drtbear1967
Musclechemistry Board Certified Member
theguerillachemist[/URL]
Despite SARMs being pulled from the market, I still keep tabs on all the new and promising ones looking to hit clinical trials. This one by Eli Lilly caught my eye. Despite it being a topical(for now), it has some very promising data. Known as Compound 6, it has a very high affinity for the AR, which is what we want as a SARM, but it also seemed to have very little-to-no interaction (>400 fold selectivity) with the glucocorticoid, mineralcorticoid, and progesterone receptors. In fact, it has only about an order of magnitude difference from binding to AR than the strongest steroid ever made, methyltrienolone. Compound 6 also had a strong anabolic effect-in rats 0.3mg/kg topically was equal to 10mg/kg of test propionate(IM not topical). This equates to about 3.5mg of compound 6 daily to elicit anabolic effects. You'll see in the chart, it's also very selective towards muscle tissue and not prostate tissue(what a SARM should do), and roughly 1mg/kg daily can yield the same anabolic effect as 10mg/kg per week of test prop. Looks like we're getting closer to the elusive pure anabolic.
Despite SARMs being pulled from the market, I still keep tabs on all the new and promising ones looking to hit clinical trials. This one by Eli Lilly caught my eye. Despite it being a topical(for now), it has some very promising data. Known as Compound 6, it has a very high affinity for the AR, which is what we want as a SARM, but it also seemed to have very little-to-no interaction (>400 fold selectivity) with the glucocorticoid, mineralcorticoid, and progesterone receptors. In fact, it has only about an order of magnitude difference from binding to AR than the strongest steroid ever made, methyltrienolone. Compound 6 also had a strong anabolic effect-in rats 0.3mg/kg topically was equal to 10mg/kg of test propionate(IM not topical). This equates to about 3.5mg of compound 6 daily to elicit anabolic effects. You'll see in the chart, it's also very selective towards muscle tissue and not prostate tissue(what a SARM should do), and roughly 1mg/kg daily can yield the same anabolic effect as 10mg/kg per week of test prop. Looks like we're getting closer to the elusive pure anabolic.
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