Have you ever heard of Bremelanotide?
In this article, I’ll reveal how Bremelanotide can boost libido and potentially aid with erections.
Bremelanotide is a melanocortin receptor agonist, functioning similarly to MSH. It’s FDA-approved for women with hypoactive sexual desire disorder and is taken 45 minutes to an hour before sex and remarkably, it works on the brain.
The melanocortin system regulates various functions, including appetite, pain sensation, skin color, and sexual activity. Essentially, melanocortins send excitatory signals to brain areas like the cortex and thalamus, increasing sexual receptiveness.
Initial animal studies on melanocyte-stimulating hormone showed increased sexual receptiveness, revealing two key findings:
1. Increased nitric oxide in the genitals, igniting erections and sexual activity.
2. Dilation of blood vessels, enhancing blood flow to the genitals.
This led to the development of Bremelanotide (PT-141). Approved for premenopausal women. Functional MRI studies showed that Bremelanotide activates brain areas usually less active in those with hypoactive sexual desire disorder. This resulted in increased arousal when exposed to erotic stimuli and decreased self-consciousness. Majority of the women studied experienced increased sexual desire for up to 24 hours, with a 2.5 times higher response rate compared to placebo.
Bremelanotide also slightly reduced hunger in some women. Larger clinical trials confirmed these effects, showing a 2.6 times increase in sexual desire. The medication is recommended once within 24 hours, no more than 8 times a month, and must be used with birth control due to unknown effects on a fetus. It’s contraindicated for those with uncontrolled high blood pressure or heart disease. The most common side effect is nausea, affecting up to 40% of women, which can be managed with antiemetics. Other side effects include flushing, headaches, vomiting, and minor hyperpigmentation
But what about men?
Bremelanotide has been studied for low libido and erectile dysfunction in men, with trials involving 19 to 342 patients. Men who took Bremelanotide, either as a nasal spray or injection, experienced increased desire, erection rigidity, duration, and satisfaction. In a study of 342 married men, those who took 10 mg of Bremelanotide showed a positive response in 33% of cases, compared to 8% in the placebo group.
Despite promising results, Bremelanotide is not yet FDA-approved for men’s low desire or erectile dysfunction. However, it is sometimes prescribed off-label. Anecdotally, Bremelanotide significantly boosts sexual desire, which can be uncomfortable if sex isn’t possible. Some users report nausea and cold-like symptoms post-use.
If you have severe high blood pressure or heart disease, it’s best to avoid Bremelanotide. Consult a urologist or sexual medicine expert if you’re considering it, to ensure safe and effective use.
In this article, I’ll reveal how Bremelanotide can boost libido and potentially aid with erections.
Bremelanotide is a melanocortin receptor agonist, functioning similarly to MSH. It’s FDA-approved for women with hypoactive sexual desire disorder and is taken 45 minutes to an hour before sex and remarkably, it works on the brain.
The melanocortin system regulates various functions, including appetite, pain sensation, skin color, and sexual activity. Essentially, melanocortins send excitatory signals to brain areas like the cortex and thalamus, increasing sexual receptiveness.
Initial animal studies on melanocyte-stimulating hormone showed increased sexual receptiveness, revealing two key findings:
1. Increased nitric oxide in the genitals, igniting erections and sexual activity.
2. Dilation of blood vessels, enhancing blood flow to the genitals.
This led to the development of Bremelanotide (PT-141). Approved for premenopausal women. Functional MRI studies showed that Bremelanotide activates brain areas usually less active in those with hypoactive sexual desire disorder. This resulted in increased arousal when exposed to erotic stimuli and decreased self-consciousness. Majority of the women studied experienced increased sexual desire for up to 24 hours, with a 2.5 times higher response rate compared to placebo.
Bremelanotide also slightly reduced hunger in some women. Larger clinical trials confirmed these effects, showing a 2.6 times increase in sexual desire. The medication is recommended once within 24 hours, no more than 8 times a month, and must be used with birth control due to unknown effects on a fetus. It’s contraindicated for those with uncontrolled high blood pressure or heart disease. The most common side effect is nausea, affecting up to 40% of women, which can be managed with antiemetics. Other side effects include flushing, headaches, vomiting, and minor hyperpigmentation
But what about men?
Bremelanotide has been studied for low libido and erectile dysfunction in men, with trials involving 19 to 342 patients. Men who took Bremelanotide, either as a nasal spray or injection, experienced increased desire, erection rigidity, duration, and satisfaction. In a study of 342 married men, those who took 10 mg of Bremelanotide showed a positive response in 33% of cases, compared to 8% in the placebo group.
Despite promising results, Bremelanotide is not yet FDA-approved for men’s low desire or erectile dysfunction. However, it is sometimes prescribed off-label. Anecdotally, Bremelanotide significantly boosts sexual desire, which can be uncomfortable if sex isn’t possible. Some users report nausea and cold-like symptoms post-use.
If you have severe high blood pressure or heart disease, it’s best to avoid Bremelanotide. Consult a urologist or sexual medicine expert if you’re considering it, to ensure safe and effective use.
