Fat loss and AAS (Is it real?)
Fat loss is fat burning.. Is water wet? I feel people confuse the concepts with applying restrictions and limitations but separating the process, but let's look at the linear markers, they're one in the same but at different speeds/rates.. Reduction is reduction, let's not get hung up on the structured mindset of acceleration and focus on the the difference with weight-loss and fat loss and overall body composition..
Example - the trade off with building lean tissue while burning fat , yet the scale hardly budges?!?! The things that make you go hmmm..
Over the years there's been a massive debates, and of lately there's been some discussions in many of the panels in regards to AAS and fat loss..Some individuals in the gear world populace are advocating that there's "no such thing", or AAS doesn't burn fat..
So, let's discuss this... (AAS only, no stims or bata's,or GH, JUST AAS and the direct vs indirect mechanisms of action on adipose tissue)
Now, you're gonna hear mix reviews on this.. However, I have seen enough evidence that supports AAS having,creating a environment/platform for fat burning..DIET without a doubt is crucial and the pivotal player..However, there is real science behind fat loss and AAS, but please don't put all your money on it solely as an effective combatant..But nonetheless AAS usage is effective!
As many of us should know "nutrient partitioning" with AAS is one of many parts with the mechanisms of AAS inducing weight-loss, its a cascade of events with nutrients being shuttled in which these effects are taking place with along with healthy eating that will further assist and display with promoting or exacerbating physiological adaptations with weight loss catering to factors that are favoring weight loss or re-gain..
Now In particularly lets talk about what AAS can do, the possibilities and the capabilities that are astonishing the medical research field and everyday people and athletes worldwide..
Truth is; Science knows more about the distant cosmos than they do with hormones, we're merely scratching the service and there's always newer data/clinical studies out-dating an other or contradicting each other..One study my cite this, as an other cites that, just know what how to decipher what you're hearing/reading and research your research..
AAS that are seen/recognized on the high/or moderate androgenic scale will in fact promote/increase lypolysis..Thus andros have a higher binding affinity to AR's (throughout tissue)..
FYI; Androgen receptors are found throughout cellular groups, as well as FAT and muscle cell/groups, now we know that they initiate a response on AR's in muscle cells to promote size/growth.. But what about the same given action or events they will have on other cells and AR's found therein fat cells inducing activity/burning??
Higher/more potent the androgen binds to the androgen receptors, the greater the lipolytic response will be on adipose tissue (brown or white)...
Now, lets also take into great consideration AR upregulation with the presence of androgens, more AR sites throughout targeting tissue..,There's a vast amount of activity in which a complex interplay between activation and inactivation mechanisms and signaling between cell groups, what People need to remember that hormones are "chemical messengers" that rely messages to cells that display specific receptors for each hormone and respond to the signaling..Depending on the compounds and the individuals metabolization ratio the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events.. So, the notion that fat Loss is NOT presence and to mitigate that AAS don't posses any fat loss properties is absurd...AR receptors and adipose tissue influence each other in a bidirectional and reciprocal way, keep in mind that The receptors for androgen are present in adipose tissue and other tissue found throughout the body..Testosterone (androgens/AAS )has been reported to inhibit lipid uptake and lipoprotein lipase activity in adipocytes, and stimulate lipolysis (stimulating fat loss), in part by increasing the number of lipolytic beta-adrenergic receptors. In addition, testosterone inhibits the differentiation of preadipocytes to adipocytes.
So, yes AAS may assist with fat loss, however don't expect miracles and it's advised to have a lower body fat% by diet to expect to see more fat loss effects, but its not crucial..Have your macro's dialed in with your AAS intake, cardio ,and anything is possible, we've seen amazing things happen in this lifestyle..Even a couch potato can see results (whether it's deserving or not is a completely different topic)
There's an abundance of clinical research and peer-reviewed data that strongly supports testosterone (and other AAS) fat reducing actions and its preventative impact on adipocyte generation...As AAS (especially Testosterone) acts both in the breakdown of existing fat tissue and to hinder pre-adipocytes from maturing.
This is where some AAS began you acquire there reputation, or spin a myth (winstrol) at promoting fat loss, and achieve lower body fat,cuts..With this said, there's some truth behind winstrol and cuts, but not directly!
