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Depression and AAS Use / Facts

drtbear1967

Musclechemistry Board Certified Member
What is depression?
Depression is a very complex issue, which doctors still do not fully understand. It is agreed that it can be a genetic trait that can occur even in those with no history of depression at all. Depression is a constant sense of hopelessness and despair. In fact, this sense is so strong, that those who are depressed may find it difficult to study, work, eat, enjoy friends/family, or hobbies in general. Strangely, depression can occur once in your life, or many times over the years.It is one thing to get sad when your team loses a game, but feeling suicidal and locking yourself in the room to cry is another thing altogether. Remember, there is a difference between clinical depression and having a bad day. The main point is that with depression the person will wake up depressed, and be depressed most of the day for at least 2 weeks at a time.If you have some of the following symptoms, and they last more than 2 weeks in a row, you are likely to have clinical depression:
  • Lack energy almost all the time.
  • Almost daily feelings of guilt or worthlessness.
  • Major weight gain or loss.
  • Frequent suicidal thoughts.
  • Diminished interest in activities.
  • Insomnia (lack of sleep) or hypersomnia (too much sleep).
According to the NIMH, major depression affects 7% of the adult US population, and 1 out of 4 adults will experience an episode of major depression during their life. Major depression is often undiagnosed and untreated among the elderly and teens/children, even though it occurs in these demographics quiet often.
Factors that increase the chance of depression


Abuse
:
Past physical, sexual, or emotional abuse can translate into adulthood as depression.

Drugs
:
Certain medications have side effects that cause depression.

Conflict
:Those that have conflicts with family or friends open themselves up for depression, especially if they are genetically vulnerable.
Death
:
Losing a loved one or someone close to you.

Genetics
:It is considered more likely you will have depression if it runs in your family, although, as mentioned previously, it can still occur in those with zero history. Therefore, individual genetics determine the level of vulnerability to clinical depression.

Major events
:Change is good, right? Well, with depression that cliche may not translate because getting a new job, moving, getting married or retiring can throw some people into depression, especially those with poor adaptation ability.

Personal issues
:Being castoff among family or friends is a big issue. Scientific studies have proven that being ostracized (segregated) from a group can lead to physiological reactions, which can be found in cases of major depression. This means that such social pressure can lead to depression in the long run.

Illness
:An athlete who is unable to workout can go into depression. Something similar can happen to individuals with major illnesses, such as cancer, that impair their ability to be active. As a matter of fact, there is a technique in psychological practice that is used to treat depression, which is related to this particular aspect of depression. It consists of getting the depressed patient to be active and practice hobbies that used to be pleasant, sports among them.

Substance abuse
:1 out of every 3 people who abuse substances have depression. If you know someone who does recreational drugs, smokes, or drink alcohol on a daily basis, there is a 30% chance they are in depression. That has to do with the psycho-biological origin of major depression because these substances affect one's system on a biological level.

Hormonal changes in men
A lot of depression symptoms in men are swept under the rug because they are considered "just men being men", or the men are too proud to seek help or even talk about it. Furthermore, men themselves will ignore depression symptoms, even when obvious symptoms arise, and push through the problem more than females will. As a result, the statistics get skewed, where people think only females get depressed, whilst men do as well.

Testosterone's role in depression

Scientists are not completely sure why low testosterone causes depression, but they do know there is a link between the two. When you come off an anabolic steroid cycle, your HPTA (Hypothalamic–pituitary gonadal axis) will not be functioning properly. The reason for this are your pituitary glands, which provide LH to your testes and leydig cells. The pituitary glands will recognize excess hormones and will go dormant during the cycle. This means your body will not be producing testosterone naturally until it can recover, this period is known as post cycle therapy (PCT) and bridge phase. This is the period of time between the moment when your exogenous hormones exit, and you start another steroid cycle. The goal during this phase is to recover your own body's ability to produce testosterone naturally. Many steroid abusers do not take enough time off between steroid cycles, and, as a consequence, their bodies are never able to completely recover. Repeated steroid abuse like will result in permanent HPTA failure, that will cause permanent low testosterone levels and long term depression. To offset this, it is important to run a proper post cycle therapy (PCT) and bridge.

