drtbear1967
Musclechemistry Board Certified Member
theguerillachemist
Just ran across this 2014 study showing that a 50/50 combination of citrulline/arginine mix elevated plasma arginine levels and blood nitrate/nitrite levels higher than either compound alone at 2x the dose, in both rats and rabbits. Interestingly, the Citrulline/Arg blend was only more effective for the initial peak, which lasted for 60min. After that, levels of NOx and Arg were about the same in all 3 groups.
The initial increase was about 35% higher in NOx and Arg levels, which is pretty significant. Previously studies have shown that Arginine can elevate NO levels only in very high amounts, 9g and above. Worth noting that Arg has a higher affinity to the enzyme arginase vs NO synthase, and arginase breaks down Arg into orthinitine.
Researchers hypothesized that citrulline acts as an allosteric inhibitor(binds to the enzyme but not the active site, essentially changing the shape of the enzyme) of Arginase, which supports the data of higher Okasan arginine levels vs just arginine. I have not personally tried this blend, as I am a big fan of nitrates over citrulline and arginine for NO, but I will and let you guys know if it works and what doses to use.
Just ran across this 2014 study showing that a 50/50 combination of citrulline/arginine mix elevated plasma arginine levels and blood nitrate/nitrite levels higher than either compound alone at 2x the dose, in both rats and rabbits. Interestingly, the Citrulline/Arg blend was only more effective for the initial peak, which lasted for 60min. After that, levels of NOx and Arg were about the same in all 3 groups.
The initial increase was about 35% higher in NOx and Arg levels, which is pretty significant. Previously studies have shown that Arginine can elevate NO levels only in very high amounts, 9g and above. Worth noting that Arg has a higher affinity to the enzyme arginase vs NO synthase, and arginase breaks down Arg into orthinitine.
Researchers hypothesized that citrulline acts as an allosteric inhibitor(binds to the enzyme but not the active site, essentially changing the shape of the enzyme) of Arginase, which supports the data of higher Okasan arginine levels vs just arginine. I have not personally tried this blend, as I am a big fan of nitrates over citrulline and arginine for NO, but I will and let you guys know if it works and what doses to use.