(some take home notes)
lets examine a few things here aside from genetics, diet and cycle length/dosage employed, age of and/or genetic presdispoinistions that may exist as well as VERY unhealthy living habits:
It's true you'll lose adipose tissue by way of AAS usage through protein synthesis as well as Androgen receptors (AR's) that are presently are found throughout cellular groups, as well as FAT adipose tissue and muscle cell/groups, now we know that they initiate a response on AR's in muscle cells to promote size/growth, at the same given time they will have a cascade of effects on other cells and AR's found therein fat cells inducing activity/burning.. shift in metabolism, hormonal induces thermogensis and non AR mediated mechanism and the employment expressed through differentiation of satellite cells? Yes, however beyond anything else here: At the end of the day this all becomes dependent on the individual and how much they diligently value their gains made, and their way of life and commitment to the kitchen and training.."consistency", stay true and work hard.. One can not expect to go in one direction, while living a life style in a completely other direction..
If you're boundless with your actions and usage with AAS and willing to take the plunge and use AAS, than you should expected a course of action to follow suit there after when your commitment is there with living a healthy way of life with mature adult decisions focusing on your diet, the results will be that much greater...AAS usage is one of the most misleading lifestyles that there possibly is, it's extremely contradictive and very misleading..The gold standard idea of gear & fat-loss is decided ultimately on your kitchen habits, but studies and anecdote peer review data states AAS will assist along the processes...It's been proven by way of extensive research, world wide!
There's no short cuts, make the gym/kitchen your church, the blood sweat and tears shall be your prayers, and the results will be your salvation!
Enjoy the read and feel free to talk about it your stand-point..
Vision
__________________________________________________
Below is some studies conducted in fat loss, one in particular stresses the relation with diet and TRT and others just on a placebo and diet...The outcome is astonishing!!
Testosterone Treatment Combined With Diet Reduces Fat, Maintains Muscle
April 5, 2016
By Frances Morin
BOSTON -- April 5, 2016 -- Obese men treated with testosterone in addition to a low-calorie diet show greater reduction in body fat and less loss of muscle mass than men on similar diets who did not receive testosterone, according to a study presented here at the 98th Annual Meeting of the Endocrine Society (ENDO).
“In men successfully losing weight through diet, both lean and fat mass are lost,” said Mark Ng Tang Fui, MBBS, BMedSc, The University of Melbourne, Heidelberg, Australia, on April 3.
“The addition of testosterone prevents the loss of lean mass and shifts weight loss to almost exclusive loss of fat,” he added.
Obesity has been linked to lower testosterone levels, whereas weight loss resulting from calorie restriction is linked to increases in circulating testosterone, noted the researchers. At the same time, weight loss in middle-aged men typically depletes fat and muscle.
Although testosterone treatment has been also shown to reduce fat mass, the effects of combining testosterone treatment with calorie restriction have not been demonstrated.
For the study, the researchers enrolled 100 obese men (body mass index [BMI], >30 kg/m2), aged 18 to 75 years, with low to low-normal serum total testosterone levels (average of 2 consecutive morning fasting levels of <12 nmol/L [<346 ng/dL]).
The men were all placed on a very-low-calorie diet (~600 kcal/day) for 10 weeks, followed by a maintenance period of 46 weeks. They were randomised 1:1 in a blinded fashion to receive intramuscular testosterone 1,000 mg or placebo injections at baseline, week 6, and every 6 weeks thereafter over the 56 weeks of the study.
At the study’s end, weight loss in both groups was similar, ie, an average of 11 kg (24.2 lb; P < .05 vs baseline). However, patients in the testosterone group lost 3 kg (6.6 lb) more body fat than those in the placebo group (P = .05) and lost significantly less lean mass than those in the placebo group (P = .001).
Patients in the testosterone group also lost significantly more visceral adipose tissue at week 56 (P < .05).
“We found that testosterone treatment reduces fat mass in obese men with a low testosterone level, more than the effects of diet alone,” concluded Dr. Fui. “Testosterone treatment also reduces visceral fat, more than the effects of diet alone, and prevents diet-associated loss of lean mass and muscle function.”
“Although these changes are expected to be metabolically favourable, further trials in this population need to determine cardiometabolic and other benefits weighed against potential adverse effects,” Dr. Fui added.
