[h=2]Cabergoline is used for:[/h]<!-- start 300 ad -->
<!-- end 300 ad --> Treating disorders associated with high levels of the hormone prolactin, either due to tumors in the pituitary gland or to unknown causes. It may also be used for other conditions as determined by your doctor.
Cabergoline is a dopamine receptor agonist. It works by blocking prolactin secretion from the pituitary gland.
[h=2]Do NOT use cabergoline if:[/h]
- you are allergic to any ingredient in cabergoline or to ergot derivatives (eg, ergotamine)
- you have uncontrolled high blood pressure
- you have a history of heart valve problems or certain fibrotic (scarring) disorders (eg, of the lung, heart, kidneys)
- you are taking a butyrophenone (eg, haloperidol), metoclopramide, a phenothiazine (eg, chlorpromazine), or a thioxanthene (eg, thiothixene)
- you have taken or will be taking a "triptan" (eg, sumatriptan) within 24 hours before or after taking cabergoline
Contact your doctor or health care provider right away if any of these apply to you
[h=2]Before using cabergoline:[/h]Some medical conditions may interact with cabergoline. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver problems or high blood pressure
- if you have developed high blood pressure caused by pregnancy
- if you take any medicine that may lower blood pressure or cause heart valve problems. Check with your doctor or pharmacist if you are unsure if any of your medicines may lower blood pressure or cause heart valve problems
Some MEDICINES MAY INTERACT with cabergoline. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Macrolides (eg, clarithromycin) because they may increase the risk of cabergoline's side effects
- Butyrophenones (eg, haloperidol), metoclopramide, phenothiazines (eg, chlorpromazine), or thioxanthenes (eg, thiothixene) because they may decrease cabergoline's effectiveness
- "Triptans" (eg, sumatriptan) because the risk of their side effects may be increased by cabergoline
This may not be a complete list of all interactions that may occur. Ask your health care provider if cabergoline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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[h=3]Major Side Effects[/h]
You should check with your doctor immediately if any of these side effects occur when taking cabergoline:
Less common:
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chills
- cold sweats
- confusion
- dizziness, faintness, or lightheadedness when getting up from lying or sitting position
- fast, irregular, pounding, or racing heartbeat or pulse
- general feeling of discomfort or illness
- rapid weight gain
- swelling around the eyes
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
Incidence not known:
- Chest pain or tightness
- continuing loss of appetite
- continuing or severe abdominal or stomach pain
- continuing or severe nausea and vomiting
- cough
- decreased ability to exercise
- fever
- increased frequency of urination
- loss of appetite
- lower abdominal or stomach pain
- lower back pain
- nausea
- shortness of breath
- trouble with breathing
- vomiting
- weakness
If any of the following symptoms of overdose occur while taking cabergoline, get emergency help immediately:
Symptoms of overdose:
- Fainting
- seeing, hearing, or feeling things that are not there
- stuffy nose
[h=3]Minor Side Effects[/h]Some of the side effects that can occur with cabergoline may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Difficulty having a bowel movement (stool)
- dizziness
- excess air or gas in the stomach or intestines
- full feeling
- headache
- lack or loss of strength
- passing gas
Less common:
- Abdominal or stomach pain
- acid or sour stomach
- anxiety
- belching
- blemishes on the skin
- breast pain
- burning, itching, or stinging of the skin
- changes in vision
- cramps
- depression
- diarrhea
- difficulty with moving
- dry mouth or toothache
- feeling of constant movement of self or surroundings
- feeling of warmth
- gas
- heartburn
- heavy bleeding
- indigestion
- itching skin
- joint pain
- muscle aches and pains
- muscle stiffness
- pimples
- redness of the face, neck, arms, and occasionally, upper chest
- runny nose
- sensation of spinning
- shivering
- sleeplessness
- sleepiness or unusual drowsiness
- sneezing
- sore throat
- stomach discomfort or upset
- sudden sweating
- trouble with sleeping
- unable to sleep
- weight loss
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Rare
- Bloody nose
- difficulty in concentrating
- increased in sexual ability, desire, drive, or performance
- increased interest in sexual intercourse
Incidence not known:
- Attack, assault, or force
- feeling that others are watching you or controlling your behavior
- feeling that others can hear your thoughts
- hair loss or thinning of the hair
- pathological gambling
- severe mood or mental changes
- unusual behavior
<!-- end oral tablet -->[h=2]For Healthcare Professionals[/h]
Applies to cabergoline: oral tablet
