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For centuries, humankind has been on a quest for the fountain of youth - a way to reverse the relentless effects of aging. Over the years, a number of supposed time-defying products have emerged onto the market. One supplement that has been receiving a lot of attention lately is nicotinamide mononucleotide, a.k.a. NMN anti-aging supplements.
NMN's ability to boost the body's levels of the coenzyme NAD+ may be able to bring about a whole host of health benefits. These include increasing energy output, enhancing brain function, and preventing age-related changes in gene expression.
To prepare for this article, I've gone deep into the NMN supplement market to find the nine best NMN supplements currently being sold. As well as providing personal reviews of each of these products, I'll also delve into the research-backed benefits of taking an NMN supplement and provide you with a comprehensive buyer's guide to help you sort out the best from the rest.
Wonderfeel
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS Sublingual Pick
Renue By Science
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS XR Pick
Nootropics Depot
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
**There may be affiliate links in this post where we might receive a small commission on purchases you make. We only recommend products we think you will find valuable.**
9 Best NMN Supplements:
Overall Best NMN Supplement: Wonderfeel Youngr NMN
Best Sublingual NMN Supplement: Renue By Science NMNs
Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
Best Powder NMN Supplement: Double Wood NMN Powder
Best Budget NMN Supplement: BulkSupplements NMN
Best Liposomal NMN Supplement: Renue By Science Lipo NMN
Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
Best Liquid NMN Supplement: Quicksilver Scientific
1. Overall Best NMN Supplement: Wonderfeel Youngr NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Wonderfeel Youngr NMN, as the name suggests, is geared toward promoting longevity. As well as providing you with 900 mg of NMN per serving, you also get a range of other compounds that have been shown to work synergistically alongside NMN to enhance its effects. These include resveratrol, ergo, hydroxytyrosol, and vitamin D3.
The large dose of NMN that you get in this supplement has been specially formulated by a Harvard MD for enhanced bioavailability. So, as well as giving you more NMN than any other brand I came across, it also has greater absorbency so that more of the active ingredient gets into your body's cells.
There is no gluten, soy, dairy, or fish in this supplement. That means that it is vegan-friendly, It's also non-GMO, and does not contain any preservatives. A rice hull powder has been added to improve stabilization. I've recommended this NMN supplement to a few of my personal training clients, and none of them have had issues like stomach upset or bloating. I'm pretty sure this is due to the enhanced stabilization that comes from the rice hull powder.
Each container of Wonderfeel Youngr NMN contains 60 capsules. With a daily recommended dosage of two capsules, that's enough for a 30-day supply. At just under $90 for a one-time purchase, this is a pretty expensive supplement. However, you can sign up for a subscription, which knocks off $15.
Pros
+High NMN dosage
+Excellent absorbency
+Vegan friendly
Cons
-Quite expensive
Overall Best NMN Supplement
Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend...
2. Best Sublingual NMN Supplement: Renue By Science NMNs
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue by Science provides a range of pharmaceutical-grade NMN supplements in a number of different forms. This company is committed to delivering a high level of absorbency with its products. That is a big deal because many supplements have a very poor rate of absorbency in the body.
The sublingual NMN supplement that Renue offers provides excellent absorption. When I took it under my tongue, I felt the effects in my system a lot faster than when I took a capsule form with similar ingredients. That means that you get a lot more potency for a lower dosage.
Unlike many sublingual supplements, I didn't experience any nasty aftertaste with Renue By Science NMNs. In fact, it has a natural lemonade flavor which I enjoyed, and has an easy-to-absorb texture.
The product also includes natural additives to increase absorption. It's completely free of preservatives and artificial flavors and, as with all Renue by Science products, is 3rd party tested for purity and potency.
Each NMN tablet contains 125 mg of NMN, and you get 240 tablets in each container. The serving size is two tablets, providing you with a 3-month supply.
Renue by Science NMNs is well-priced and, as a bonus, provides free shipping on domestic US orders.
Pros
+Fast absorbency
+Pleasant lemonade taste
+250 mg NMN per serving
Cons
-Does not offer a money-back guarantee
Best Sublingual NMN Supplement
These tablets can be chewed or used sublingually (under the tongue). A percentage of the NMN is absorbed directly to the bloodstream and is available to cells...
3. Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Nootropics Depot NMN Tablets provide a slow release of the NMN into your system. This sustained release provides a longer-lasting effect. This may mean you don't have to take the supplement as often as a faster-release alternative.
Slow-release NMN supplements may also have fewer side effects, according to some research, as well as better absorption, utilization, and the ability to maintain more stable blood sugar levels.
You get 125 mg of NMN with each capsule of Nootropics NMN tablets. That is a relatively low dosage but may be compensated for by the increased absorbency. Each tablet has an enteric coating to further increase the bioavailability. This coating prevents the disintegration of the supplement in the stomach, allowing it to reach the small intestine fully intact.
Nootropics Depot offers this supplement in either a 30 or 60-count jar. The recommended daily dosage is one capsule.
Pros
+Slow-release form of NMN
+Increased absorbency
+Enteric coating to prevent disintegration in the stomach
Cons
-Relatively low NMN dose
Best Slow-Release NMN Supplement
The enteric coating on these tablets prevents disintegration of the NMN tablet in the stomach and instead delays tablet disintegration until the NMN tablet reaches the small intestines...
4. Best Powder NMN Supplement: Double Wood NMN Powder
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Double Wood NMN Powder is as pure and simple as it gets. Every serving provides you with 1 gram of NMN powder - and nothing else. With 30 grams in each container, you've got enough for a one-month supply.
This product is vegan friendly and is non-GMO, preservative, gluten, filler, and additive free. Even though the ingredient label gives the dosage as 1 gram, the website recommends breaking that up into several smaller dosages rather than taking it all at once. It is claimed that, due to the short half-life of NMN, taking 3-4 four dosages spaced a couple of hours apart, you will be better able to elevate NAD+ levels.
This powder does a decent job of mixing, but you may be left with a bit of residue if you're just mixing it with a spoon in your glass of water.
One thing I especially appreciate about Double Wood as a supplement manufacturer is that it is very transparent about its products. The company employs a 3rd party laboratory to carry out testing for purity and potency. You can even check the 3rd party testing details on the official website.
Pros
+3rd party tested
+1 gram NMN per serving
+Vegan friendly
Cons
-Doesn't mix overly well
-No added ingredients
Best Powder NMN Supplement
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound that is in small amounts in the human body as well as some foods. NMN is orally bioavailable...
5. Best Budget NMN Supplement: BulkSupplements NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
BulkSupplements have created a thriving business by supplying simple, no-frills health and fitness supplements with basic packaging at a budget price and with top quality. Their NMN supplement is a good example of that business model in action.
I recommend BulkSupplements products to my personal training clients more than any other brand. I do so because, after many years of using their products, I have absolute confidence in the purity and effectiveness of their supplements.
The powder in this NMN supplement mixes well to give you a smooth consistency when you drink it. The recommended serving size for BulkSupplements NMN is 250 mg. With each bag providing you with 10 grams, that gives you enough for 40 servings. You can also buy it in larger, bulk amounts, so long as they are not sold out.
Pros
+250 mg per serving
+Trusted brand
+Very cost-effective
Cons
-No added ingredients
Best Budget NMN Supplement
BulkSupplements NMN is a pure form of the nutrient nicotinamide mononucleotide (NMN). NMN is a precursor to NAD+, which is essential for cellular health and anti-aging...
6. Best Liposomal NMN Supplement: Renue By Science Lipo NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue By Science Lipo NMN is a powdered form of NMN that contains the liposomal form of the compound. The liposomal delivery system is a technique for supplying the body with nutrients in a way that improves their absorption and bioavailability.
Liposomes are tiny, spherical particles with a lipid bilayer, which resembles the composition of cell membranes. By joining with cell membranes, thanks to this structure, liposomes can transfer their contents directly into the cells.
There are 500 mg of NMN in every serving of Renue By Science Lipo NMN, with a serving being two capsules. Renue uses LIPO Caps™ with this product. These patented caps involve filling liposomes with nanoparticles that are subsequently freeze-dried to eliminate the aqueous phase. This ensures optimal stability and bioavailability while also guarding the ingredients against deterioration.
Pros
+500 mg NMN per serving
+Liposomal delivery system
+LIPO Caps™ for enhanced bioavailability
+Mixes well
Cons
-No added ingredients
Best Liposomal NMN Supplement
LIPO NMN features proprietary, powder-based liposomes that protect NMN from digestive enzymes & carry it into the bloodstream for targeted systemic delivery...
7. Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Peak Performance NMN + Resveratrol combines 150 mg of NMN with the same amount of resveratrol to supercharge the supplement's effectiveness. Both resveratrol and NMN have been demonstrated to enhance cellular regeneration and repair procedures that lessen the effects of aging. These compounds may combine to strengthen their anti-aging benefits when taken together.
Resveratrol has been demonstrated to have cardioprotective properties, while NMN may support improved blood vessel function and oxidative stress reduction. Mixing these substances may enhance cardiovascular health in general.
Resveratrol has also been shown in animal studies to enhance cognitive performance, while NMN has been found to assist brain function and repair procedures. Together, these compounds could enhance cognition in general and memory, concentration, and focus in particular.
Peak Performance NMN + Resveratrol is 3rd party tested for purity and potency. It is vegan and allergy free. It is also free of soy, milk, egg, shellfish, corn, wheat & peanuts. It contains no gluten or preservatives. The supplement is manufactured under GMP regulations and USA Standards.
The serving size for Peak Performance NMN + Resveratrol is one vegan capsule, and there are 30 capsules per container.
Pros
+NMN + Resveratrol
+Increased absorbency
+3rd party tested
Cons
-The company is not NSF certified
Best NMN + Resveratrol Supplement
Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs...
8. Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Prohealth Longevity NMN Pro provides you with 300 mg of NMN per two-capsule serving. According to the manufacturer, this is the only NMN supplement that has been clinically proven to boost NAD+ levels in humans. In a study, NAD+ levels were increased by 38% in 60 days - the equivalent of a 12-year reversal.
Prohealth has been selling top-quality supplements for 34 years, having established a reputation for quality, purity, and value. I have personally used their supplements for many years and have always been very pleased with the effectiveness of their supplements. The company has an A+ rating with the Better Business Bureau.
Every batch of Prohealth Longevity NMN Pro is 3rd party tested for potency and purity. All 3rd party lab certificates of analysis are publicly posted on the company website. The supplement is manufactured in an FDA-registered, GMP-certified facility in the USA.
Pros
+300 mg of NMN per serving
+3rd party tested
+Confirmed to be effective in a clinical study
+Vegan friendly
Cons
-Reported to induce sleepiness by some reviewers
Best Absorbability NMN Supplement
ProHealth Uthever NMN: The ONLY NMN CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed double blind placebo controlled clinical study...
9. Best Liquid NMN Supplement: Quicksilver Scientific
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Quicksilver Scientific is a liquid form of NMN supplement. Taking NMN in liquid form is believed to provide the greatest absorbency. They may also allow for more precise dosing than taking a powder or capsule form of the supplement. If you have issues swallowing capsules or tablets, liquid may be the best form for you.
Every dose of Quicksilver Scientific gives you 50 mg of NMN, blended with methylation cofactors and sirtuin activators to boost its effectiveness. It includes quercetin, TMG, riboflavin, and vitamin B12, which have been shown to work with NMN to make it more active.
Quicksilver scientific claims that its products utilize the world's most advanced phospholipid delivery system. That means that the core ingredients will get into your body's cells faster.
To be honest, the taste of Quicksilver Scientific is not great. But it doesn't have very much of an aftertaste, so the unpleasantness goes away pretty quickly.
Pros
+50 mn MNM in liquid form
+Improved absorbency
+Advanced phospholipid system
Cons
-Taste is not the best
Best Liquid NMN Supplement
NAD+ Platinum is a blend of NMN, methylation cofactors and sirtuin activators. It combines the action of 3 separate products (NAD Gold, Methyl Charge and The One)...
What is NMN?
NMN stands for nicotinamide mononucleotide. The NMN molecule plays a key role in the body's production of energy. NMN is a precursor to the coenzyme NAD+ or nicotinamide adenine dinucleotide. A precursor is a compound that is needed for the body to produce another compound. NAD+ is pivotal to a range of biological processes, including metabolism, gene expression, and DNA repair.