[Presentation title: Effect of Testosterone Therapy Combined With a Very Low Caloric Diet on Fat Mass in Obese Men With a Low to Low-Normal Testosterone Level: A Randomized Controlled Trial. Abstract LB-OR02-1]
____________________________________________
Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss
Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:
Hypogonadism is associated with increased fat mass and reduced muscle mass, which contributes to obesity and health risks, such as cardiovascular disease.Testosterone treatment of hypogonadal men improves muscle mass and reduces fat mass; however, many of these studies are of short duration.Thus, the long-term effects of testosterone on body anthropometry are not known.
WHAT THIS STUDY ADDS:
Long-term testosterone treatment of hypogonadal men, up to 5 years duration, produced marked and significant decrease in body weight, waist circumference and body mass index. Hypogonadism contributes to reduced muscle mass and increased adiposity.Testosterone treatment ameliorates loss of muscle mass and reduces fat accumulation associated with hypogonadism. In this study, we evaluated the long-term effects of normalizing testosterone (T) levels in hypogonadal men on anthropometric parameters. Open-label, single-center, cumulative, prospective registry study of 261 men (32-84 years, mean 59.5 ± 8.4 years, with T levels ***8804;12 nmol L-1 [mean: 7.7 ± 2.1]). Among the 261 men on T treatment, we followed up on 260 men for at least 2 years, 237 for 3 years, 195 for 4 years and 163 for at least 5 years. Subjects received parenteral T undecanoate 1000 mg every 12 weeks after an initial interval of 6 weeks. Body weight (BW), waist circumference (WC) and body mass index (BMI) were measured at baseline and yearly after treatment with T. BW decreased from 100.1 ± 14.0 kg to 92.5 ± 11.2 kg and WC was reduced from 107.7 ± 10.0 cm to 99.0 ± 9.1 cm. BMI declined from 31.7 ± 4.4 m kg-2 to 29.4 ± 3.4 m kg-2. All parameters examined were statistically significant vs. baseline and vs. the previous year over 5 years, indicating a continuous weight loss (WL) over the full observation period. The mean per cent WL was 3.2 ± 0.3% after 1 year, 5.6 ± 0.3%, after 2 years, 7.5 ± 0.3% after 3 years, 9.1 ± 0.3% after 4 years and 10.5 ± 0.4% after 5 years. The data obtained from this uncontrolled, observational, registry study suggest that raising serum T to normal physiological levels in hypogonadal men produces consistent loss in BW, WC and BMI. These marked improvements were progressive over the 5 years of the study.
Fat loss is fat burning.. Is water wet? I feel people confuse the concepts with applying restrictions and limitations but separating the process, but let's look at the linear markers, they're one in the same but at different speeds/rates.. Reduction is reduction, let's not get hung up on the structured mindset of acceleration and focus on the the difference with weight-loss and fat loss and overall body composition..
Example - the trade off with building lean tissue while burning fat , yet the scale hardly budges?!?! The things that make you go hmmm..
Over the years there's been a massive debates, and of lately there's been some discussions in many of the panels in regards to AAS and fat loss..Some individuals in the gear world populace are advocating that there's "no such thing", or AAS doesn't burn fat..
So, let's discuss this... (AAS only, no stims or bata's,or GH, JUST AAS and the direct vs indirect mechanisms of action on adipose tissue)
Now, you're gonna hear mix reviews on this.. However, I have seen enough evidence that supports AAS having,creating a environment/platform for fat burning..DIET without a doubt is crucial and the pivotal player..However, there is real science behind fat loss and AAS, but please don't put all your money on it solely as an effective combatant..But nonetheless AAS usage is effective!
As many of us should know "nutrient partitioning" with AAS is one of many parts with the mechanisms of AAS inducing weight-loss, its a cascade of events with nutrients being shuttled in which these effects are taking place with along with healthy eating that will further assist and display with promoting or exacerbating physiological adaptations with weight loss catering to factors that are favoring weight loss or re-gain..
Now In particularly lets talk about what AAS can do, the possibilities and the capabilities that are astonishing the medical research field and everyday people and athletes worldwide..
Truth is; Science knows more about the distant cosmos than they do with hormones, we're merely scratching the service and there's always newer data/clinical studies out-dating an other or contradicting each other..One study my cite this, as an other cites that, just know what how to decipher what you're hearing/reading and research your research..
AAS that are seen/recognized on the high/or moderate androgenic scale will in fact promote/increase lypolysis..Thus andros have a higher binding affinity to AR's (throughout tissue)..
