drtbear1967
Musclechemistry Board Certified Member
Enclomiphene is making its rounds in the bodybuilding scene so I figured I would make a post and drop some knowledge. Enclomiphene is the pure trans, or E isomer of clomiphene AKA clomid. Clomid is a racemic mix of both the Z and E(cis and trans) isomers, and zuclomiphene is the cis isomer. Zuclomiphene was identified as the isomer which causes more of the estrogenic side effects, as well as increases in cholesterol associated with clomid use. Enclomiphene(Androxal) has been approved for treating hypogonadism and the data from the clinical trials was very good. Subjects(baboons) with test levels <170ng/dL given 1.5mg/kg of enclomiphene for 12 days showed increases of test with levels up to 1144ng/dL, higher than subjects given clomid! They also had an 8% reduction in cholesterol. In phase 2 trials, 124 men with low test were given 25mg/d of enclomiphene for 3 months and increased test levels by 220%. They also showed significant increases in LH and FSH. Enclomiphene at 25mg/d increased test levels greater than the standard 5g topical test gels, not to mention an 11.7% increase in sperm vs a decrease of 56.6% in the test gel group. Basically, if you want the chemically pure form of clomid with less side effects, enclomiphene is the choice for treating hypogonadism.