Our bodies naturally produce NMN. However, as we age, that production declines. Supplementing with an NMN supplement can increase those levels to promote higher production of NAD+ in the body.
Supplementing with NMN has been shown to actually be better than taking an NAD+ supplement. That is because NMN molecules are much smaller and are, therefore, better able to be absorbed and utilized by the body.
Benefits of NMN:
In recent years, there has been a lot of research into the benefits of both NMN and NAD+. Here are the eight key benefits of taking an NMN supplement.
1. Increases energy
As stated, NMN is a precursor of NAD+, a coenzyme that is essential for the synthesis of cellular energy. The process by which nutrients are transformed into ATP, the energy-producing molecule for cells, involves NAD+. Supplementing with NMN may help to enhance cellular energy generation and fight fatigue by raising NAD+ levels in the body.
NMN may also assist in enhancing muscle performance and reducing exhaustion during workouts. In one study, NMN supplementation in mice enhanced endurance and decreased fatigue during physical activity.
By accelerating the body's breakdown of fats and sugars, NMN may help boost metabolism. This increases calorie burn to produce more energy.¹ ²
2. Revitalizes blood vessels
Blood flow and blood pressure are significantly influenced by endothelial cells, which line the interior of our blood arteries. A body of clinical research suggests that NMN supplementation may assist in enhancing endothelial function, which will increase blood flow and lower the risk of cardiovascular disease.
According to some studies, NMN supplementation may help to reduce inflammation in the body. Chronic inflammation is a key risk factor for cardiovascular disease. NMN may improve overall cardiovascular health by decreasing inflammation and defending blood vessels from harm.
Nitric oxide is a chemical that is important for numerous physiological functions, including controlling blood flow and blood pressure. According to some research, using NMN supplements may help to boost nitric oxide levels.
One study used a mouse model of ischemia-reperfusion injury to look at how NMN affected the heart. The study's findings—which were supported by improved blood vessel function, higher blood flow, and decreased oxidative stress—show that NMN supplementation lessened the severity of the heart injury and improved blood vessel function. According to the researchers, NMN might be useful as a therapeutic drug to enhance blood vessel function and lower cardiovascular risk.³ ?
3. Improves Memory
As we age, our bodies produce less NMN. This may contribute to age-related cognitive decline, increasing memory loss. NMN supplementation has been shown to increase mitochondrial function inside the cell. Some researchers believe that this helps with cognitive functioning.
Higher levels of NAD+ result in reduced oxidative stress. This, too, has been associated with improved cognitive performance, including better memory.
In one study, NMN's impact on brain damage caused by global cerebral ischemia in mice was examined. The researchers discovered that NMN supplementation decreased brain damage and enhanced cognitive performance, as shown by improved memory in a test of fear conditioning. The researchers hypothesized that NMN could have potential as a therapeutic drug for enhancing cognitive performance and lessening the symptoms of brain damage.?
4. Boosts metabolism
NAD+ is essential in the synthesis and utilization of cellular energy. NMN supplementation may support a healthy metabolism and the production of energy since it raises the body's levels of NAD+.
Mitochondria are the organelles in cells that produce energy through cellular respiration. An increased mitochondrial function may result in enhanced energy production and metabolism when NMN supplementation is used.
Persistent inflammation contributes to a range of diseases, including metabolic dysfunction, Type 2 diabetes, and obesity. Research shows that reducing inflammation by taking an NMN supplement may boost metabolic health.
Supplementing NMN may also increase insulin sensitivity. This could result in increased energy production.? ?
5. May Increase fertility
By promoting healthy mitochondrial function and energy production, NMN supplementation might help to improve ovarian function. Women who are suffering from ovarian function decline brought on by aging may find this to be helpful.
Oocytes, also known as egg cells, are what sperm fertilize in the womb. Oocyte quality has been seen to be improved by increased NAD+ levels. The chances of a successful conception may, therefore, increase as a result of NMN supplementation, according to research.
By harming cells and DNA, oxidative stress can cause infertility. According to some research, using NMN supplements may help women have healthier fertility and less oxidative stress.
Although the majority of studies on NMN and fertility have focused on women, several studies have suggested that NMN supplementation may also have benefits for men. According to one study, NMN supplementation may increase sperm count in mice.?
6. Repairs DNA damage
Due to its involvement in the activity of enzymes that aid in the repair of damaged DNA, NAD+ is essential for DNA repair. The activities involved in DNA repair may be supported by NMN supplementation since it raises the body's levels of NAD+.
NMN supplementation may help in improving cellular energy generation by promoting healthy mitochondrial function, which is necessary for the energy-intensive DNA repair processes. Cells that are actively mending DNA damage might benefit from this.
Because oxidative stress can harm DNA, lowering it may aid in the processes that support DNA repair. According to some studies, taking NMN supplements may help the body lower oxidative stress levels, which may support DNA repair.
One study looked at how giving NMN to animals with muscular dystrophy affected DNA damage and repair mechanisms. The researchers discovered that NMN supplementation increased DNA repair mechanisms, resulting in reduced DNA damage and enhanced muscle performance. The researchers hypothesized that NMN supplementation might have therapeutic potential for enhancing DNA repair mechanisms and minimizing DNA damage.? ¹?
7. May improve stem cell health
NAD+ has a role to play in regulating stem cell function. NMN's ability to increase NAD+ levels means that it may help improve stem cell health. The mitochondria in cells, which are key to energy production, are also necessary for stem cell health. NMN supplementation, as we have already noted, helps to improve mitochondrial activity.
There is also some evidence to imply that NMN supplementation may help to reduce cellular senescence, or aging and death, in stem cells. Other research suggests that NMN supplementation may help to improve stem cell function and support tissue regeneration.
In one study, the effects of NMN on stem cell function both in vitro and in vivo were examined. The proliferating, migrating, and differentiating potential of stem cells increased after NMN administration. Also, they discovered that NMN supplementation enhanced stem cell performance in vivo, as shown by animals with increased tissue regeneration and wound repair. The scientists hypothesized that NMN would be useful as a medicinal drug for enhancing stem cell performance and encouraging tissue regeneration.¹¹
8. May Prevent age-related changes in gene expression
Age-related declines in NAD+ levels are common, and NAD+ is essential for controlling gene expression. Supplementing with NMN may maintain healthy gene expression and fend off age-related alterations by raising levels of NAD+ in the body.
Epigenetic alterations, which affect gene expression without affecting the DNA sequence itself, are crucial in the aging process and the development of age-related illnesses. According to some studies, using NMN supplements could assist in improving epigenetic control, which would result in healthier gene expression patterns.
Age-related changes in gene expression can be attributed to chronic inflammation. According to some studies, using NMN supplements may assist in lowering inflammation in the body, which may avoid changes in gene expression brought on by aging.
The effects of NMN supplementation on gene expression, mitochondrial function, and lifespan in mice were examined in one study. The research team discovered that NMN supplementation stopped age-related changes in gene expression, resulting in better mitochondrial function and a longer life span. The study authors hypothesized that NMN would be useful as a therapeutic drug for encouraging healthy aging and avoiding age-related alterations in gene expression.¹² ¹³
Side Effects of NMN
When taken according to recommended dosage guidelines, NMN supplementation is safe with no major side effects. As with any supplement, however, there is the possibility of some minor side effects. These may include:
Nausea
Diarrhea
Indigestion
Flushing/redness of the skin
Headaches or migraine
Insomnia
NMN supplements may also interact with certain medications, such as blood thinners. If you are taking any type of medication, you should consult your doctor before taking an NMN supplement.¹?
What to look for when buying NMN supplements:
To make sure that you get an NMN supplement that provides the quality and effectiveness you deserve, you need to follow a few buying guidelines. Here are seven key things to consider:
1. Ingredients
Obviously, nicotinamide mononucleotide should be the main ingredient in an NMN supplement. While there is only one form of NMN, some supplements may include other ingredients that are designed to work synergistically alongside NMN to boost its effectiveness. Here are five ingredients that are commonly added to NMN supplements:
Resveratrol: The chemical resveratrol is thought to boost the effects of NMN. It is derived from peanuts, red grapes, and other plants.
Polyphenols: Plant components known as polyphenols have antioxidant capabilities and may enhance general health and wellness. Other polyphenols like quercetin or catechins may also be present in some NMN supplements.
Vitamins and minerals: Certain NMN supplements may include extra vitamins and minerals, such as magnesium or vitamin D, that are thought to improve general health and wellness.
Nucleotides: Nicotinamide riboside (NR), another precursor to NAD+, is one of the additional nucleotides that some NMN supplements may contain.
2. Dosage
When purchasing an NMN supplement, it's important to carefully read the administration guidelines and search for the suggested dosage on the label. Clinical studies typically use daily dosages of 100-500mg, while some participants may get higher levels.
3. Delivery Method
NMN supplements come in a variety of forms, each of which has advantages and disadvantages. Here's an overview of the various delivery methods:
NMN Capsules: Many NMN supplements come in capsule form, which makes them convenient and easy to take. It is easier to regulate your daily intake because they normally contain a defined amount of NMN.
Pure NMN Powder: NMN supplements are available in a powder form that can be blended with water, juice, or other beverages. This provides a flexible and individualized approach to taking the supplement. On the other hand, powders could be more challenging to measure precisely, and their taste might not be to everyone's liking.
Sublingual: Sublingual NMN supplements are intended to be ingested under the tongue so that the NMN can pass through the mucous membranes and into the bloodstream. Although the flavor and texture of this distribution method may not be to everyone's tastes, it may be more efficient than other approaches.
Nasal sprays: Supplements containing NMN are available in nasal spray form. This is intended to be sprayed into the nostrils to allow for NMN absorption through the nasal membranes.
Transdermal patches: NMN supplements in the form of transdermal patches are intended to be applied to the skin in order for the NMN to pass through the skin and enter the bloodstream.
4. Testing/Transparency
I recommend dealing with a supplement company that employs a 3rd party laboratory to conduct testing for potency and purity on all of its supplements. This will give you confidence that you are getting exactly what is listed on the product label and that the product is free of any banned substances.
Make sure that the product label includes the individual dosages of each ingredient. Some labels bunch ingredients together as a proprietary blend, only giving the total dosage of all the ingredients. These should be avoided.
Check, too, that the product is manufactured in a Good Manufacturing Processes (GMP) certified facility.
5. Price
The price you pay for an NMN supplement is often a reflection of the quality of the product. Typically, NMN supplements that have undergone 3rd party testing for purity and potency will be slightly more expensive than those that aren't. The dosage of NMN used, and other ingredients may also affect the price. Brand reputation is another factor that may affect the price of the supplement.
6. Availability
It's important to think about availability when purchasing an NMN supplement. The following points should be taken into account:
Online vs. in-store: You may be able to buy NMN supplements both online and in-store. Online shopping may be more practical, but you should still check the reputation of the vendor and the quality of the goods.
Local accessibility: Find out whether your neighborhood health food or supplement stores provide NMN supplements. This can be an easy approach to go out and get the supplement right away without having to wait for delivery.
Delivery times: Before making an online purchase of NMN supplements, be sure to check the shipping schedules to make sure the product will arrive on time.
Foreign accessibility: If you buy NMN supplements from a foreign provider, be aware of any restrictions or rules that could affect how the product is shipped.
7. Reviews
By reading reviews from verified purchasers, you will gain insight into real-life experiences with the product. This will allow you to see whether the manufacturer's claimed benefits actually stack up. You can also find out about side effects that people experience and whether there are any potential delivery or other customer issues with the company.
NMN Supplement FAQs
What does AN NMN Supplement do?
NMN supplements are precursors to the coenzyme NAD+. That means they are involved in the body's production of the coenzyme. So, when you take an NMN supplement, you are able to increase the concentration of NAD+ in the body. Research has shown that taking an NMN supplement may have the following benefits:
Improved energy and metabolism
Enhanced cognitive function
Cardiovascular health benefits
DNA repair and protection
Support for healthy aging
Improved exercise performance
Does NMN really work?
In laboratory and animal investigations, NMN has produced encouraging results; however, additional studies are needed to establish its safety and efficacy in people. The scientific evidence is still minimal, and more thorough research is required to corroborate these results. That being said, the research that does exist suggests that supplementing with NMN, through its ability to increase NAD+ levels, is able to increase energy levels, boost brain functioning, enhance cardio health, help repair and protect DNA, and improve workout performance.
Increased levels of NAD+, brought on by NMN supplementation, may also help offset many of the biomarkers of aging.
Is NMN just vitamin B3?
