drtbear1967
Musclechemistry Board Certified Member
There has always been a lot of anecdotal evidence by gym rats saying that the anabolic steroid nandrolone decanoate(Deca) can help alleviate joint point, but is there any science to back this claim up? It turns out that there may in fact be a mechanism that could explain this phenomena. This study shows that nandrolone(via NorAndrostendione/diol) can bind to the aldosterone receptor and amplify its effects in a sodium loaded state. Aldosterone is a mineral corticosteroid that controls mineral and electrolyte uptake into cells. It's essentially the master regulator of the sodium/potassium ratio.
This study showed that adding aldosterone and nandrolone to a sodium loaded state can potentiate the actions of aldosterone and significant decrease in sodium excretion. This means that your body is pumping more sodium into your cells which causes some water retention. If it does this around your joint tissue, you now have water/fund retention by your joints and interstitial tissue which may decrease joint pain and discomfort. This may explain why despite Nandrolone not readily converting to estrogen, it still can cause some water retention that may be beneficial. Some bodybuilders claim Deca is a godsend for your joints, while personally I have never really felt it did much for my joints. Nevertheless, here is a possible mechanism that can explain this very common gym rat occurrence.
This study showed that adding aldosterone and nandrolone to a sodium loaded state can potentiate the actions of aldosterone and significant decrease in sodium excretion. This means that your body is pumping more sodium into your cells which causes some water retention. If it does this around your joint tissue, you now have water/fund retention by your joints and interstitial tissue which may decrease joint pain and discomfort. This may explain why despite Nandrolone not readily converting to estrogen, it still can cause some water retention that may be beneficial. Some bodybuilders claim Deca is a godsend for your joints, while personally I have never really felt it did much for my joints. Nevertheless, here is a possible mechanism that can explain this very common gym rat occurrence.