akn
Musclechemistry Member
Description:
Liothyronine sodium is a synthetically manufactured
prescription thyroid hormone. It specially consists of the Lisomer
of the natural thyroid hormone triiodothyronine
(T3).Thyroid hormones stimulate basal metabolic rate, and
are involved with many cellular functions including
protein, fat, and carbohydrate metabolism. Liothyronine
sodium is used medically to treat hypothyroidism, a
condition where the thyroid gland does not produce
sufficient levels of thyroid hormone. Hypothyroidism is
usually diagnosed with a serum hormone profile (T3, T4, &
TSH),and may manifest itself with symptoms including loss
of energy, lethargy, weight gain, hair loss, and changes in
skin texture. T3 is the most active thyroid hormone in the
body, and consequently liothyronine sodium is considered
to be a more potent thyroid medication than levothyroxine
sodium (T4).
Bodybuilders and athletes are attracted to liothyronine
sodium for its ability to increase metabolism and support
the breakdown of body fat. Most often utilized during
contest preparation or periods of IIcutting': the drug is
usually said to significantly aid in the loss of fat, often on
higher levels of caloric intake than would normally be
permissive of such fat loss. To this end, the drug is also
commonly used in conjunction with other fat loss agents
such as human growth hormone or beta agonists. Some
users also ascribe an ability of thyroid hormones like
liothyronine sodium to increase the anabolic effect of
steroids. While in theory these drugs may support the
greater utilization of protein and carbohydrates for muscle
growth, they are not widely proven or accepted for this
purpose.
History:
The first medication that included T3 was technically a
thyroid extract, first given to a patient with myxedema (a
skin disorder associated with hypothyroidism) in 1891.875
Natural thyroid extracts contained therapeutically viable
levels of the thyroid hormones T3 and T4, and were widely
used in medical practice for more than 60 years. In the
1950s, however, these drugs slowly start giving way to new
synthetic thyroid medications, namely Iiothyronine sodium
and levothyroxine sodium, which were consistent in
dosage and effect, and more desirable to consumers than
prepared animal extracts. Although Iiothyronine sodium
and levothyroxine sodium are both widely available in the
U.S. and abroad to this day, liothyronine retains a
significantly smaller portion of the global thyroid market.
Given its more potent and fast acting effect, however,
liothyronine sodium remains a popular thyroid drug with bodybuilders and athletes. Cytomel® is the most
recognized trade name for the drug in the U.S, where it is
presently sold under the King Pharmaceuticals brand
name.
How Supplied:
Liothyronine sodium is most commonly supplied in oral
tablets of 5 mcg, 25 mcg, and 50 mcg.
Structural Characteristics:
Liothyronine sodium is a synthetic form of T3 thyroid
hormone. It has the chemical designation l-tyrosine,0-(4hydroxy-
3-iodophenyl)-3,5-diiodo-,monosodium salt.
Warnings:
FDA requires the following black box warning accompany
prescription liothyronine sodium products sold in the U.S.:
IIDrugs with thyroid hormone activity, alone or together
with other therapeutic agents, have been used for the
treatment of obesity. In euthyroid patients, doses within
the range of daily hormonal requirements are ineffective
for weight reduction. Larger doses may produce serious or
even life-threatening manifestations of toxicity, particularly
when given in association with sympathomimetic amines
such as those used for their anorectic effects."
Side Effects:
Side effects are generally associated with overdosage, and
may include headache, irritability, nervousness, sweating,
irregular heartbeat, increased bowel motility, or menstrual
irregularities. Overdosage may also induce shock, and may
aggravate or trigger angina or congestive heart failure.
Chronic overexposure to liothyronine sodium will produce
symptoms normally associated with hyperthyroidism or
the overproduction of natural thyroid hormones in the
body.The occurrence of overexposure-linked side effects is
normally cause to immediately reduce or discontinue
therapy with liothyronine sodium. Acute massive overdose
may be life threatening.
Administration:
When used to treat mild hypothyroidism, the typical
recommended starting dosage is 25 mcg daily. The daily
dosage then may be increased by no more than 25 mcg
every 1 to 2 weeks. The established maintenance dose is
usually 25-75 mcg per day. Once a day administration of
the full daily dose is usually recommended. Although
liothyronine sodium is fast acting, its effects may persist in
the body for several days after discontinuance.
The usual protocol among bodybuilders and athletes
taking liothyronine sodium to accelerate fat loss involves
initiating its use with a dosage of 25 mcg per day. This
dosage may be increased by 25 meg every 4 to 7 days,
usually reaching a maximum of no more than 75 mcg per
day. As in a medical setting, the intent of this slow buildup
is to help the body become adjust to the increasing
thyroid hormone levels, and avoid sudden changes that
may initiate side effects.
Cycles of liothyronine sodium usually last no longer than
6 weeks, and administration of the drug should not be
halted abruptly. Instead, it is discontinued in the same
slow manner in which it was initiated. This usually entails
reducing the dosage by 25 meg every 4 to 7 days. This
tapering is done so that the body has time to readjust its
endogenous hormone production at the conclusion of
therapy, and to avoid the onset of side effects.
Availability:
Liothyronine is an old and widely prescribed medication.
It can be found readily in most areas of the world, and is
sold in a variety of different brand and generic forms.
Counterfeiting is not a large-scale problem. It is important
to note than one should never purchase an injectable
form of this drug. These are generally used as emergency
room products only, with potentially very dangerous side
effects if misused.