[h=3]Gastrointestinal[/h]Very common (10% or more): Nausea (up to 29%)
Common (1% to 10%): Constipation, dyspepsia, gastritis, vomiting, abdominal pain, dyspepsia, dry mouth, diarrhea, flatulence, throat irritation, toothache[SUP]
[Ref][/SUP]
[h=3]Nervous system[/h]Very common (10% or more): Headache (up to 26%), dizziness (up to 17%)
Common (1% to 10%): Dizziness/vertigo, dyskinesia, paresthesia, somnolence
Uncommon (0.1% to 1%): Hyperkinesia
Frequency not reported: Sudden sleep onset, syncope, tremor[SUP]
[Ref][/SUP]
[h=3]Other[/h]Common (1% to 10%): Asthenia
Uncommon (0.1% to 1%): Fatigue, malaise[SUP]
[Ref][/SUP]
[h=3]Psychiatric[/h]Common (1% to 10%): Hallucinations sleep disturbance, increased libido, confusion, depression, anxiety, insomnia, nervousness
Uncommon (0.1% to 1%): Delusions, psychotic disorder
Frequency not reported: Aggression, hypersexuality, pathological gambling[SUP]
[Ref][/SUP]
[h=3]Cardiovascular[/h]Very common (10% or more): Peripheral edema
Common (1% to 10%): Angina (with concomitant levodopa use), postural hypotension, hot flashes, cardiac valvulopathy, hypotension, dependent edema, palpitation
Uncommon (0.1% to 1%): Erythromelalgia
Rare (less than 0.1%): Syncope, heart failure
Frequency not reported: Constrictive pericarditis, digital vasospasm
Postmarketing reports: Cardiac valvulopathy, pericarditis, pericardial effusion[SUP]
[Ref][/SUP]
Reports of cardiac valvulopathy have generally been received in patients on higher doses (greater than 2 mg/day); however, there have been cases in patients receiving lower doses for the treatment of hyperprolactinemic disorders. In a multi-country, retrospective cohort study, record review looking for an association between the new use of dopamine agonists (including this drug; n=27,812) and cardiac valvular regurgitation (CVR), other fibrosis, and other cardiopulmonary events found an increased risk of CVR among patients with Parkinson's disease when compared to non-ergot derived dopamine agonists and levodopa. Analysis in patients with hyperprolactinemia treated with this drug (n=8386) found that compared to non-users, exposed persons did not have an elevated risk of CVR. These findings are consistent with other published studies.[SUP]
[Ref][/SUP]
[h=3]Musculoskeletal[/h]Frequency not reported: Leg cramps[SUP]
[Ref][/SUP]
[h=3]Dermatologic[/h]Uncommon (0.1% to 1%): Rash, acne, pruritus
Frequency not reported: Alopecia[SUP]
[Ref][/SUP]
<ins class="adsbygoogle adsense-ad adsense-ad-injection adsense-ad-text-image adsense-ad-300 adsense-ad-300-250" style="width: 300px; height: 250px; display: block;" data-adsbygoogle-status="done" data-ad-channel="4849241754" data-ad-type="text,image" data-color-border="ffffff" data-color-bg="ffffff" data-color-link="0000ff" data-color-text="000000" data-color-url="008000" data-analytics-domain-name="drugs.com" data-ad-client="pub-3964816748264478"><ins id="aswift_2_expand" style="margin: 0px; padding: 0px; border: currentColor; width: 300px; height: 250px; display: inline-table; visibility: visible; position: relative; background-color: transparent; border-image: none;"><ins id="aswift_2_anchor" style="margin: 0px; padding: 0px; border: currentColor; width: 300px; height: 250px; display: block; visibility: visible; position: relative; background-color: transparent; border-image: none;"><iframe name="aswift_2" width="300" height="250" id="aswift_2" frameBorder="0" marginWidth="0" marginHeight="0" scrolling="no" vspace="0" hspace="0" allowfullscreen="true" style="left: 0px; top: 0px; width: 300px; height: 250px; position: absolute;" allowTransparency="true"></iframe></ins></ins></ins>[h=3]Respiratory[/h]Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Pleural effusion, pulmonary fibrosis, rhinitis
Very rare (less than 0.01%): Fibrosis (including pleural fibrosis)
Frequency not reported: Respiratory disorder, respiratory failure, pleuritic, chest pain[SUP]
[Ref][/SUP]
[h=3]Ocular[/h]Uncommon (0.1% to 1%): Periorbital edema, abnormal vision[SUP]
[Ref][/SUP]
[h=3]Endocrine[/h]Common (1% to 10%): Breast pain
Uncommon (0.1% to 1%): Dysmenorrhea[SUP]
[Ref][/SUP]
[h=3]General[/h]Adverse effects are generally dose related. At lower doses, the more commonly reported adverse reactions included nausea, headache, dizziness/vertigo, abdominal pain/dyspepsia/gastritis, asthenia/fatigue; at higher doses, additional events of valvulopathy, dyspnea, dyskinesia, orthostatic hypotension, hallucination, and constipation have been commonly reported.[SUP]
[Ref][/SUP]
[h=3]Hepatic[/h]Uncommon (0.1% to 1%): Hepatic function abnormalities
Postmarketing reports: Liver function test abnormal[SUP]
[Ref][/SUP]
[h=3]Hypersensitivity[/h]Uncommon (0.1% to 1%): Hypersensitivity reaction[SUP]
[Ref][/SUP]
[h=4]References[/h]1. "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn, Kalamazoo, MI.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Multum Information Services, Inc. Expert Review Panel"