FYI; Androgen receptors are found throughout cellular groups, as well as FAT and muscle cell/groups, now we know that they initiate a response on AR's in muscle cells to promote size/growth.. But what about the same given action or events they will have on other cells and AR's found therein fat cells inducing activity/burning??
Higher/more potent the androgen binds to the androgen receptors, the greater the lipolytic response will be on adipose tissue (brown or white)...
Now, lets also take into great consideration AR upregulation with the presence of androgens, more AR sites throughout targeting tissue..,There's a vast amount of activity in which a complex interplay between activation and inactivation mechanisms and signaling between cell groups, what People need to remember that hormones are "chemical messengers" that rely messages to cells that display specific receptors for each hormone and respond to the signaling..Depending on the compounds and the individuals metabolization ratio the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events.. So, the notion that fat Loss is NOT presence and to mitigate that AAS don't posses any fat loss properties is absurd...AR receptors and adipose tissue influence each other in a bidirectional and reciprocal way, keep in mind that The receptors for androgen are present in adipose tissue and other tissue found throughout the body..Testosterone (androgens/AAS )has been reported to inhibit lipid uptake and lipoprotein lipase activity in adipocytes, and stimulate lipolysis (stimulating fat loss), in part by increasing the number of lipolytic beta-adrenergic receptors. In addition, testosterone inhibits the differentiation of preadipocytes to adipocytes.
So, yes AAS may assist with fat loss, however don't expect miracles and it's advised to have a lower body fat% by diet to expect to see more fat loss effects, but its not crucial..Have your macro's dialed in with your AAS intake, cardio ,and anything is possible, we've seen amazing things happen in this lifestyle..Even a couch potato can see results (whether it's deserving or not is a completely different topic)
There's an abundance of clinical research and peer-reviewed data that strongly supports testosterone (and other AAS) fat reducing actions and its preventative impact on adipocyte generation...As AAS (especially Testosterone) acts both in the breakdown of existing fat tissue and to hinder pre-adipocytes from maturing.
This is where some AAS began you acquire there reputation, or spin a myth (winstrol) at promoting fat loss, and achieve lower body fat,cuts..With this said, there's some truth behind winstrol and cuts, but not directly!
(some take home notes)
lets examine a few things here aside from genetics, diet and cycle length/dosage employed, age of and/or genetic presdispoinistions that may exist as well as VERY unhealthy living habits:
It's true you'll lose adipose tissue by way of AAS usage through protein synthesis as well as Androgen receptors (AR's) that are presently are found throughout cellular groups, as well as FAT adipose tissue and muscle cell/groups, now we know that they initiate a response on AR's in muscle cells to promote size/growth, at the same given time they will have a cascade of effects on other cells and AR's found therein fat cells inducing activity/burning.. shift in metabolism, hormonal induces thermogensis and non AR mediated mechanism and the employment expressed through differentiation of satellite cells? Yes, however beyond anything else here: At the end of the day this all becomes dependent on the individual and how much they diligently value their gains made, and their way of life and commitment to the kitchen and training.."consistency", stay true and work hard.. One can not expect to go in one direction, while living a life style in a completely other direction..
If you're boundless with your actions and usage with AAS and willing to take the plunge and use AAS, than you should expected a course of action to follow suit there after when your commitment is there with living a healthy way of life with mature adult decisions focusing on your diet, the results will be that much greater...AAS usage is one of the most misleading lifestyles that there possibly is, it's extremely contradictive and very misleading..The gold standard idea of gear & fat-loss is decided ultimately on your kitchen habits, but studies and anecdote peer review data states AAS will assist along the processes...It's been proven by way of extensive research, world wide!
There's no short cuts, make the gym/kitchen your church, the blood sweat and tears shall be your prayers, and the results will be your salvation!
Enjoy the read and feel free to talk about it your stand-point..
Vision
__________________________________________________
Below is some studies conducted in fat loss, one in particular stresses the relation with diet and TRT and others just on a placebo and diet...The outcome is astonishing!!
Testosterone Treatment Combined With Diet Reduces Fat, Maintains Muscle
April 5, 2016
By Frances Morin
BOSTON -- April 5, 2016 -- Obese men treated with testosterone in addition to a low-calorie diet show greater reduction in body fat and less loss of muscle mass than men on similar diets who did not receive testosterone, according to a study presented here at the 98th Annual Meeting of the Endocrine Society (ENDO).