Liothyronine sodium is a synthetically manufactured
prescription thyroid hormone. It specially consists of the Lisomer
of the natural thyroid hormone triiodothyronine
(T3).Thyroid hormones stimulate basal metabolic rate, and
are involved with many cellular functions including
protein, fat, and carbohydrate metabolism. Liothyronine
sodium is used medically to treat hypothyroidism, a
condition where the thyroid gland does not produce
sufficient levels of thyroid hormone. Hypothyroidism is
usually diagnosed with a serum hormone profile (T3, T4, &
TSH),and may manifest itself with symptoms including loss
of energy, lethargy, weight gain, hair loss, and changes in
skin texture. T3 is the most active thyroid hormone in the
body, and consequently liothyronine sodium is considered
to be a more potent thyroid medication than levothyroxine
sodium (T4).
Bodybuilders and athletes are attracted to liothyronine
sodium for its ability to increase metabolism and support
the breakdown of body fat. Most often utilized during
contest preparation or periods of IIcutting': the drug is
usually said to significantly aid in the loss of fat, often on
higher levels of caloric intake than would normally be
permissive of such fat loss. To this end, the drug is also
commonly used in conjunction with other fat loss agents
such as human growth hormone or beta agonists. Some
users also ascribe an ability of thyroid hormones like
liothyronine sodium to increase the anabolic effect of
steroids. While in theory these drugs may support the
greater utilization of protein and carbohydrates for muscle
growth, they are not widely proven or accepted for this
purpose.
History:
The first medication that included T3 was technically a
thyroid extract, first given to a patient with myxedema (a
skin disorder associated with hypothyroidism) in 1891.875
Natural thyroid extracts contained therapeutically viable
levels of the thyroid hormones T3 and T4, and were widely
used in medical practice for more than 60 years. In the
1950s, however, these drugs slowly start giving way to new
synthetic thyroid medications, namely Iiothyronine sodium
and levothyroxine sodium, which were consistent in
dosage and effect, and more desirable to consumers than
prepared animal extracts. Although Iiothyronine sodium
and levothyroxine sodium are both widely available in the
U.S. and abroad to this day, liothyronine retains a
significantly smaller portion of the global thyroid market.
Given its more potent and fast acting effect, however,
liothyronine sodium remains a popular thyroid drug with bodybuilders and athletes. Cytomel® is the most
recognized trade name for the drug in the U.S, where it is
presently sold under the King Pharmaceuticals brand
name.
How Supplied:
Liothyronine sodium is most commonly supplied in oral
tablets of 5 mcg, 25 mcg, and 50 mcg.
Structural Characteristics:
Liothyronine sodium is a synthetic form of T3 thyroid
hormone. It has the chemical designation l-tyrosine,0-(4hydroxy-
3-iodophenyl)-3,5-diiodo-,monosodium salt.
Warnings:
FDA requires the following black box warning accompany
prescription liothyronine sodium products sold in the U.S.:
IIDrugs with thyroid hormone activity, alone or together
with other therapeutic agents, have been used for the
treatment of obesity. In euthyroid patients, doses within
the range of daily hormonal requirements are ineffective
for weight reduction. Larger doses may produce serious or
even life-threatening manifestations of toxicity, particularly
when given in association with sympathomimetic amines
such as those used for their anorectic effects."
Side Effects:
Side effects are generally associated with overdosage, and
may include headache, irritability, nervousness, sweating,
irregular heartbeat, increased bowel motility, or menstrual
irregularities. Overdosage may also induce shock, and may
aggravate or trigger angina or congestive heart failure.
Chronic overexposure to liothyronine sodium will produce
symptoms normally associated with hyperthyroidism or
the overproduction of natural thyroid hormones in the
body.The occurrence of overexposure-linked side effects is
normally cause to immediately reduce or discontinue
therapy with liothyronine sodium. Acute massive overdose
may be life threatening.
Administration:
When used to treat mild hypothyroidism, the typical
recommended starting dosage is 25 mcg daily. The daily
dosage then may be increased by no more than 25 mcg
every 1 to 2 weeks. The established maintenance dose is
usually 25-75 mcg per day. Once a day administration of
the full daily dose is usually recommended. Although
liothyronine sodium is fast acting, its effects may persist in
the body for several days after discontinuance.
The usual protocol among bodybuilders and athletes
taking liothyronine sodium to accelerate fat loss involves
initiating its use with a dosage of 25 mcg per day. This
dosage may be increased by 25 meg every 4 to 7 days,
usually reaching a maximum of no more than 75 mcg per
day. As in a medical setting, the intent of this slow buildup
is to help the body become adjust to the increasing
thyroid hormone levels, and avoid sudden changes that
may initiate side effects.
Cycles of liothyronine sodium usually last no longer than
6 weeks, and administration of the drug should not be
halted abruptly. Instead, it is discontinued in the same
slow manner in which it was initiated. This usually entails
reducing the dosage by 25 meg every 4 to 7 days. This
tapering is done so that the body has time to readjust its
endogenous hormone production at the conclusion of
therapy, and to avoid the onset of side effects.
Availability:
Liothyronine is an old and widely prescribed medication.
It can be found readily in most areas of the world, and is
sold in a variety of different brand and generic forms.
Counterfeiting is not a large-scale problem. It is important
to note than one should never purchase an injectable
form of this drug. These are generally used as emergency
room products only, with potentially very dangerous side
effects if misused.
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