Estrogen's role in depression

Low estrogen levels will cause depression, and high estrogen levels will contribute to spiking prolactin, which can also lead to depression. Men need estrogen to function correctly and there must be a balance. On a steroid cycle, you can expect a rise in estrogen if you run such aromatizing compounds as testosterone, dianabol, deca durabolin, etc. To balance this, you need to run an aromatase inhibitor, like aromasin or arimidex, but it must be run correctly, as running too much will cause estrogen to drop too low.

Diet and lifestyle choices

Diet and lifestyle choices can affect testosterone levels and depression. It is a nasty domino effect that will be triggered by lack of exercise, poor diet, unhealthy sleep, and life stresses. Unfortunately, this is difficult to reverse. People who are depressed tend to be addicted to cigarettes, alcohol, drugs, and other vices, and the brief dopamine surges they get from using them are their only way out of that depression. To put it simply, an unhealthy and unbalanced body has little reason to produce testosterone as nature would not want you to produce offspring.

Depression Causes


Roid Rage
A lot of depression symptoms occur when men come off anabolic steroids. Irritability, anger, drug/alcohol abuse are just some of the examples of symptoms manifesting themselves. Repressing their feelings will result in violent behavior directed at themselves and, unfortunately, others. This is known in the bodybuilding community as "roid rage".There is a lot of humor and joking about roid rage, but it really is no laughing matter. It can land a man in jail, ruin relationships, ruin their jobs, and cause personal physical/mental anguish.Professional wrestler Chris Benoit committed a murder-suicide, and the media automatically blamed steroids for it. However, we know that he also suffered from clinical depression. Did the steroids make his situation worse? Maybe, but it seems like his situation was a disaster waiting to happen, where the steroids may have merely helped speed up the process. But did they really? It was later revealed that Chris Benoit was abusing pain killers and recreational drugs, so the case is not clear at all.In theory, Roid rage impairs impulse control and provokes overreactions. If someone says something to you, there is more chance of you being aggressive, rather than to simply walking away. While this is an example of “men being men”, in reality it's just immaturity. Essentially, if you were a hothead before steroids, then steroids will make you a bigger hothead. If you have any signs of impulsive behavior, and/or depression, that has been characterized above, you are a prime candidate to suffer from major depression and roid rage when using anabolic steroids. Certain individuals, like Benoit, should not be using steroids in the first place – period. Furthermore, all of us probably know someone who shouldn't be using anabolic steroids, but we do nothing about it.

The Bodybuilder life

Many bodybuilders who are obsessed with the lifestyle tend to have physical insecurities, which manifest themselves in mental insecurities. Perhaps when younger they were picked on for being skinny or fat, or maybe they are short in height. It's possible that they have a small 'package' and use bodybuilding as a way to compensate.Bodybuilding is a way out, and it is likely a big reason why these obsessed bodybuilders turn to anabolic steroids - to reach their goals faster and in an exaggerated manner. When steroids are stopped, or an injury takes place and interferes with their ability to make gains, the athlete can fall into depression.

Dopamine, prolactin and sex


Dopamine
Dopamine rules when it comes to our sexual desires and survival needs. It motivates us to do almost everything we do to get rewarded, and all mammals are bestowed this neurotransmitting chemical. Dopamine is behind the desire to have sex or eat a yummy NY style pizza. It also is the pleasure/reward center for gambling, shopping, smoking, and even computer games. You get a bigger blast of dopamine from eating that slice of pizza than you do eating a plate of raw broccoli; therefore, it isn't the pizza that you love, it is that dopamine rush you get when you bite into it.Humans have evolved to make more babies with different partners to create more genetic variety among your offspring, and dopamine is the driving force. Hence, those with higher dopamine will get bored very fast of having sex with the same partner who bores them with the same sexual positions. In regards to sex, they will seek other partners, or desire other fetishes that they may find immoral when dopamine drops back down. Swinging is a perfect example, as the participants will get a rush during the event, but may have regrets after the dopamine has worn off.