No, NMN is not the same thing as vitamin B3. However, NMN is a derivative of vitamin B3, which is also known as niacin. NMN is a nucleotide that the body naturally produces. B3 is a water-soluble vitamin. They are both involved in energy production and DNA repair. Both compounds are also precursors of NAD+, but NMN is a more specific and important precursor. So, if you had to choose between supplementing with NMN and Vitamin B3 in order to boost NAD+ levels, NMN is the better option.
Is NMN banned?
NMN supplements can be purchased and sold legally in all countries, and they are not currently prohibited by any regulatory bodies. It is important to remember, though, that the FDA does not regulate NMN supplements, so brand quality and safety may be questionable.
Is it ok to take NMN daily?
Yes, it is ok to take NMN daily, provided that you stick to the recommended dosage.
Is NMN safe?
NMN appears to be safe, according to the most recent studies on animals and people. However, more research is needed to definitively determine the long-term safety of the supplement. Some short-term minor side effects that have shown up include nausea, diarrhea, indigestion, flushing/redness of the skin, headaches or migraine, and insomnia.
Summary
NMN supplements have become popular lately as a result of the growing investigation into longevity and anti-aging. It has been shown to have a number of potential benefits as a result of its ability to increase NAD+ levels in the body. The best NMN supplement on the market today, according to my research and experience, is Wonderfeel Younger NMN, which provides you with 450 mg of NMN, along with other ingredients such as resveratrol and vitamin D3. It also makes use of an advanced activation system to increase bioavailability.
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References
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., ... & Lavery, G. G. (2019). Nicotinamide riboside augments the age-associated decline in mitochondrial function and aerobic capacity in mice. Nature communications, 10(1), 1-14.
Yamamoto, T., Byun, J., Zhai, P., Ikeda, H., Oka, S., & Sadoshima, J. (2014). Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PloS one, 9(6), e98972.
Zhang, Q., Wang, S., Fleuriel, C., Leclercq, F., Shu, C., Liu, H., ... & Ji, Y. (2021). Nicotinamide mononucleotide rejuvenates post-ischaemic vascular regeneration by enhancing endothelial proliferation and preventing senescence. European heart journal, 42(2), 146-161.
Long, A. N., Owens, K., Schlappal, A. E., Kristian, T., & Fishman, P. S. (2015). Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia. Neurobiology of disease, 82, 492-505.
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Rep. 2020 Feb 11;30(6):1670-1681.e7. doi: 10.1016/j.celrep.2020.01.058. PMID: 32049001; PMCID: PMC7063679.
Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mazala, D. A., Mouchiroud, L., ... & Auwerx, J. (2016). NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine, 8(361), 361ra139.
Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., ... & Bohr, V. A. (2016). NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair. Cell metabolism, 24(4), 566-581.
Yoshida, S., Hongu, T., Suzuki, T., Nada, S., & Mannen, K. (2021). Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, improves stem cell function in vitro and in vivo. Aging cell, 20(1), e13301.
Gomes, A. P., Price, N. L., Ling, A. J., Moslehi, J. J., Montgomery, M. K., Rajman, L., ... & Sinclair, D. A. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624-1638.
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., ... & Sauve, A. A. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.
Mills, C. E., Tarrant, D. S., Zhu, Y., & Hruby, V. J. (2020). Evaluation of the safety and tolerability of nicotinamide mononucleotide in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific reports, 10(1), 1-10.
For centuries, humankind has been on a quest for the fountain of youth - a way to reverse the relentless effects of aging. Over the years, a number of supposed time-defying products have emerged onto the market. One supplement that has been receiving a lot of attention lately is nicotinamide mononucleotide, a.k.a. NMN anti-aging supplements.
NMN's ability to boost the body's levels of the coenzyme NAD+ may be able to bring about a whole host of health benefits. These include increasing energy output, enhancing brain function, and preventing age-related changes in gene expression.
To prepare for this article, I've gone deep into the NMN supplement market to find the nine best NMN supplements currently being sold. As well as providing personal reviews of each of these products, I'll also delve into the research-backed benefits of taking an NMN supplement and provide you with a comprehensive buyer's guide to help you sort out the best from the rest.
Wonderfeel
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS Sublingual Pick
Renue By Science
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS XR Pick
Nootropics Depot
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
**There may be affiliate links in this post where we might receive a small commission on purchases you make. We only recommend products we think you will find valuable.**
9 Best NMN Supplements:
[*]
Overall Best NMN Supplement: Wonderfeel Youngr NMN
[*]
Best Sublingual NMN Supplement: Renue By Science NMNs
[*]
Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
[*]
Best Powder NMN Supplement: Double Wood NMN Powder
[*]
Best Budget NMN Supplement: BulkSupplements NMN
[*]
Best Liposomal NMN Supplement: Renue By Science Lipo NMN
[*]
Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
[*]
Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
[*]
Best Liquid NMN Supplement: Quicksilver Scientific
1. Overall Best NMN Supplement: Wonderfeel Youngr NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Wonderfeel Youngr NMN, as the name suggests, is geared toward promoting longevity. As well as providing you with 900 mg of NMN per serving, you also get a range of other compounds that have been shown to work synergistically alongside NMN to enhance its effects. These include resveratrol, ergo, hydroxytyrosol, and vitamin D3.
The large dose of NMN that you get in this supplement has been specially formulated by a Harvard MD for enhanced bioavailability. So, as well as giving you more NMN than any other brand I came across, it also has greater absorbency so that more of the active ingredient gets into your body's cells.
There is no gluten, soy, dairy, or fish in this supplement. That means that it is vegan-friendly, It's also non-GMO, and does not contain any preservatives. A rice hull powder has been added to improve stabilization. I've recommended this NMN supplement to a few of my personal training clients, and none of them have had issues like stomach upset or bloating. I'm pretty sure this is due to the enhanced stabilization that comes from the rice hull powder.
Each container of Wonderfeel Youngr NMN contains 60 capsules. With a daily recommended dosage of two capsules, that's enough for a 30-day supply. At just under $90 for a one-time purchase, this is a pretty expensive supplement. However, you can sign up for a subscription, which knocks off $15.
Pros
[*]
+High NMN dosage
[*]
+Excellent absorbency
[*]
+Vegan friendly
[/list]
Cons
[*]
-Quite expensive
[/list]
Overall Best NMN Supplement
Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend...
2. Best Sublingual NMN Supplement: Renue By Science NMNs
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue by Science provides a range of pharmaceutical-grade NMN supplements in a number of different forms. This company is committed to delivering a high level of absorbency with its products. That is a big deal because many supplements have a very poor rate of absorbency in the body.
The sublingual NMN supplement that Renue offers provides excellent absorption. When I took it under my tongue, I felt the effects in my system a lot faster than when I took a capsule form with similar ingredients. That means that you get a lot more potency for a lower dosage.
Unlike many sublingual supplements, I didn't experience any nasty aftertaste with Renue By Science NMNs. In fact, it has a natural lemonade flavor which I enjoyed, and has an easy-to-absorb texture.
The product also includes natural additives to increase absorption. It's completely free of preservatives and artificial flavors and, as with all Renue by Science products, is 3rd party tested for purity and potency.
Each NMN tablet contains 125 mg of NMN, and you get 240 tablets in each container. The serving size is two tablets, providing you with a 3-month supply.
Renue by Science NMNs is well-priced and, as a bonus, provides free shipping on domestic US orders.
Pros
[*]
+Fast absorbency
[*]
+Pleasant lemonade taste
[*]
+250 mg NMN per serving
[/list]
Cons
[*]
-Does not offer a money-back guarantee
[/list]
Best Sublingual NMN Supplement
These tablets can be chewed or used sublingually (under the tongue). A percentage of the NMN is absorbed directly to the bloodstream and is available to cells...
3. Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Nootropics Depot NMN Tablets provide a slow release of the NMN into your system. This sustained release provides a longer-lasting effect. This may mean you don't have to take the supplement as often as a faster-release alternative.
Slow-release NMN supplements may also have fewer side effects, according to some research, as well as better absorption, utilization, and the ability to maintain more stable blood sugar levels.
You get 125 mg of NMN with each capsule of Nootropics NMN tablets. That is a relatively low dosage but may be compensated for by the increased absorbency. Each tablet has an enteric coating to further increase the bioavailability. This coating prevents the disintegration of the supplement in the stomach, allowing it to reach the small intestine fully intact.
Nootropics Depot offers this supplement in either a 30 or 60-count jar. The recommended daily dosage is one capsule.
Pros
[*]
+Slow-release form of NMN
[*]
+Increased absorbency
[*]
+Enteric coating to prevent disintegration in the stomach
[/list]
Cons
[*]
-Relatively low NMN dose
[/list]
Best Slow-Release NMN Supplement
The enteric coating on these tablets prevents disintegration of the NMN tablet in the stomach and instead delays tablet disintegration until the NMN tablet reaches the small intestines...
4. Best Powder NMN Supplement: Double Wood NMN Powder
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Double Wood NMN Powder is as pure and simple as it gets. Every serving provides you with 1 gram of NMN powder - and nothing else. With 30 grams in each container, you've got enough for a one-month supply.
This product is vegan friendly and is non-GMO, preservative, gluten, filler, and additive free. Even though the ingredient label gives the dosage as 1 gram, the website recommends breaking that up into several smaller dosages rather than taking it all at once. It is claimed that, due to the short half-life of NMN, taking 3-4 four dosages spaced a couple of hours apart, you will be better able to elevate NAD+ levels.
This powder does a decent job of mixing, but you may be left with a bit of residue if you're just mixing it with a spoon in your glass of water.
One thing I especially appreciate about Double Wood as a supplement manufacturer is that it is very transparent about its products. The company employs a 3rd party laboratory to carry out testing for purity and potency. You can even check the 3rd party testing details on the official website.
Pros
[*]
+3rd party tested
[*]
+1 gram NMN per serving
[*]
+Vegan friendly
[/list]
Cons
[*]
-Doesn't mix overly well
[*]
-No added ingredients
[/list]
Best Powder NMN Supplement
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound that is in small amounts in the human body as well as some foods. NMN is orally bioavailable...
5. Best Budget NMN Supplement: BulkSupplements NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
BulkSupplements have created a thriving business by supplying simple, no-frills health and fitness supplements with basic packaging at a budget price and with top quality. Their NMN supplement is a good example of that business model in action.
I recommend BulkSupplements products to my personal training clients more than any other brand. I do so because, after many years of using their products, I have absolute confidence in the purity and effectiveness of their supplements.
The powder in this NMN supplement mixes well to give you a smooth consistency when you drink it. The recommended serving size for BulkSupplements NMN is 250 mg. With each bag providing you with 10 grams, that gives you enough for 40 servings. You can also buy it in larger, bulk amounts, so long as they are not sold out.
Pros
[*]
+250 mg per serving
[*]
+Trusted brand
[*]
+Very cost-effective
[/list]
Cons
[*]
-No added ingredients
[/list]
Best Budget NMN Supplement
BulkSupplements NMN is a pure form of the nutrient nicotinamide mononucleotide (NMN). NMN is a precursor to NAD+, which is essential for cellular health and anti-aging...
6. Best Liposomal NMN Supplement: Renue By Science Lipo NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue By Science Lipo NMN is a powdered form of NMN that contains the liposomal form of the compound. The liposomal delivery system is a technique for supplying the body with nutrients in a way that improves their absorption and bioavailability.
Liposomes are tiny, spherical particles with a lipid bilayer, which resembles the composition of cell membranes. By joining with cell membranes, thanks to this structure, liposomes can transfer their contents directly into the cells.
There are 500 mg of NMN in every serving of Renue By Science Lipo NMN, with a serving being two capsules. Renue uses LIPO Caps™ with this product. These patented caps involve filling liposomes with nanoparticles that are subsequently freeze-dried to eliminate the aqueous phase. This ensures optimal stability and bioavailability while also guarding the ingredients against deterioration.
Pros
[*]
+500 mg NMN per serving
[*]
+Liposomal delivery system
[*]
+LIPO Caps™ for enhanced bioavailability
[*]
+Mixes well
[/list]
Cons
[*]
-No added ingredients
[/list]
Best Liposomal NMN Supplement
LIPO NMN features proprietary, powder-based liposomes that protect NMN from digestive enzymes & carry it into the bloodstream for targeted systemic delivery...
7. Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Peak Performance NMN + Resveratrol combines 150 mg of NMN with the same amount of resveratrol to supercharge the supplement's effectiveness. Both resveratrol and NMN have been demonstrated to enhance cellular regeneration and repair procedures that lessen the effects of aging. These compounds may combine to strengthen their anti-aging benefits when taken together.
Resveratrol has been demonstrated to have cardioprotective properties, while NMN may support improved blood vessel function and oxidative stress reduction. Mixing these substances may enhance cardiovascular health in general.
Resveratrol has also been shown in animal studies to enhance cognitive performance, while NMN has been found to assist brain function and repair procedures. Together, these compounds could enhance cognition in general and memory, concentration, and focus in particular.
Peak Performance NMN + Resveratrol is 3rd party tested for purity and potency. It is vegan and allergy free. It is also free of soy, milk, egg, shellfish, corn, wheat & peanuts. It contains no gluten or preservatives. The supplement is manufactured under GMP regulations and USA Standards.
The serving size for Peak Performance NMN + Resveratrol is one vegan capsule, and there are 30 capsules per container.
Pros
[*]
+NMN + Resveratrol
[*]
+Increased absorbency
[*]
+3rd party tested
[/list]
Cons
[*]
-The company is not NSF certified
[/list]
Best NMN + Resveratrol Supplement
Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs...
8. Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Prohealth Longevity NMN Pro provides you with 300 mg of NMN per two-capsule serving. According to the manufacturer, this is the only NMN supplement that has been clinically proven to boost NAD+ levels in humans. In a study, NAD+ levels were increased by 38% in 60 days - the equivalent of a 12-year reversal.
Prohealth has been selling top-quality supplements for 34 years, having established a reputation for quality, purity, and value. I have personally used their supplements for many years and have always been very pleased with the effectiveness of their supplements. The company has an A+ rating with the Better Business Bureau.
Every batch of Prohealth Longevity NMN Pro is 3rd party tested for potency and purity. All 3rd party lab certificates of analysis are publicly posted on the company website. The supplement is manufactured in an FDA-registered, GMP-certified facility in the USA.
Pros
[*]
+300 mg of NMN per serving
[*]
+3rd party tested
[*]
+Confirmed to be effective in a clinical study
[*]
+Vegan friendly
[/list]
Cons
[*]
-Reported to induce sleepiness by some reviewers
[/list]
Best Absorbability NMN Supplement
ProHealth Uthever NMN: The ONLY NMN CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed double blind placebo controlled clinical study...
9. Best Liquid NMN Supplement: Quicksilver Scientific
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Quicksilver Scientific is a liquid form of NMN supplement. Taking NMN in liquid form is believed to provide the greatest absorbency. They may also allow for more precise dosing than taking a powder or capsule form of the supplement. If you have issues swallowing capsules or tablets, liquid may be the best form for you.
Every dose of Quicksilver Scientific gives you 50 mg of NMN, blended with methylation cofactors and sirtuin activators to boost its effectiveness. It includes quercetin, TMG, riboflavin, and vitamin B12, which have been shown to work with NMN to make it more active.
Quicksilver scientific claims that its products utilize the world's most advanced phospholipid delivery system. That means that the core ingredients will get into your body's cells faster.
To be honest, the taste of Quicksilver Scientific is not great. But it doesn't have very much of an aftertaste, so the unpleasantness goes away pretty quickly.
Pros
[*]
+50 mn MNM in liquid form
[*]
+Improved absorbency
[*]
+Advanced phospholipid system
[/list]
Cons
[*]
-Taste is not the best
[/list]
Best Liquid NMN Supplement
NAD+ Platinum is a blend of NMN, methylation cofactors and sirtuin activators. It combines the action of 3 separate products (NAD Gold, Methyl Charge and The One)...
What is NMN?
NMN stands for nicotinamide mononucleotide. The NMN molecule plays a key role in the body's production of energy. NMN is a precursor to the coenzyme NAD+ or nicotinamide adenine dinucleotide. A precursor is a compound that is needed for the body to produce another compound. NAD+ is pivotal to a range of biological processes, including metabolism, gene expression, and DNA repair.
Our bodies naturally produce NMN. However, as we age, that production declines. Supplementing with an NMN supplement can increase those levels to promote higher production of NAD+ in the body.
Supplementing with NMN has been shown to actually be better than taking an NAD+ supplement. That is because NMN molecules are much smaller and are, therefore, better able to be absorbed and utilized by the body.
Benefits of NMN:
In recent years, there has been a lot of research into the benefits of both NMN and NAD+. Here are the eight key benefits of taking an NMN supplement.
1. Increases energy
As stated, NMN is a precursor of NAD+, a coenzyme that is essential for the synthesis of cellular energy. The process by which nutrients are transformed into ATP, the energy-producing molecule for cells, involves NAD+. Supplementing with NMN may help to enhance cellular energy generation and fight fatigue by raising NAD+ levels in the body.
NMN may also assist in enhancing muscle performance and reducing exhaustion during workouts. In one study, NMN supplementation in mice enhanced endurance and decreased fatigue during physical activity.
By accelerating the body's breakdown of fats and sugars, NMN may help boost metabolism. This increases calorie burn to produce more energy.¹ ²
2. Revitalizes blood vessels
Blood flow and blood pressure are significantly influenced by endothelial cells, which line the interior of our blood arteries. A body of clinical research suggests that NMN supplementation may assist in enhancing endothelial function, which will increase blood flow and lower the risk of cardiovascular disease.
According to some studies, NMN supplementation may help to reduce inflammation in the body. Chronic inflammation is a key risk factor for cardiovascular disease. NMN may improve overall cardiovascular health by decreasing inflammation and defending blood vessels from harm.
Nitric oxide is a chemical that is important for numerous physiological functions, including controlling blood flow and blood pressure. According to some research, using NMN supplements may help to boost nitric oxide levels.
One study used a mouse model of ischemia-reperfusion injury to look at how NMN affected the heart. The study's findings—which were supported by improved blood vessel function, higher blood flow, and decreased oxidative stress—show that NMN supplementation lessened the severity of the heart injury and improved blood vessel function. According to the researchers, NMN might be useful as a therapeutic drug to enhance blood vessel function and lower cardiovascular risk.³ ?
3. Improves Memory
As we age, our bodies produce less NMN. This may contribute to age-related cognitive decline, increasing memory loss. NMN supplementation has been shown to increase mitochondrial function inside the cell. Some researchers believe that this helps with cognitive functioning.
Higher levels of NAD+ result in reduced oxidative stress. This, too, has been associated with improved cognitive performance, including better memory.
In one study, NMN's impact on brain damage caused by global cerebral ischemia in mice was examined. The researchers discovered that NMN supplementation decreased brain damage and enhanced cognitive performance, as shown by improved memory in a test of fear conditioning. The researchers hypothesized that NMN could have potential as a therapeutic drug for enhancing cognitive performance and lessening the symptoms of brain damage.?
4. Boosts metabolism
NAD+ is essential in the synthesis and utilization of cellular energy. NMN supplementation may support a healthy metabolism and the production of energy since it raises the body's levels of NAD+.
Mitochondria are the organelles in cells that produce energy through cellular respiration. An increased mitochondrial function may result in enhanced energy production and metabolism when NMN supplementation is used.
Persistent inflammation contributes to a range of diseases, including metabolic dysfunction, Type 2 diabetes, and obesity. Research shows that reducing inflammation by taking an NMN supplement may boost metabolic health.
Supplementing NMN may also increase insulin sensitivity. This could result in increased energy production.? ?
5. May Increase fertility
By promoting healthy mitochondrial function and energy production, NMN supplementation might help to improve ovarian function. Women who are suffering from ovarian function decline brought on by aging may find this to be helpful.
Oocytes, also known as egg cells, are what sperm fertilize in the womb. Oocyte quality has been seen to be improved by increased NAD+ levels. The chances of a successful conception may, therefore, increase as a result of NMN supplementation, according to research.
By harming cells and DNA, oxidative stress can cause infertility. According to some research, using NMN supplements may help women have healthier fertility and less oxidative stress.
Although the majority of studies on NMN and fertility have focused on women, several studies have suggested that NMN supplementation may also have benefits for men. According to one study, NMN supplementation may increase sperm count in mice.?
6. Repairs DNA damage
Due to its involvement in the activity of enzymes that aid in the repair of damaged DNA, NAD+ is essential for DNA repair. The activities involved in DNA repair may be supported by NMN supplementation since it raises the body's levels of NAD+.
NMN supplementation may help in improving cellular energy generation by promoting healthy mitochondrial function, which is necessary for the energy-intensive DNA repair processes. Cells that are actively mending DNA damage might benefit from this.
Because oxidative stress can harm DNA, lowering it may aid in the processes that support DNA repair. According to some studies, taking NMN supplements may help the body lower oxidative stress levels, which may support DNA repair.
One study looked at how giving NMN to animals with muscular dystrophy affected DNA damage and repair mechanisms. The researchers discovered that NMN supplementation increased DNA repair mechanisms, resulting in reduced DNA damage and enhanced muscle performance. The researchers hypothesized that NMN supplementation might have therapeutic potential for enhancing DNA repair mechanisms and minimizing DNA damage.? ¹?
7. May improve stem cell health
NAD+ has a role to play in regulating stem cell function. NMN's ability to increase NAD+ levels means that it may help improve stem cell health. The mitochondria in cells, which are key to energy production, are also necessary for stem cell health. NMN supplementation, as we have already noted, helps to improve mitochondrial activity.
There is also some evidence to imply that NMN supplementation may help to reduce cellular senescence, or aging and death, in stem cells. Other research suggests that NMN supplementation may help to improve stem cell function and support tissue regeneration.
In one study, the effects of NMN on stem cell function both in vitro and in vivo were examined. The proliferating, migrating, and differentiating potential of stem cells increased after NMN administration. Also, they discovered that NMN supplementation enhanced stem cell performance in vivo, as shown by animals with increased tissue regeneration and wound repair. The scientists hypothesized that NMN would be useful as a medicinal drug for enhancing stem cell performance and encouraging tissue regeneration.¹¹
8. May Prevent age-related changes in gene expression
Age-related declines in NAD+ levels are common, and NAD+ is essential for controlling gene expression. Supplementing with NMN may maintain healthy gene expression and fend off age-related alterations by raising levels of NAD+ in the body.
Epigenetic alterations, which affect gene expression without affecting the DNA sequence itself, are crucial in the aging process and the development of age-related illnesses. According to some studies, using NMN supplements could assist in improving epigenetic control, which would result in healthier gene expression patterns.
Age-related changes in gene expression can be attributed to chronic inflammation. According to some studies, using NMN supplements may assist in lowering inflammation in the body, which may avoid changes in gene expression brought on by aging.
The effects of NMN supplementation on gene expression, mitochondrial function, and lifespan in mice were examined in one study. The research team discovered that NMN supplementation stopped age-related changes in gene expression, resulting in better mitochondrial function and a longer life span. The study authors hypothesized that NMN would be useful as a therapeutic drug for encouraging healthy aging and avoiding age-related alterations in gene expression.¹² ¹³
Side Effects of NMN
When taken according to recommended dosage guidelines, NMN supplementation is safe with no major side effects. As with any supplement, however, there is the possibility of some minor side effects. These may include:
What to look for when buying NMN supplements:
To make sure that you get an NMN supplement that provides the quality and effectiveness you deserve, you need to follow a few buying guidelines. Here are seven key things to consider:
1. Ingredients
Obviously, nicotinamide mononucleotide should be the main ingredient in an NMN supplement. While there is only one form of NMN, some supplements may include other ingredients that are designed to work synergistically alongside NMN to boost its effectiveness. Here are five ingredients that are commonly added to NMN supplements:
When purchasing an NMN supplement, it's important to carefully read the administration guidelines and search for the suggested dosage on the label. Clinical studies typically use daily dosages of 100-500mg, while some participants may get higher levels.
3. Delivery Method
NMN supplements come in a variety of forms, each of which has advantages and disadvantages. Here's an overview of the various delivery methods:
NMN's ability to boost the body's levels of the coenzyme NAD+ may be able to bring about a whole host of health benefits. These include increasing energy output, enhancing brain function, and preventing age-related changes in gene expression.
To prepare for this article, I've gone deep into the NMN supplement market to find the nine best NMN supplements currently being sold. As well as providing personal reviews of each of these products, I'll also delve into the research-backed benefits of taking an NMN supplement and provide you with a comprehensive buyer's guide to help you sort out the best from the rest.
Wonderfeel
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS Sublingual Pick
Renue By Science
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS XR Pick
Nootropics Depot
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
**There may be affiliate links in this post where we might receive a small commission on purchases you make. We only recommend products we think you will find valuable.**
9 Best NMN Supplements:
Overall Best NMN Supplement: Wonderfeel Youngr NMN
Best Sublingual NMN Supplement: Renue By Science NMNs
Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
Best Powder NMN Supplement: Double Wood NMN Powder
Best Budget NMN Supplement: BulkSupplements NMN
Best Liposomal NMN Supplement: Renue By Science Lipo NMN
Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
Best Liquid NMN Supplement: Quicksilver Scientific
1. Overall Best NMN Supplement: Wonderfeel Youngr NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Wonderfeel Youngr NMN, as the name suggests, is geared toward promoting longevity. As well as providing you with 900 mg of NMN per serving, you also get a range of other compounds that have been shown to work synergistically alongside NMN to enhance its effects. These include resveratrol, ergo, hydroxytyrosol, and vitamin D3.
The large dose of NMN that you get in this supplement has been specially formulated by a Harvard MD for enhanced bioavailability. So, as well as giving you more NMN than any other brand I came across, it also has greater absorbency so that more of the active ingredient gets into your body's cells.
There is no gluten, soy, dairy, or fish in this supplement. That means that it is vegan-friendly, It's also non-GMO, and does not contain any preservatives. A rice hull powder has been added to improve stabilization. I've recommended this NMN supplement to a few of my personal training clients, and none of them have had issues like stomach upset or bloating. I'm pretty sure this is due to the enhanced stabilization that comes from the rice hull powder.
Each container of Wonderfeel Youngr NMN contains 60 capsules. With a daily recommended dosage of two capsules, that's enough for a 30-day supply. At just under $90 for a one-time purchase, this is a pretty expensive supplement. However, you can sign up for a subscription, which knocks off $15.
Pros
+High NMN dosage
+Excellent absorbency
+Vegan friendly
Cons
-Quite expensive
Overall Best NMN Supplement
Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend...
2. Best Sublingual NMN Supplement: Renue By Science NMNs
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue by Science provides a range of pharmaceutical-grade NMN supplements in a number of different forms. This company is committed to delivering a high level of absorbency with its products. That is a big deal because many supplements have a very poor rate of absorbency in the body.
The sublingual NMN supplement that Renue offers provides excellent absorption. When I took it under my tongue, I felt the effects in my system a lot faster than when I took a capsule form with similar ingredients. That means that you get a lot more potency for a lower dosage.
Unlike many sublingual supplements, I didn't experience any nasty aftertaste with Renue By Science NMNs. In fact, it has a natural lemonade flavor which I enjoyed, and has an easy-to-absorb texture.
The product also includes natural additives to increase absorption. It's completely free of preservatives and artificial flavors and, as with all Renue by Science products, is 3rd party tested for purity and potency.
Each NMN tablet contains 125 mg of NMN, and you get 240 tablets in each container. The serving size is two tablets, providing you with a 3-month supply.
Renue by Science NMNs is well-priced and, as a bonus, provides free shipping on domestic US orders.
Pros
+Fast absorbency
+Pleasant lemonade taste
+250 mg NMN per serving
Cons
-Does not offer a money-back guarantee
Best Sublingual NMN Supplement
These tablets can be chewed or used sublingually (under the tongue). A percentage of the NMN is absorbed directly to the bloodstream and is available to cells...
3. Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Nootropics Depot NMN Tablets provide a slow release of the NMN into your system. This sustained release provides a longer-lasting effect. This may mean you don't have to take the supplement as often as a faster-release alternative.
Slow-release NMN supplements may also have fewer side effects, according to some research, as well as better absorption, utilization, and the ability to maintain more stable blood sugar levels.
You get 125 mg of NMN with each capsule of Nootropics NMN tablets. That is a relatively low dosage but may be compensated for by the increased absorbency. Each tablet has an enteric coating to further increase the bioavailability. This coating prevents the disintegration of the supplement in the stomach, allowing it to reach the small intestine fully intact.
Nootropics Depot offers this supplement in either a 30 or 60-count jar. The recommended daily dosage is one capsule.
Pros
+Slow-release form of NMN
+Increased absorbency
+Enteric coating to prevent disintegration in the stomach
Cons
-Relatively low NMN dose
Best Slow-Release NMN Supplement
The enteric coating on these tablets prevents disintegration of the NMN tablet in the stomach and instead delays tablet disintegration until the NMN tablet reaches the small intestines...
4. Best Powder NMN Supplement: Double Wood NMN Powder
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Double Wood NMN Powder is as pure and simple as it gets. Every serving provides you with 1 gram of NMN powder - and nothing else. With 30 grams in each container, you've got enough for a one-month supply.
This product is vegan friendly and is non-GMO, preservative, gluten, filler, and additive free. Even though the ingredient label gives the dosage as 1 gram, the website recommends breaking that up into several smaller dosages rather than taking it all at once. It is claimed that, due to the short half-life of NMN, taking 3-4 four dosages spaced a couple of hours apart, you will be better able to elevate NAD+ levels.
This powder does a decent job of mixing, but you may be left with a bit of residue if you're just mixing it with a spoon in your glass of water.
One thing I especially appreciate about Double Wood as a supplement manufacturer is that it is very transparent about its products. The company employs a 3rd party laboratory to carry out testing for purity and potency. You can even check the 3rd party testing details on the official website.
Pros
+3rd party tested
+1 gram NMN per serving
+Vegan friendly
Cons
-Doesn't mix overly well
-No added ingredients
Best Powder NMN Supplement
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound that is in small amounts in the human body as well as some foods. NMN is orally bioavailable...
5. Best Budget NMN Supplement: BulkSupplements NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
BulkSupplements have created a thriving business by supplying simple, no-frills health and fitness supplements with basic packaging at a budget price and with top quality. Their NMN supplement is a good example of that business model in action.
I recommend BulkSupplements products to my personal training clients more than any other brand. I do so because, after many years of using their products, I have absolute confidence in the purity and effectiveness of their supplements.
The powder in this NMN supplement mixes well to give you a smooth consistency when you drink it. The recommended serving size for BulkSupplements NMN is 250 mg. With each bag providing you with 10 grams, that gives you enough for 40 servings. You can also buy it in larger, bulk amounts, so long as they are not sold out.
Pros
+250 mg per serving
+Trusted brand
+Very cost-effective
Cons
-No added ingredients
Best Budget NMN Supplement
BulkSupplements NMN is a pure form of the nutrient nicotinamide mononucleotide (NMN). NMN is a precursor to NAD+, which is essential for cellular health and anti-aging...
6. Best Liposomal NMN Supplement: Renue By Science Lipo NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue By Science Lipo NMN is a powdered form of NMN that contains the liposomal form of the compound. The liposomal delivery system is a technique for supplying the body with nutrients in a way that improves their absorption and bioavailability.
Liposomes are tiny, spherical particles with a lipid bilayer, which resembles the composition of cell membranes. By joining with cell membranes, thanks to this structure, liposomes can transfer their contents directly into the cells.
There are 500 mg of NMN in every serving of Renue By Science Lipo NMN, with a serving being two capsules. Renue uses LIPO Caps™ with this product. These patented caps involve filling liposomes with nanoparticles that are subsequently freeze-dried to eliminate the aqueous phase. This ensures optimal stability and bioavailability while also guarding the ingredients against deterioration.
Pros
+500 mg NMN per serving
+Liposomal delivery system
+LIPO Caps™ for enhanced bioavailability
+Mixes well
Cons
-No added ingredients
Best Liposomal NMN Supplement
LIPO NMN features proprietary, powder-based liposomes that protect NMN from digestive enzymes & carry it into the bloodstream for targeted systemic delivery...
7. Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Peak Performance NMN + Resveratrol combines 150 mg of NMN with the same amount of resveratrol to supercharge the supplement's effectiveness. Both resveratrol and NMN have been demonstrated to enhance cellular regeneration and repair procedures that lessen the effects of aging. These compounds may combine to strengthen their anti-aging benefits when taken together.
Resveratrol has been demonstrated to have cardioprotective properties, while NMN may support improved blood vessel function and oxidative stress reduction. Mixing these substances may enhance cardiovascular health in general.
Resveratrol has also been shown in animal studies to enhance cognitive performance, while NMN has been found to assist brain function and repair procedures. Together, these compounds could enhance cognition in general and memory, concentration, and focus in particular.
Peak Performance NMN + Resveratrol is 3rd party tested for purity and potency. It is vegan and allergy free. It is also free of soy, milk, egg, shellfish, corn, wheat & peanuts. It contains no gluten or preservatives. The supplement is manufactured under GMP regulations and USA Standards.
The serving size for Peak Performance NMN + Resveratrol is one vegan capsule, and there are 30 capsules per container.
Pros
+NMN + Resveratrol
+Increased absorbency
+3rd party tested
Cons
-The company is not NSF certified
Best NMN + Resveratrol Supplement
Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs...
8. Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Prohealth Longevity NMN Pro provides you with 300 mg of NMN per two-capsule serving. According to the manufacturer, this is the only NMN supplement that has been clinically proven to boost NAD+ levels in humans. In a study, NAD+ levels were increased by 38% in 60 days - the equivalent of a 12-year reversal.
Prohealth has been selling top-quality supplements for 34 years, having established a reputation for quality, purity, and value. I have personally used their supplements for many years and have always been very pleased with the effectiveness of their supplements. The company has an A+ rating with the Better Business Bureau.
Every batch of Prohealth Longevity NMN Pro is 3rd party tested for potency and purity. All 3rd party lab certificates of analysis are publicly posted on the company website. The supplement is manufactured in an FDA-registered, GMP-certified facility in the USA.
Pros
+300 mg of NMN per serving
+3rd party tested
+Confirmed to be effective in a clinical study
+Vegan friendly
Cons
-Reported to induce sleepiness by some reviewers
Best Absorbability NMN Supplement
ProHealth Uthever NMN: The ONLY NMN CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed double blind placebo controlled clinical study...
9. Best Liquid NMN Supplement: Quicksilver Scientific
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Quicksilver Scientific is a liquid form of NMN supplement. Taking NMN in liquid form is believed to provide the greatest absorbency. They may also allow for more precise dosing than taking a powder or capsule form of the supplement. If you have issues swallowing capsules or tablets, liquid may be the best form for you.
Every dose of Quicksilver Scientific gives you 50 mg of NMN, blended with methylation cofactors and sirtuin activators to boost its effectiveness. It includes quercetin, TMG, riboflavin, and vitamin B12, which have been shown to work with NMN to make it more active.
Quicksilver scientific claims that its products utilize the world's most advanced phospholipid delivery system. That means that the core ingredients will get into your body's cells faster.
To be honest, the taste of Quicksilver Scientific is not great. But it doesn't have very much of an aftertaste, so the unpleasantness goes away pretty quickly.
Pros
+50 mn MNM in liquid form
+Improved absorbency
+Advanced phospholipid system
Cons
-Taste is not the best
Best Liquid NMN Supplement
NAD+ Platinum is a blend of NMN, methylation cofactors and sirtuin activators. It combines the action of 3 separate products (NAD Gold, Methyl Charge and The One)...
What is NMN?
NMN stands for nicotinamide mononucleotide. The NMN molecule plays a key role in the body's production of energy. NMN is a precursor to the coenzyme NAD+ or nicotinamide adenine dinucleotide. A precursor is a compound that is needed for the body to produce another compound. NAD+ is pivotal to a range of biological processes, including metabolism, gene expression, and DNA repair.
Our bodies naturally produce NMN. However, as we age, that production declines. Supplementing with an NMN supplement can increase those levels to promote higher production of NAD+ in the body.
Supplementing with NMN has been shown to actually be better than taking an NAD+ supplement. That is because NMN molecules are much smaller and are, therefore, better able to be absorbed and utilized by the body.
Benefits of NMN:
In recent years, there has been a lot of research into the benefits of both NMN and NAD+. Here are the eight key benefits of taking an NMN supplement.
1. Increases energy
As stated, NMN is a precursor of NAD+, a coenzyme that is essential for the synthesis of cellular energy. The process by which nutrients are transformed into ATP, the energy-producing molecule for cells, involves NAD+. Supplementing with NMN may help to enhance cellular energy generation and fight fatigue by raising NAD+ levels in the body.
NMN may also assist in enhancing muscle performance and reducing exhaustion during workouts. In one study, NMN supplementation in mice enhanced endurance and decreased fatigue during physical activity.
By accelerating the body's breakdown of fats and sugars, NMN may help boost metabolism. This increases calorie burn to produce more energy.¹ ²
2. Revitalizes blood vessels
Blood flow and blood pressure are significantly influenced by endothelial cells, which line the interior of our blood arteries. A body of clinical research suggests that NMN supplementation may assist in enhancing endothelial function, which will increase blood flow and lower the risk of cardiovascular disease.
According to some studies, NMN supplementation may help to reduce inflammation in the body. Chronic inflammation is a key risk factor for cardiovascular disease. NMN may improve overall cardiovascular health by decreasing inflammation and defending blood vessels from harm.
Nitric oxide is a chemical that is important for numerous physiological functions, including controlling blood flow and blood pressure. According to some research, using NMN supplements may help to boost nitric oxide levels.
One study used a mouse model of ischemia-reperfusion injury to look at how NMN affected the heart. The study's findings—which were supported by improved blood vessel function, higher blood flow, and decreased oxidative stress—show that NMN supplementation lessened the severity of the heart injury and improved blood vessel function. According to the researchers, NMN might be useful as a therapeutic drug to enhance blood vessel function and lower cardiovascular risk.³ ?
3. Improves Memory
As we age, our bodies produce less NMN. This may contribute to age-related cognitive decline, increasing memory loss. NMN supplementation has been shown to increase mitochondrial function inside the cell. Some researchers believe that this helps with cognitive functioning.
Higher levels of NAD+ result in reduced oxidative stress. This, too, has been associated with improved cognitive performance, including better memory.
In one study, NMN's impact on brain damage caused by global cerebral ischemia in mice was examined. The researchers discovered that NMN supplementation decreased brain damage and enhanced cognitive performance, as shown by improved memory in a test of fear conditioning. The researchers hypothesized that NMN could have potential as a therapeutic drug for enhancing cognitive performance and lessening the symptoms of brain damage.?
4. Boosts metabolism
NAD+ is essential in the synthesis and utilization of cellular energy. NMN supplementation may support a healthy metabolism and the production of energy since it raises the body's levels of NAD+.
Mitochondria are the organelles in cells that produce energy through cellular respiration. An increased mitochondrial function may result in enhanced energy production and metabolism when NMN supplementation is used.
Persistent inflammation contributes to a range of diseases, including metabolic dysfunction, Type 2 diabetes, and obesity. Research shows that reducing inflammation by taking an NMN supplement may boost metabolic health.
Supplementing NMN may also increase insulin sensitivity. This could result in increased energy production.? ?
5. May Increase fertility
By promoting healthy mitochondrial function and energy production, NMN supplementation might help to improve ovarian function. Women who are suffering from ovarian function decline brought on by aging may find this to be helpful.
Oocytes, also known as egg cells, are what sperm fertilize in the womb. Oocyte quality has been seen to be improved by increased NAD+ levels. The chances of a successful conception may, therefore, increase as a result of NMN supplementation, according to research.
By harming cells and DNA, oxidative stress can cause infertility. According to some research, using NMN supplements may help women have healthier fertility and less oxidative stress.
Although the majority of studies on NMN and fertility have focused on women, several studies have suggested that NMN supplementation may also have benefits for men. According to one study, NMN supplementation may increase sperm count in mice.?
6. Repairs DNA damage
Due to its involvement in the activity of enzymes that aid in the repair of damaged DNA, NAD+ is essential for DNA repair. The activities involved in DNA repair may be supported by NMN supplementation since it raises the body's levels of NAD+.
NMN supplementation may help in improving cellular energy generation by promoting healthy mitochondrial function, which is necessary for the energy-intensive DNA repair processes. Cells that are actively mending DNA damage might benefit from this.
Because oxidative stress can harm DNA, lowering it may aid in the processes that support DNA repair. According to some studies, taking NMN supplements may help the body lower oxidative stress levels, which may support DNA repair.
One study looked at how giving NMN to animals with muscular dystrophy affected DNA damage and repair mechanisms. The researchers discovered that NMN supplementation increased DNA repair mechanisms, resulting in reduced DNA damage and enhanced muscle performance. The researchers hypothesized that NMN supplementation might have therapeutic potential for enhancing DNA repair mechanisms and minimizing DNA damage.? ¹?
7. May improve stem cell health
NAD+ has a role to play in regulating stem cell function. NMN's ability to increase NAD+ levels means that it may help improve stem cell health. The mitochondria in cells, which are key to energy production, are also necessary for stem cell health. NMN supplementation, as we have already noted, helps to improve mitochondrial activity.
There is also some evidence to imply that NMN supplementation may help to reduce cellular senescence, or aging and death, in stem cells. Other research suggests that NMN supplementation may help to improve stem cell function and support tissue regeneration.
In one study, the effects of NMN on stem cell function both in vitro and in vivo were examined. The proliferating, migrating, and differentiating potential of stem cells increased after NMN administration. Also, they discovered that NMN supplementation enhanced stem cell performance in vivo, as shown by animals with increased tissue regeneration and wound repair. The scientists hypothesized that NMN would be useful as a medicinal drug for enhancing stem cell performance and encouraging tissue regeneration.¹¹
8. May Prevent age-related changes in gene expression
Age-related declines in NAD+ levels are common, and NAD+ is essential for controlling gene expression. Supplementing with NMN may maintain healthy gene expression and fend off age-related alterations by raising levels of NAD+ in the body.
Epigenetic alterations, which affect gene expression without affecting the DNA sequence itself, are crucial in the aging process and the development of age-related illnesses. According to some studies, using NMN supplements could assist in improving epigenetic control, which would result in healthier gene expression patterns.
Age-related changes in gene expression can be attributed to chronic inflammation. According to some studies, using NMN supplements may assist in lowering inflammation in the body, which may avoid changes in gene expression brought on by aging.
The effects of NMN supplementation on gene expression, mitochondrial function, and lifespan in mice were examined in one study. The research team discovered that NMN supplementation stopped age-related changes in gene expression, resulting in better mitochondrial function and a longer life span. The study authors hypothesized that NMN would be useful as a therapeutic drug for encouraging healthy aging and avoiding age-related alterations in gene expression.¹² ¹³
Side Effects of NMN
When taken according to recommended dosage guidelines, NMN supplementation is safe with no major side effects. As with any supplement, however, there is the possibility of some minor side effects. These may include:
Nausea
Diarrhea
Indigestion
Flushing/redness of the skin
Headaches or migraine
Insomnia
NMN supplements may also interact with certain medications, such as blood thinners. If you are taking any type of medication, you should consult your doctor before taking an NMN supplement.¹?
What to look for when buying NMN supplements:
To make sure that you get an NMN supplement that provides the quality and effectiveness you deserve, you need to follow a few buying guidelines. Here are seven key things to consider:
1. Ingredients
Obviously, nicotinamide mononucleotide should be the main ingredient in an NMN supplement. While there is only one form of NMN, some supplements may include other ingredients that are designed to work synergistically alongside NMN to boost its effectiveness. Here are five ingredients that are commonly added to NMN supplements:
Resveratrol: The chemical resveratrol is thought to boost the effects of NMN. It is derived from peanuts, red grapes, and other plants.
Polyphenols: Plant components known as polyphenols have antioxidant capabilities and may enhance general health and wellness. Other polyphenols like quercetin or catechins may also be present in some NMN supplements.
Vitamins and minerals: Certain NMN supplements may include extra vitamins and minerals, such as magnesium or vitamin D, that are thought to improve general health and wellness.
Nucleotides: Nicotinamide riboside (NR), another precursor to NAD+, is one of the additional nucleotides that some NMN supplements may contain.
2. Dosage
When purchasing an NMN supplement, it's important to carefully read the administration guidelines and search for the suggested dosage on the label. Clinical studies typically use daily dosages of 100-500mg, while some participants may get higher levels.
3. Delivery Method
NMN supplements come in a variety of forms, each of which has advantages and disadvantages. Here's an overview of the various delivery methods:
NMN Capsules: Many NMN supplements come in capsule form, which makes them convenient and easy to take. It is easier to regulate your daily intake because they normally contain a defined amount of NMN.
Pure NMN Powder: NMN supplements are available in a powder form that can be blended with water, juice, or other beverages. This provides a flexible and individualized approach to taking the supplement. On the other hand, powders could be more challenging to measure precisely, and their taste might not be to everyone's liking.
Sublingual: Sublingual NMN supplements are intended to be ingested under the tongue so that the NMN can pass through the mucous membranes and into the bloodstream. Although the flavor and texture of this distribution method may not be to everyone's tastes, it may be more efficient than other approaches.
Nasal sprays: Supplements containing NMN are available in nasal spray form. This is intended to be sprayed into the nostrils to allow for NMN absorption through the nasal membranes.
Transdermal patches: NMN supplements in the form of transdermal patches are intended to be applied to the skin in order for the NMN to pass through the skin and enter the bloodstream.
4. Testing/Transparency
I recommend dealing with a supplement company that employs a 3rd party laboratory to conduct testing for potency and purity on all of its supplements. This will give you confidence that you are getting exactly what is listed on the product label and that the product is free of any banned substances.
Make sure that the product label includes the individual dosages of each ingredient. Some labels bunch ingredients together as a proprietary blend, only giving the total dosage of all the ingredients. These should be avoided.
Check, too, that the product is manufactured in a Good Manufacturing Processes (GMP) certified facility.
5. Price
The price you pay for an NMN supplement is often a reflection of the quality of the product. Typically, NMN supplements that have undergone 3rd party testing for purity and potency will be slightly more expensive than those that aren't. The dosage of NMN used, and other ingredients may also affect the price. Brand reputation is another factor that may affect the price of the supplement.
6. Availability
It's important to think about availability when purchasing an NMN supplement. The following points should be taken into account:
Online vs. in-store: You may be able to buy NMN supplements both online and in-store. Online shopping may be more practical, but you should still check the reputation of the vendor and the quality of the goods.
Local accessibility: Find out whether your neighborhood health food or supplement stores provide NMN supplements. This can be an easy approach to go out and get the supplement right away without having to wait for delivery.
Delivery times: Before making an online purchase of NMN supplements, be sure to check the shipping schedules to make sure the product will arrive on time.
Foreign accessibility: If you buy NMN supplements from a foreign provider, be aware of any restrictions or rules that could affect how the product is shipped.
7. Reviews
By reading reviews from verified purchasers, you will gain insight into real-life experiences with the product. This will allow you to see whether the manufacturer's claimed benefits actually stack up. You can also find out about side effects that people experience and whether there are any potential delivery or other customer issues with the company.
NMN Supplement FAQs
What does AN NMN Supplement do?
NMN supplements are precursors to the coenzyme NAD+. That means they are involved in the body's production of the coenzyme. So, when you take an NMN supplement, you are able to increase the concentration of NAD+ in the body. Research has shown that taking an NMN supplement may have the following benefits:
Improved energy and metabolism
Enhanced cognitive function
Cardiovascular health benefits
DNA repair and protection
Support for healthy aging
Improved exercise performance
Does NMN really work?
In laboratory and animal investigations, NMN has produced encouraging results; however, additional studies are needed to establish its safety and efficacy in people. The scientific evidence is still minimal, and more thorough research is required to corroborate these results. That being said, the research that does exist suggests that supplementing with NMN, through its ability to increase NAD+ levels, is able to increase energy levels, boost brain functioning, enhance cardio health, help repair and protect DNA, and improve workout performance.
Increased levels of NAD+, brought on by NMN supplementation, may also help offset many of the biomarkers of aging.
Is NMN just vitamin B3?
No, NMN is not the same thing as vitamin B3. However, NMN is a derivative of vitamin B3, which is also known as niacin. NMN is a nucleotide that the body naturally produces. B3 is a water-soluble vitamin. They are both involved in energy production and DNA repair. Both compounds are also precursors of NAD+, but NMN is a more specific and important precursor. So, if you had to choose between supplementing with NMN and Vitamin B3 in order to boost NAD+ levels, NMN is the better option.
Is NMN banned?
NMN supplements can be purchased and sold legally in all countries, and they are not currently prohibited by any regulatory bodies. It is important to remember, though, that the FDA does not regulate NMN supplements, so brand quality and safety may be questionable.
Is it ok to take NMN daily?
Yes, it is ok to take NMN daily, provided that you stick to the recommended dosage.
