ANDROXAL – THE FUTURE OF TESTOSTERONE REPLACEMENT THERAPY
by Tuned Sports
Secondary hypogonadism is an unfortunate reality for many men. It is a natural condition that comes with age. The two parts of the brain; the hypothalamus and the pituitary gland which regulate testosterone production become less functional as a result of disease, inflammation, obesity, medications, but mostly as a result of aging. As many as 40% of men aged 45 or older will experience hypogonadism (1). Steroid users are at an even greater risk of attaining hypogonadism earlier in life. Being deficient in testosterone is not a pleasant experience by any means. Hypogonadal men may experience loss of muscle mass, low energy levels and libido, weak bone density, and be more prone to gaining fat mass. In recent times the benefits of Testosterone Replacement Therapy (TRT) have become alluring for many men; improvement in energy levels, libido, concentration, bone density, and an increase in muscle mass and decrease in fat mass. While TRT may improve the symptoms of low testosterone, it does not come without a price tag. Current TRT programs administer testosterone via weekly injections or by transdermal applications. Both routes have their drawbacks. The idea of performing weekly injections for years on end is not appealing for anyone and transdermal east inflatables blog applications can be easily passed by contact. Furthermore, the administration of exogenous testosterone causes the testicles to shrink and become non-functional further damaging the HPTA axis. This leads to infertility and a poor metabolic state negatively affecting Thyroid-stimulating hormone (TSH), Adrenocorticotropic hormone (ACTH), cortisol, and lipids. .In comes Androxal: an oral drug which causes the pituitary to release LH and FSH and in turn stimulates the testicles to produce testosterone. Thus the user actually experiences an increase in fertility, testicular function, and does not have to worry about being in a poor metabolic state.
Androxal has been shown to posses all the positive benefits of AndroGel without the negatives side effects. In a study involving 44 men Androxal (25mg) increased serum testosterone levels to an average of 604 ng/dL while AndroGel increased serum testosterone levels to an average of 500 ng/dL after six weeks of continuous use (2). There is no potential for abuse with Androxal and it is not a controlled substance. Androxal is currently in phase 3 trials which are the final trials for confirming safety and efficacy before launch. Earlier this month, Bank of America initiated a buy on Repros Therapeutics, the makers of Androxal knowing full well it has potential to be the best method of TRT on the market. So, what exactly is Androxal? It is an orally active single isomer of clomiphene citrate (clomid). Androxal constitutes the trans-stereoisomer of clomiphene citrate known as enclomiphene. It took long enough for the medical community to notice…
tagged with androxal, hypogonadism, testosterone replacement therapy, trt
by Tuned Sports
Secondary hypogonadism is an unfortunate reality for many men. It is a natural condition that comes with age. The two parts of the brain; the hypothalamus and the pituitary gland which regulate testosterone production become less functional as a result of disease, inflammation, obesity, medications, but mostly as a result of aging. As many as 40% of men aged 45 or older will experience hypogonadism (1). Steroid users are at an even greater risk of attaining hypogonadism earlier in life. Being deficient in testosterone is not a pleasant experience by any means. Hypogonadal men may experience loss of muscle mass, low energy levels and libido, weak bone density, and be more prone to gaining fat mass. In recent times the benefits of Testosterone Replacement Therapy (TRT) have become alluring for many men; improvement in energy levels, libido, concentration, bone density, and an increase in muscle mass and decrease in fat mass. While TRT may improve the symptoms of low testosterone, it does not come without a price tag. Current TRT programs administer testosterone via weekly injections or by transdermal applications. Both routes have their drawbacks. The idea of performing weekly injections for years on end is not appealing for anyone and transdermal east inflatables blog applications can be easily passed by contact. Furthermore, the administration of exogenous testosterone causes the testicles to shrink and become non-functional further damaging the HPTA axis. This leads to infertility and a poor metabolic state negatively affecting Thyroid-stimulating hormone (TSH), Adrenocorticotropic hormone (ACTH), cortisol, and lipids. .In comes Androxal: an oral drug which causes the pituitary to release LH and FSH and in turn stimulates the testicles to produce testosterone. Thus the user actually experiences an increase in fertility, testicular function, and does not have to worry about being in a poor metabolic state.
Androxal has been shown to posses all the positive benefits of AndroGel without the negatives side effects. In a study involving 44 men Androxal (25mg) increased serum testosterone levels to an average of 604 ng/dL while AndroGel increased serum testosterone levels to an average of 500 ng/dL after six weeks of continuous use (2). There is no potential for abuse with Androxal and it is not a controlled substance. Androxal is currently in phase 3 trials which are the final trials for confirming safety and efficacy before launch. Earlier this month, Bank of America initiated a buy on Repros Therapeutics, the makers of Androxal knowing full well it has potential to be the best method of TRT on the market. So, what exactly is Androxal? It is an orally active single isomer of clomiphene citrate (clomid). Androxal constitutes the trans-stereoisomer of clomiphene citrate known as enclomiphene. It took long enough for the medical community to notice…
- Mulligan T, Frick MF, Zuraw QC, et al. Prevalence of hypogonadism in males aged at least 45 years: The HIM study. Int J Clin Pract 2006;60:762-769.
- Wiehle R. et al. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. DOI: 10.1111/bju.12363
tagged with androxal, hypogonadism, testosterone replacement therapy, trt