Prolactin
I could write an entire book on prolactin, but basically it is a hormone protein, which enables female mammals to produce milk to breastfeed. In males, it will spike when dopamine drops because it has an inverse relationship. High prolactin levels in men will drive down libido and desire for sex.When we have an orgasm, 2 things happen in relation to dopamine and prolactin. Dopamine drops as we get our release, and prolactin will spike for up to two weeks (refractory period). The lack of desire to have sex after orgasm in males is directly linked to this phenomenon. Interestingly, this occurs with any type of dopamine related desire. Have a pizza? Feel better, don't want pizza for a period of time. Down a shot of alcohol? Feel better, don't need a shot for X amount of time. Dopamine literally runs the life of people with major addictions and depression. Many people become a slave to whatever vice can make them feel guilty, ruin jobs/relationships, and put them into a deeper hole with regards to depression.

Dopamine link to steroids

When anabolic steroids are used, they will affect the dopamine neurotransmitter systems. Those with too much dopamine tend to have more anxiety, aggression, addictions, compulsions, sexual fetishes/addictions, and take bigger risks. On the flip side, depression may occur when the roller coaster of coming off steroids occurs and dopamine drops. This leads to seeking of addictions to get a relief from depression, antisocial behavior, low libido/ED (erectile dysfunction), and lack of motivation/ambition. This is why you may notice some guys who use anabolic steroids are in the gym almost everyday, but when they come off steroids they disappear. After cycle without a proper pct, they totally lose their drive. In fact, it is very likely they had low dopamine prior to steroid use, being, therefore, prone to depression as it is. As a result, the steroid abuse (not using pct) sent them on an emotional roller coaster, and without steroids they just cannot find the motivation anymore to get off the couch.

Steroids and Addictions


Trenbolone and androgenic steroids
It is important to note that trenbolone not only will increase dopamine, but it will also increase prolactin. This can negatively affect those prone to aggression and 'roid rage', and most certainly those who are unbalanced prior to steroid use should avoid using trenbolone. Otherwise, they may end up in jail or easily ruin a relationship.In addition, it has been proven in studies that androgenic compounds can activate functions for both dopamine and serotonin release. Serotonin spikes can also influence mood and aggressiveness. So, if you have major aggression issues, androgenic compounds should be avoided.

Addictions

Those prone to addictions will find anabolic steroid use detrimental. Using steroids and spiking dopamine can cause more anxiety and addiction. Furthermore, stopping steroids and having dopamine tank can cause depression linked addictions. Therefore, either way, an addict will become more addicted to their vice of choice.We know that most gamblers lose money, so why do they do it? Because of the dopamine rush they get, it is as simple as that. Almost every gambler out there has a dopamine imbalance of either too much or too little. Until they balance that, they are headed to being broke eventually. Add steroids to the mix, and a gambler will become even more reckless in the casino.

FAQ about Depression


Who is most likely to get depression after steroid cycles?
Those that have existing addictions, and/or have existing depression issues, are almost certain to become more depressed when they come off anabolic steroids. Those that fail to run a post cycle therapy (PCT) and just stop steroids cold turkey without any planning, are much more likely to lose motivation and the power of will to workout. Unfortunately, there are too many athletes who do not bother to workout when they aren't on steroids because they fall into depression from a lack of dopamine and testosterone. The underlining cause of all this is the lack of knowledge to use a proper post cycle therapy to recover natural testosterone levels after a cycle.

My boyfriend is taking/took steroids and now is depressed, what can I do?

This question comes up a lot on forums, and the first course of action you can do is attempt to educate him on why he is going through this. Next, the best advice for him would be to stop taking anabolic steroids because his depression will only become worse. Furthermore, he would need to run a proper post cycle therapy (PCT) by implementing both HCGenerate ES and SARMS. This will help him keep his gains, libido, boost his dopamine and testosterone, and lower his prolactin. Later on, with more maturity, a better frame of mind and a proper plan, he can attempt to take steroids again.

What is the best Post Cycle Therapy (PCT) to guarantee recovery after cycle?

The best post cycle therapy in the world right now is the “Perfect PCT” plan that relies on a 7 week run of multiple compounds to guarantee post-cycle recovery. If you're not using the perfect PCT, you're risking poor recovery and potential permanent HPTA shutdown. HPTA shutdown will cause the dreaded depression symptoms everyone wants to avoid.

Helping avoid depression during PCT


Supplements during PCT
There is a legume called Mucuna Pruriens that actually boosts dopamine, lowers prolactin, and increases testosterone. As a matter of fact, studies showed that it increased testosterone by 27% and dropped prolactin levels by 33%. The secret to boosting dopamine is L-DOPA (levadopa), which is the precursor for the hormone/neurotransmitter dopamine. Hence, after being ingested it converts into dopamine!In addition, there are two minerals, zinc and magnesium, which have been proven to lower prolactin; thus, helping to raise dopamine in the process.

SARMS during PCT

SARMS are another great product to use during post cycle therapy, and also during your bridge.SARMS are Selective Androgen Receptor Modulators. They work by hitting your androgen receptors, but are not as suppressive as anabolic steroids, so they can be used off cycle. Blood work has shown that after using Ostarine (MK-2866) for 4 weeks or less, LH levels dropped only ~10-15%, compared to dropping 95% with anabolic steroids. Therefore, your HPTA will still function, and you can keep your gains and strength easier.Moreover, using Cardarine (GW-501516) is totally safe as it is a PPAR, and it's non hormonal. Cardarine will aid you in keeping your endurance levels up, and it will keep bodyfat levels low.Implementing SARMS during pct and bridge will be an added weapon in maintaining your motivation for the gym.
 
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Depression is real and especially around the holidays we find ourselves more stressed and over extended. Take care of yourselves.
 
Cognitive-behavioral therapy (CBT) combines cognitive therapy, which involves examining how thoughts affect emotions, and behavioral therapy, which involves changing a person’s reactions to challenging situations. CBT is goal-oriented and works best when the patient takes an active role. One aspect of CBT helps a person recognize the automatic thoughts or core beliefs that contribute to negative emotions. The therapist helps the person see that some of these thoughts and beliefs are false or don’t make sense and helps the person change them. Types of automatic thoughts may include focusing on one negative idea (an unkind person) and applying the negative quality to everything (the human race in general); viewing things as “all good” or “all bad”; or applying labels such as “loser,” “no good,” or “worthless.” Types of core beliefs may include, “I have to succeed at everything”; “Everyone has to love me”; “It’s a disaster if things don’t go the way I plan or expect”; or “I can’t change the miserable way I am.”
The behavioral aspect of CBT takes place after a person has a more calm state of mind. The person can then take actions that help him or her move closer to planned goals. For example, if depression has caused someone to withdraw from life, that person may be encouraged to participate in hobbies or spend time with friends. Or a person may be gently coached, under supervision, to confront situations, things or people that cause fear or panic. Through practice, a person learns new, healthier behaviors.
With CBT, the therapist assigns homework. It may include journaling, reviewing notes or tapes of the therapy session, or trying a new approach to an old problem. There may also be exercises to make a person more aware of his or her own thoughts and actions without judging them.
The most important parts of any type of therapy are partnership, communication, goals, collaboration, trust, understanding and action. Successful therapy can help a person change thoughts, beliefs, perceptions, actions and moods for the better.
 
I am on medication.

Trt testosterone 100 mg per week. But I blast more often.

Adderall 20 mg two times a day for adhd. Really helps me focus and stick to one task at time.

Buprenorphine 8 mg once every morning ruptured disc neck and back. Helps with pain but had got addicted to pain killers. Been sobar 10 years.

Lexapro 10 mg every morning. Helps with obsessive compulsive and great for anxiety I have. Can't take xanax or any benzo's like those too much too.

I take no narcotics any more at all. Had surgeries hernia repairs dental work and only take toradol. On hernia surgeries I only was put to sleep no narcotic pain meds even for them to put me under just the liquid diazapam stuff. Was fine ate at sonic right after. Lol!!!

Depression we all get it. My trt has helped but it's more about pushing through. We do good things we feel good we do shitty things we feel shitty. We don't try out best and slack on our part we feel shitty too. It's important to set our standards realistically and meet them. Establish our moral system and live by these values.

I have taken l-dopa and still do but only by chance it's in alot of supplements. If we are continuing to feel depressed alot of anti-depressants are worth a try. They work overtime not over night. They help to balance a chemical neurotransmitter imbalance in our brain and most of our cells. I have put alot of things into my body i have not been afraid to try medicine approach but I don't just trust my Dr. I find out all I can then talk to Dr and this way him and I can speak about best approach.
 
The mind is more powerful than any muscle, I have known some people that have gotten so deep in their own head they couldn't get out. Very sad story.
 
I would also start looking into Essential Oils and their use to cure the mind and body. The medical community is quickly shifting from calling them pseudo medicine to doing actual pubmed studies showing they work. For example, They recently found that injecting high quality lavender essential oil is just as effective than Lorazepam in treating anxiety!

A controlled clinical study was then performed to evaluate the efficacy of silexan, a new oral lavender oil capsule preparation, versus a benzodiazepine. In this study, the efficacy of a 6-week-intake of silexan compared to lorazepam was investigated in adults with GAD. The primary target variable was the change in the Hamilton Anxiety Rating Scale (HAM-A-total score) as an objective measurement of the severity of anxiety between baseline and week 6. The results suggest that silexan effectively ameliorates generalized anxiety comparable to a common benzodiazepine (lorazepam).

In conclusion, our results demonstrate that silexan is as effective as lorazepam in adults with GAD. The safety of silexan was also demonstrated. Since lavender oil showed no sedative effects in our study and has no potential for drug abuse, silexan appears to be an effective and well tolerated alternative to benzodiazepines for amelioration of generalised anxiety.
https://www.ncbi.nlm.nih.gov/pubmed/19962288/

Lavender Essential Oil can be used to treat Mild Anxiety Depressive Disorder (MADD)
Compared to placebo, the patients treated with Silexan had a better over-all clinical outcome and showed more pronounced improvements of impaired daily living skills and health related quality of life. Eructation was the only adverse event with a substantially higher incidence under Silexan. The study thus demonstrates that Silexan is efficacious and safe in the treatment of MADD.
https://www.ncbi.nlm.nih.gov/pubmed/26718792

For those of you whos suffer from RLS, use Lavender Oil as a massage oil on your legs before bed.
[h=4]CONCLUSIONS:[/h]<abstracttext label="CONCLUSIONS" nlmcategory="CONCLUSIONS">Lavender oil massage was effective to improve RLS in hemodialysis patients. It has no adverse effects, is practical and cost-effective. It is suggested to be used along with routine treatment of RLS in hemodialysis patients.</abstracttext>
https://www.ncbi.nlm.nih.gov/pubmed/26835466

Oh, and it can regrow hair, creating new follicles!
The experimental animals were divided into a normal group (N: saline), a vehicle control group (VC: jojoba oil), a positive control group (PC: 3% minoxidil), experimental group 1 (E1: 3% LO), and experimental group 2 (E2: 5% LO). Test compound solutions were topically applied to the backs of the mice (100 μL per application), once per day, 5 times a week, for 4 weeks.
The changes in hair follicle number, dermal thickness, and hair follicle depth were observed in skin tissues stained with hematoxylin and eosin, and the number of mast cells was measured in the dermal and hypodermal layers stained with toluidine blue. PC, E1, and E2 groups showed a significantly increased number of hair follicles, deepened hair follicle depth, and thickened dermal layer, along with a significantly decreased number of mast cells compared to the N group. These results indicated that LO has a marked hair growth-promoting effect, as observed morphologically and histologically. Thus, LO could be practically applied as a hair growth-promoting agent.
https://www.ncbi.nlm.nih.gov/pubmed/27123160
 
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