Is NMN safe?
NMN appears to be safe, according to the most recent studies on animals and people. However, more research is needed to definitively determine the long-term safety of the supplement. Some short-term minor side effects that have shown up include nausea, diarrhea, indigestion, flushing/redness of the skin, headaches or migraine, and insomnia.
Summary
NMN supplements have become popular lately as a result of the growing investigation into longevity and anti-aging. It has been shown to have a number of potential benefits as a result of its ability to increase NAD+ levels in the body. The best NMN supplement on the market today, according to my research and experience, is Wonderfeel Younger NMN, which provides you with 450 mg of NMN, along with other ingredients such as resveratrol and vitamin D3. It also makes use of an advanced activation system to increase bioavailability.
More Best Supplement Resources
References
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., ... & Lavery, G. G. (2019). Nicotinamide riboside augments the age-associated decline in mitochondrial function and aerobic capacity in mice. Nature communications, 10(1), 1-14.
Yamamoto, T., Byun, J., Zhai, P., Ikeda, H., Oka, S., & Sadoshima, J. (2014). Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PloS one, 9(6), e98972.
Zhang, Q., Wang, S., Fleuriel, C., Leclercq, F., Shu, C., Liu, H., ... & Ji, Y. (2021). Nicotinamide mononucleotide rejuvenates post-ischaemic vascular regeneration by enhancing endothelial proliferation and preventing senescence. European heart journal, 42(2), 146-161.
Long, A. N., Owens, K., Schlappal, A. E., Kristian, T., & Fishman, P. S. (2015). Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia. Neurobiology of disease, 82, 492-505.
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Rep. 2020 Feb 11;30(6):1670-1681.e7. doi: 10.1016/j.celrep.2020.01.058. PMID: 32049001; PMCID: PMC7063679.
Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mazala, D. A., Mouchiroud, L., ... & Auwerx, J. (2016). NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine, 8(361), 361ra139.
Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., ... & Bohr, V. A. (2016). NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair. Cell metabolism, 24(4), 566-581.
Yoshida, S., Hongu, T., Suzuki, T., Nada, S., & Mannen, K. (2021). Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, improves stem cell function in vitro and in vivo. Aging cell, 20(1), e13301.
Gomes, A. P., Price, N. L., Ling, A. J., Moslehi, J. J., Montgomery, M. K., Rajman, L., ... & Sinclair, D. A. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624-1638.
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., ... & Sauve, A. A. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.
Mills, C. E., Tarrant, D. S., Zhu, Y., & Hruby, V. J. (2020). Evaluation of the safety and tolerability of nicotinamide mononucleotide in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific reports, 10(1), 1-10.
For centuries, humankind has been on a quest for the fountain of youth - a way to reverse the relentless effects of aging. Over the years, a number of supposed time-defying products have emerged onto the market. One supplement that has been receiving a lot of attention lately is nicotinamide mononucleotide, a.k.a. NMN anti-aging supplements.
NMN's ability to boost the body's levels of the coenzyme NAD+ may be able to bring about a whole host of health benefits. These include increasing energy output, enhancing brain function, and preventing age-related changes in gene expression.
To prepare for this article, I've gone deep into the NMN supplement market to find the nine best NMN supplements currently being sold. As well as providing personal reviews of each of these products, I'll also delve into the research-backed benefits of taking an NMN supplement and provide you with a comprehensive buyer's guide to help you sort out the best from the rest.
Wonderfeel
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS Sublingual Pick
Renue By Science
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
SFS XR Pick
Nootropics Depot
Ingredients
5.0
Efficacy
5.0
Overall Score
5.0
**There may be affiliate links in this post where we might receive a small commission on purchases you make. We only recommend products we think you will find valuable.**
9 Best NMN Supplements:
[*]
Overall Best NMN Supplement: Wonderfeel Youngr NMN
[*]
Best Sublingual NMN Supplement: Renue By Science NMNs
[*]
Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
[*]
Best Powder NMN Supplement: Double Wood NMN Powder
[*]
Best Budget NMN Supplement: BulkSupplements NMN
[*]
Best Liposomal NMN Supplement: Renue By Science Lipo NMN
[*]
Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
[*]
Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
[*]
Best Liquid NMN Supplement: Quicksilver Scientific
1. Overall Best NMN Supplement: Wonderfeel Youngr NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Wonderfeel Youngr NMN, as the name suggests, is geared toward promoting longevity. As well as providing you with 900 mg of NMN per serving, you also get a range of other compounds that have been shown to work synergistically alongside NMN to enhance its effects. These include resveratrol, ergo, hydroxytyrosol, and vitamin D3.
The large dose of NMN that you get in this supplement has been specially formulated by a Harvard MD for enhanced bioavailability. So, as well as giving you more NMN than any other brand I came across, it also has greater absorbency so that more of the active ingredient gets into your body's cells.
There is no gluten, soy, dairy, or fish in this supplement. That means that it is vegan-friendly, It's also non-GMO, and does not contain any preservatives. A rice hull powder has been added to improve stabilization. I've recommended this NMN supplement to a few of my personal training clients, and none of them have had issues like stomach upset or bloating. I'm pretty sure this is due to the enhanced stabilization that comes from the rice hull powder.
Each container of Wonderfeel Youngr NMN contains 60 capsules. With a daily recommended dosage of two capsules, that's enough for a 30-day supply. At just under $90 for a one-time purchase, this is a pretty expensive supplement. However, you can sign up for a subscription, which knocks off $15.
Pros
[*]
+High NMN dosage
[*]
+Excellent absorbency
[*]
+Vegan friendly
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Cons
[*]
-Quite expensive
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Overall Best NMN Supplement
Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend...
2. Best Sublingual NMN Supplement: Renue By Science NMNs
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue by Science provides a range of pharmaceutical-grade NMN supplements in a number of different forms. This company is committed to delivering a high level of absorbency with its products. That is a big deal because many supplements have a very poor rate of absorbency in the body.
The sublingual NMN supplement that Renue offers provides excellent absorption. When I took it under my tongue, I felt the effects in my system a lot faster than when I took a capsule form with similar ingredients. That means that you get a lot more potency for a lower dosage.
Unlike many sublingual supplements, I didn't experience any nasty aftertaste with Renue By Science NMNs. In fact, it has a natural lemonade flavor which I enjoyed, and has an easy-to-absorb texture.
The product also includes natural additives to increase absorption. It's completely free of preservatives and artificial flavors and, as with all Renue by Science products, is 3rd party tested for purity and potency.
Each NMN tablet contains 125 mg of NMN, and you get 240 tablets in each container. The serving size is two tablets, providing you with a 3-month supply.
Renue by Science NMNs is well-priced and, as a bonus, provides free shipping on domestic US orders.
Pros
[*]
+Fast absorbency
[*]
+Pleasant lemonade taste
[*]
+250 mg NMN per serving
[/list]
Cons
[*]
-Does not offer a money-back guarantee
[/list]
Best Sublingual NMN Supplement
These tablets can be chewed or used sublingually (under the tongue). A percentage of the NMN is absorbed directly to the bloodstream and is available to cells...
3. Best Slow-Release NMN Supplement: Nootropics Depot NMN Tablets
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Nootropics Depot NMN Tablets provide a slow release of the NMN into your system. This sustained release provides a longer-lasting effect. This may mean you don't have to take the supplement as often as a faster-release alternative.
Slow-release NMN supplements may also have fewer side effects, according to some research, as well as better absorption, utilization, and the ability to maintain more stable blood sugar levels.
You get 125 mg of NMN with each capsule of Nootropics NMN tablets. That is a relatively low dosage but may be compensated for by the increased absorbency. Each tablet has an enteric coating to further increase the bioavailability. This coating prevents the disintegration of the supplement in the stomach, allowing it to reach the small intestine fully intact.
Nootropics Depot offers this supplement in either a 30 or 60-count jar. The recommended daily dosage is one capsule.
Pros
[*]
+Slow-release form of NMN
[*]
+Increased absorbency
[*]
+Enteric coating to prevent disintegration in the stomach
[/list]
Cons
[*]
-Relatively low NMN dose
[/list]
Best Slow-Release NMN Supplement
The enteric coating on these tablets prevents disintegration of the NMN tablet in the stomach and instead delays tablet disintegration until the NMN tablet reaches the small intestines...
4. Best Powder NMN Supplement: Double Wood NMN Powder
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Double Wood NMN Powder is as pure and simple as it gets. Every serving provides you with 1 gram of NMN powder - and nothing else. With 30 grams in each container, you've got enough for a one-month supply.
This product is vegan friendly and is non-GMO, preservative, gluten, filler, and additive free. Even though the ingredient label gives the dosage as 1 gram, the website recommends breaking that up into several smaller dosages rather than taking it all at once. It is claimed that, due to the short half-life of NMN, taking 3-4 four dosages spaced a couple of hours apart, you will be better able to elevate NAD+ levels.
This powder does a decent job of mixing, but you may be left with a bit of residue if you're just mixing it with a spoon in your glass of water.
One thing I especially appreciate about Double Wood as a supplement manufacturer is that it is very transparent about its products. The company employs a 3rd party laboratory to carry out testing for purity and potency. You can even check the 3rd party testing details on the official website.
Pros
[*]
+3rd party tested
[*]
+1 gram NMN per serving
[*]
+Vegan friendly
[/list]
Cons
[*]
-Doesn't mix overly well
[*]
-No added ingredients
[/list]
Best Powder NMN Supplement
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound that is in small amounts in the human body as well as some foods. NMN is orally bioavailable...
5. Best Budget NMN Supplement: BulkSupplements NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
BulkSupplements have created a thriving business by supplying simple, no-frills health and fitness supplements with basic packaging at a budget price and with top quality. Their NMN supplement is a good example of that business model in action.
I recommend BulkSupplements products to my personal training clients more than any other brand. I do so because, after many years of using their products, I have absolute confidence in the purity and effectiveness of their supplements.
The powder in this NMN supplement mixes well to give you a smooth consistency when you drink it. The recommended serving size for BulkSupplements NMN is 250 mg. With each bag providing you with 10 grams, that gives you enough for 40 servings. You can also buy it in larger, bulk amounts, so long as they are not sold out.
Pros
[*]
+250 mg per serving
[*]
+Trusted brand
[*]
+Very cost-effective
[/list]
Cons
[*]
-No added ingredients
[/list]
Best Budget NMN Supplement
BulkSupplements NMN is a pure form of the nutrient nicotinamide mononucleotide (NMN). NMN is a precursor to NAD+, which is essential for cellular health and anti-aging...
6. Best Liposomal NMN Supplement: Renue By Science Lipo NMN
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Renue By Science Lipo NMN is a powdered form of NMN that contains the liposomal form of the compound. The liposomal delivery system is a technique for supplying the body with nutrients in a way that improves their absorption and bioavailability.
Liposomes are tiny, spherical particles with a lipid bilayer, which resembles the composition of cell membranes. By joining with cell membranes, thanks to this structure, liposomes can transfer their contents directly into the cells.
There are 500 mg of NMN in every serving of Renue By Science Lipo NMN, with a serving being two capsules. Renue uses LIPO Caps™ with this product. These patented caps involve filling liposomes with nanoparticles that are subsequently freeze-dried to eliminate the aqueous phase. This ensures optimal stability and bioavailability while also guarding the ingredients against deterioration.
Pros
[*]
+500 mg NMN per serving
[*]
+Liposomal delivery system
[*]
+LIPO Caps™ for enhanced bioavailability
[*]
+Mixes well
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Cons
[*]
-No added ingredients
[/list]
Best Liposomal NMN Supplement
LIPO NMN features proprietary, powder-based liposomes that protect NMN from digestive enzymes & carry it into the bloodstream for targeted systemic delivery...
7. Best NMN + Resveratrol Supplement: Peak Performance NMN + Resveratrol
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Peak Performance NMN + Resveratrol combines 150 mg of NMN with the same amount of resveratrol to supercharge the supplement's effectiveness. Both resveratrol and NMN have been demonstrated to enhance cellular regeneration and repair procedures that lessen the effects of aging. These compounds may combine to strengthen their anti-aging benefits when taken together.
Resveratrol has been demonstrated to have cardioprotective properties, while NMN may support improved blood vessel function and oxidative stress reduction. Mixing these substances may enhance cardiovascular health in general.
Resveratrol has also been shown in animal studies to enhance cognitive performance, while NMN has been found to assist brain function and repair procedures. Together, these compounds could enhance cognition in general and memory, concentration, and focus in particular.
Peak Performance NMN + Resveratrol is 3rd party tested for purity and potency. It is vegan and allergy free. It is also free of soy, milk, egg, shellfish, corn, wheat & peanuts. It contains no gluten or preservatives. The supplement is manufactured under GMP regulations and USA Standards.
The serving size for Peak Performance NMN + Resveratrol is one vegan capsule, and there are 30 capsules per container.
Pros
[*]
+NMN + Resveratrol
[*]
+Increased absorbency
[*]
+3rd party tested
[/list]
Cons
[*]
-The company is not NSF certified
[/list]
Best NMN + Resveratrol Supplement
Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs...
8. Best Absorbability NMN Supplement: Prohealth Longevity NMN Pro
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Prohealth Longevity NMN Pro provides you with 300 mg of NMN per two-capsule serving. According to the manufacturer, this is the only NMN supplement that has been clinically proven to boost NAD+ levels in humans. In a study, NAD+ levels were increased by 38% in 60 days - the equivalent of a 12-year reversal.
Prohealth has been selling top-quality supplements for 34 years, having established a reputation for quality, purity, and value. I have personally used their supplements for many years and have always been very pleased with the effectiveness of their supplements. The company has an A+ rating with the Better Business Bureau.
Every batch of Prohealth Longevity NMN Pro is 3rd party tested for potency and purity. All 3rd party lab certificates of analysis are publicly posted on the company website. The supplement is manufactured in an FDA-registered, GMP-certified facility in the USA.
Pros
[*]
+300 mg of NMN per serving
[*]
+3rd party tested
[*]
+Confirmed to be effective in a clinical study
[*]
+Vegan friendly
[/list]
Cons
[*]
-Reported to induce sleepiness by some reviewers
[/list]
Best Absorbability NMN Supplement
ProHealth Uthever NMN: The ONLY NMN CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed double blind placebo controlled clinical study...
9. Best Liquid NMN Supplement: Quicksilver Scientific
Ingredients
5.0
Efficacy
5.0
Overall Score: 5.0
Quicksilver Scientific is a liquid form of NMN supplement. Taking NMN in liquid form is believed to provide the greatest absorbency. They may also allow for more precise dosing than taking a powder or capsule form of the supplement. If you have issues swallowing capsules or tablets, liquid may be the best form for you.
Every dose of Quicksilver Scientific gives you 50 mg of NMN, blended with methylation cofactors and sirtuin activators to boost its effectiveness. It includes quercetin, TMG, riboflavin, and vitamin B12, which have been shown to work with NMN to make it more active.
Quicksilver scientific claims that its products utilize the world's most advanced phospholipid delivery system. That means that the core ingredients will get into your body's cells faster.
To be honest, the taste of Quicksilver Scientific is not great. But it doesn't have very much of an aftertaste, so the unpleasantness goes away pretty quickly.
Pros
[*]
+50 mn MNM in liquid form
[*]
+Improved absorbency
[*]
+Advanced phospholipid system
[/list]
Cons
[*]
-Taste is not the best
[/list]
Best Liquid NMN Supplement
NAD+ Platinum is a blend of NMN, methylation cofactors and sirtuin activators. It combines the action of 3 separate products (NAD Gold, Methyl Charge and The One)...
What is NMN?
NMN stands for nicotinamide mononucleotide. The NMN molecule plays a key role in the body's production of energy. NMN is a precursor to the coenzyme NAD+ or nicotinamide adenine dinucleotide. A precursor is a compound that is needed for the body to produce another compound. NAD+ is pivotal to a range of biological processes, including metabolism, gene expression, and DNA repair.
Our bodies naturally produce NMN. However, as we age, that production declines. Supplementing with an NMN supplement can increase those levels to promote higher production of NAD+ in the body.
Supplementing with NMN has been shown to actually be better than taking an NAD+ supplement. That is because NMN molecules are much smaller and are, therefore, better able to be absorbed and utilized by the body.
Benefits of NMN:
In recent years, there has been a lot of research into the benefits of both NMN and NAD+. Here are the eight key benefits of taking an NMN supplement.
1. Increases energy
As stated, NMN is a precursor of NAD+, a coenzyme that is essential for the synthesis of cellular energy. The process by which nutrients are transformed into ATP, the energy-producing molecule for cells, involves NAD+. Supplementing with NMN may help to enhance cellular energy generation and fight fatigue by raising NAD+ levels in the body.
NMN may also assist in enhancing muscle performance and reducing exhaustion during workouts. In one study, NMN supplementation in mice enhanced endurance and decreased fatigue during physical activity.
By accelerating the body's breakdown of fats and sugars, NMN may help boost metabolism. This increases calorie burn to produce more energy.¹ ²
2. Revitalizes blood vessels
Blood flow and blood pressure are significantly influenced by endothelial cells, which line the interior of our blood arteries. A body of clinical research suggests that NMN supplementation may assist in enhancing endothelial function, which will increase blood flow and lower the risk of cardiovascular disease.
According to some studies, NMN supplementation may help to reduce inflammation in the body. Chronic inflammation is a key risk factor for cardiovascular disease. NMN may improve overall cardiovascular health by decreasing inflammation and defending blood vessels from harm.
Nitric oxide is a chemical that is important for numerous physiological functions, including controlling blood flow and blood pressure. According to some research, using NMN supplements may help to boost nitric oxide levels.
One study used a mouse model of ischemia-reperfusion injury to look at how NMN affected the heart. The study's findings—which were supported by improved blood vessel function, higher blood flow, and decreased oxidative stress—show that NMN supplementation lessened the severity of the heart injury and improved blood vessel function. According to the researchers, NMN might be useful as a therapeutic drug to enhance blood vessel function and lower cardiovascular risk.³ ?
3. Improves Memory
As we age, our bodies produce less NMN. This may contribute to age-related cognitive decline, increasing memory loss. NMN supplementation has been shown to increase mitochondrial function inside the cell. Some researchers believe that this helps with cognitive functioning.
Higher levels of NAD+ result in reduced oxidative stress. This, too, has been associated with improved cognitive performance, including better memory.
In one study, NMN's impact on brain damage caused by global cerebral ischemia in mice was examined. The researchers discovered that NMN supplementation decreased brain damage and enhanced cognitive performance, as shown by improved memory in a test of fear conditioning. The researchers hypothesized that NMN could have potential as a therapeutic drug for enhancing cognitive performance and lessening the symptoms of brain damage.?
4. Boosts metabolism
NAD+ is essential in the synthesis and utilization of cellular energy. NMN supplementation may support a healthy metabolism and the production of energy since it raises the body's levels of NAD+.
Mitochondria are the organelles in cells that produce energy through cellular respiration. An increased mitochondrial function may result in enhanced energy production and metabolism when NMN supplementation is used.
Persistent inflammation contributes to a range of diseases, including metabolic dysfunction, Type 2 diabetes, and obesity. Research shows that reducing inflammation by taking an NMN supplement may boost metabolic health.
Supplementing NMN may also increase insulin sensitivity. This could result in increased energy production.? ?
5. May Increase fertility
By promoting healthy mitochondrial function and energy production, NMN supplementation might help to improve ovarian function. Women who are suffering from ovarian function decline brought on by aging may find this to be helpful.
Oocytes, also known as egg cells, are what sperm fertilize in the womb. Oocyte quality has been seen to be improved by increased NAD+ levels. The chances of a successful conception may, therefore, increase as a result of NMN supplementation, according to research.
By harming cells and DNA, oxidative stress can cause infertility. According to some research, using NMN supplements may help women have healthier fertility and less oxidative stress.
Although the majority of studies on NMN and fertility have focused on women, several studies have suggested that NMN supplementation may also have benefits for men. According to one study, NMN supplementation may increase sperm count in mice.?
6. Repairs DNA damage
Due to its involvement in the activity of enzymes that aid in the repair of damaged DNA, NAD+ is essential for DNA repair. The activities involved in DNA repair may be supported by NMN supplementation since it raises the body's levels of NAD+.
NMN supplementation may help in improving cellular energy generation by promoting healthy mitochondrial function, which is necessary for the energy-intensive DNA repair processes. Cells that are actively mending DNA damage might benefit from this.
Because oxidative stress can harm DNA, lowering it may aid in the processes that support DNA repair. According to some studies, taking NMN supplements may help the body lower oxidative stress levels, which may support DNA repair.
One study looked at how giving NMN to animals with muscular dystrophy affected DNA damage and repair mechanisms. The researchers discovered that NMN supplementation increased DNA repair mechanisms, resulting in reduced DNA damage and enhanced muscle performance. The researchers hypothesized that NMN supplementation might have therapeutic potential for enhancing DNA repair mechanisms and minimizing DNA damage.? ¹?
7. May improve stem cell health
NAD+ has a role to play in regulating stem cell function. NMN's ability to increase NAD+ levels means that it may help improve stem cell health. The mitochondria in cells, which are key to energy production, are also necessary for stem cell health. NMN supplementation, as we have already noted, helps to improve mitochondrial activity.
There is also some evidence to imply that NMN supplementation may help to reduce cellular senescence, or aging and death, in stem cells. Other research suggests that NMN supplementation may help to improve stem cell function and support tissue regeneration.
In one study, the effects of NMN on stem cell function both in vitro and in vivo were examined. The proliferating, migrating, and differentiating potential of stem cells increased after NMN administration. Also, they discovered that NMN supplementation enhanced stem cell performance in vivo, as shown by animals with increased tissue regeneration and wound repair. The scientists hypothesized that NMN would be useful as a medicinal drug for enhancing stem cell performance and encouraging tissue regeneration.¹¹
8. May Prevent age-related changes in gene expression
Age-related declines in NAD+ levels are common, and NAD+ is essential for controlling gene expression. Supplementing with NMN may maintain healthy gene expression and fend off age-related alterations by raising levels of NAD+ in the body.
Epigenetic alterations, which affect gene expression without affecting the DNA sequence itself, are crucial in the aging process and the development of age-related illnesses. According to some studies, using NMN supplements could assist in improving epigenetic control, which would result in healthier gene expression patterns.
Age-related changes in gene expression can be attributed to chronic inflammation. According to some studies, using NMN supplements may assist in lowering inflammation in the body, which may avoid changes in gene expression brought on by aging.
The effects of NMN supplementation on gene expression, mitochondrial function, and lifespan in mice were examined in one study. The research team discovered that NMN supplementation stopped age-related changes in gene expression, resulting in better mitochondrial function and a longer life span. The study authors hypothesized that NMN would be useful as a therapeutic drug for encouraging healthy aging and avoiding age-related alterations in gene expression.¹² ¹³
Side Effects of NMN
When taken according to recommended dosage guidelines, NMN supplementation is safe with no major side effects. As with any supplement, however, there is the possibility of some minor side effects. These may include:
- Nausea
- Diarrhea
- Indigestion
- Flushing/redness of the skin
- Headaches or migraine
- Insomnia
What to look for when buying NMN supplements:
To make sure that you get an NMN supplement that provides the quality and effectiveness you deserve, you need to follow a few buying guidelines. Here are seven key things to consider:
1. Ingredients
Obviously, nicotinamide mononucleotide should be the main ingredient in an NMN supplement. While there is only one form of NMN, some supplements may include other ingredients that are designed to work synergistically alongside NMN to boost its effectiveness. Here are five ingredients that are commonly added to NMN supplements:
Resveratrol: The chemical resveratrol is thought to boost the effects of NMN. It is derived from peanuts, red grapes, and other plants.
Polyphenols: Plant components known as polyphenols have antioxidant capabilities and may enhance general health and wellness. Other polyphenols like quercetin or catechins may also be present in some NMN supplements.
Vitamins and minerals: Certain NMN supplements may include extra vitamins and minerals, such as magnesium or vitamin D, that are thought to improve general health and wellness.
Nucleotides: Nicotinamide riboside (NR), another precursor to NAD+, is one of the additional nucleotides that some NMN supplements may contain.
When purchasing an NMN supplement, it's important to carefully read the administration guidelines and search for the suggested dosage on the label. Clinical studies typically use daily dosages of 100-500mg, while some participants may get higher levels.
3. Delivery Method
NMN supplements come in a variety of forms, each of which has advantages and disadvantages. Here's an overview of the various delivery methods:
NMN Capsules: Many NMN supplements come in capsule form, which makes them convenient and easy to take. It is easier to...
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