth factor-1 (IGF1) biology is of particular importance because, apart from its role in mediating growth, it plays key roles in cellular transformation, organ regeneration, immune function, development of the...

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A study just came out and yields some interesting data in mice about America’s favorite sugar additive: high-fructose corn syrup. Essentially, they used mice genetically predisposed to grow tumors in the intestines(and colon) and then either had them drink water with low concentration of HFCS or...

Synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases. ABSTRACTSynchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic...

by Matt Weik Our senses play a key role in our everyday life, and the sense of smell might actually play a role in how much weight we gain. As odd as it may sound, researchers are now looking into the possibility that if we can’t smell what we are eating, it allows us to stay leaner in the...

by Matt Weik Now, I see a whole bunch of perverts looking over at their girlfriend or wife and I can see the mouse running on the wheel in your brain. We aren’t talking about sex toys, gentlemen. At ease. We aren’t looking for you to star in your own homemade porno. What we are talking...

By Sarah Chadwell, NASM CPT The average American consumes 3,400 milligrams of salt per day far surpassing the upper end of the recommended daily allowance of 2,300 mg per day. Why? Salt can make cardboard taste good. So what’s the harm? A study published in The Journal of Clinical...

If people were made in high-tech factories instead of being born, they'd no doubt come off the assembly line with a couple of bottles of curcumin glued to the side of their butt so the product would remain defect-free. I mean, is there anything this stuff doesn't do? Curcumin started off as an...

Every week, there seems to be another story about the health benefits of running. That’s great — but what if you can’t run? For the elderly, obese or otherwise mobility-limited, the rewards of aerobic exercise have long been out of reach. Salk Institute scientists, building on earlier work that...

Tamoxifen, a selective estrogen receptor modulator, is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer. Tamoxifen is also known to have metabolic effects. A new study in The American Journal of Pathology reports that the drug also prevents obesity, fatty...

Every week, there seems to be another story about the health benefits of running. That’s great — but what if you can’t run? For the elderly, obese or otherwise mobility-limited, the rewards of aerobic exercise have long been out of reach. Salk Institute scientists, building on earlier work that...

Scientists at the Gladstone Institutes identified an FDA-approved drug that can create the elusive and beneficial brown fat. Mice treated with the drug had more brown fat, faster metabolisms, and lower body weight gain, even after being fed a high-calorie diet. The researchers say the technique...

Insulin-like growth factor-1 builds muscle (hypertrophy) and utilizes carbohydrates as fuel for energy. We characterized the metabolic profile of transgenic mice exhibiting enhanced muscle mass driven by increased mIGF-1 expression (MLC/mIGF-1). As expected, 6-month-old MLC/mIGF-1 mice were...

Very interesting! A protein called IGF-1, which is found in high levels in young people, might offer a way to prevent arteries from clogging as we age, according to early results with mice. “The body already works to remove plaque from arteries through certain types of white blood cells called...

The role of the insulin-like growth factors in the central nervous system.D'Ercole AJ1, Ye P, Calikoglu AS, Gutierrez-Ospina G. Author information Abstract<abstracttext>Increasing evidence strongly supports a role for insulin-like growth factor-I (IGF-I) in central nervous system (CNS)...

Insulin-like growth factors and their receptors in growth.D'Ercole AJ1. Author information Abstract<abstracttext>The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems...