Area 1255
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Original Article Link --> https://area1255.blogspot.com/2016/11/does-masteron-dht-drostanolone.html
:::Q:::
"Area, does Masteron have an effect on Cortisol? Does it decrease cortisol levels?"
~Dave Q
:::A:::
Research shows that Dihydrotestosterone inhibits the HPTA stress response by cross-activating estrogen-Receptor beta, this causes a decrease in circulating corticosteroids, strong compounds, like Masteron, tend to have direct blocking action on Cortisol, by acting both at the hypothalamus and by acting on beta-endorphin related pathways [!].
So Yes, Masteron absolutely can lower Cortisol levels.
Perhaps not as much as more ''official'' cortisol blockers, but it does to an extent.
***SOURCES***
Horm Behav. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as:
Horm Behav. 2012 Jan; 61(1): 147–155.
Published online 2011 Oct 1. doi: 10.1016/j.yhbeh.2011.09.010
PMCID: PMC3264812
NIHMSID: NIHMS334274
TESTOSTERONE AND SPORT: CURRENT PERSPECTIVES
Drostanolone Propionate : Chemical Database and Readout by PubChem@NIH - National Institutes of Health
J Neurosci. 2006 Feb 1;26(5):1448-56.
The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.
"Area, does Masteron have an effect on Cortisol? Does it decrease cortisol levels?"
~Dave Q
:::A:::
Research shows that Dihydrotestosterone inhibits the HPTA stress response by cross-activating estrogen-Receptor beta, this causes a decrease in circulating corticosteroids, strong compounds, like Masteron, tend to have direct blocking action on Cortisol, by acting both at the hypothalamus and by acting on beta-endorphin related pathways [!].
So Yes, Masteron absolutely can lower Cortisol levels.
Perhaps not as much as more ''official'' cortisol blockers, but it does to an extent.
***SOURCES***
Horm Behav. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as:
Horm Behav. 2012 Jan; 61(1): 147–155.
Published online 2011 Oct 1. doi: 10.1016/j.yhbeh.2011.09.010
PMCID: PMC3264812
NIHMSID: NIHMS334274
TESTOSTERONE AND SPORT: CURRENT PERSPECTIVES
Drostanolone Propionate : Chemical Database and Readout by PubChem@NIH - National Institutes of Health
J Neurosci. 2006 Feb 1;26(5):1448-56.
The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.
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