“In men successfully losing weight through diet, both lean and fat mass are lost,” said Mark Ng Tang Fui, MBBS, BMedSc, The University of Melbourne, Heidelberg, Australia, on April 3.
“The addition of testosterone prevents the loss of lean mass and shifts weight loss to almost exclusive loss of fat,” he added.
Obesity has been linked to lower testosterone levels, whereas weight loss resulting from calorie restriction is linked to increases in circulating testosterone, noted the researchers. At the same time, weight loss in middle-aged men typically depletes fat and muscle.
Although testosterone treatment has been also shown to reduce fat mass, the effects of combining testosterone treatment with calorie restriction have not been demonstrated.
For the study, the researchers enrolled 100 obese men (body mass index [BMI], >30 kg/m2), aged 18 to 75 years, with low to low-normal serum total testosterone levels (average of 2 consecutive morning fasting levels of <12 nmol/L [<346 ng/dL]).
The men were all placed on a very-low-calorie diet (~600 kcal/day) for 10 weeks, followed by a maintenance period of 46 weeks. They were randomised 1:1 in a blinded fashion to receive intramuscular testosterone 1,000 mg or placebo injections at baseline, week 6, and every 6 weeks thereafter over the 56 weeks of the study.
At the study’s end, weight loss in both groups was similar, ie, an average of 11 kg (24.2 lb; P < .05 vs baseline). However, patients in the testosterone group lost 3 kg (6.6 lb) more body fat than those in the placebo group (P = .05) and lost significantly less lean mass than those in the placebo group (P = .001).
Patients in the testosterone group also lost significantly more visceral adipose tissue at week 56 (P < .05).
“We found that testosterone treatment reduces fat mass in obese men with a low testosterone level, more than the effects of diet alone,” concluded Dr. Fui. “Testosterone treatment also reduces visceral fat, more than the effects of diet alone, and prevents diet-associated loss of lean mass and muscle function.”
“Although these changes are expected to be metabolically favourable, further trials in this population need to determine cardiometabolic and other benefits weighed against potential adverse effects,” Dr. Fui added.
[Presentation title: Effect of Testosterone Therapy Combined With a Very Low Caloric Diet on Fat Mass in Obese Men With a Low to Low-Normal Testosterone Level: A Randomized Controlled Trial. Abstract LB-OR02-1]
____________________________________________
Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss
Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:
Hypogonadism is associated with increased fat mass and reduced muscle mass, which contributes to obesity and health risks, such as cardiovascular disease.Testosterone treatment of hypogonadal men improves muscle mass and reduces fat mass; however, many of these studies are of short duration.Thus, the long-term effects of testosterone on body anthropometry are not known.
WHAT THIS STUDY ADDS:
Long-term testosterone treatment of hypogonadal men, up to 5 years duration, produced marked and significant decrease in body weight, waist circumference and body mass index. Hypogonadism contributes to reduced muscle mass and increased adiposity.Testosterone treatment ameliorates loss of muscle mass and reduces fat accumulation associated with hypogonadism. In this study, we evaluated the long-term effects of normalizing testosterone (T) levels in hypogonadal men on anthropometric parameters. Open-label, single-center, cumulative, prospective registry study of 261 men (32-84 years, mean 59.5 ± 8.4 years, with T levels ***8804;12 nmol L-1 [mean: 7.7 ± 2.1]). Among the 261 men on T treatment, we followed up on 260 men for at least 2 years, 237 for 3 years, 195 for 4 years and 163 for at least 5 years. Subjects received parenteral T undecanoate 1000 mg every 12 weeks after an initial interval of 6 weeks. Body weight (BW), waist circumference (WC) and body mass index (BMI) were measured at baseline and yearly after treatment with T. BW decreased from 100.1 ± 14.0 kg to 92.5 ± 11.2 kg and WC was reduced from 107.7 ± 10.0 cm to 99.0 ± 9.1 cm. BMI declined from 31.7 ± 4.4 m kg-2 to 29.4 ± 3.4 m kg-2. All parameters examined were statistically significant vs. baseline and vs. the previous year over 5 years, indicating a continuous weight loss (WL) over the full observation period. The mean per cent WL was 3.2 ± 0.3% after 1 year, 5.6 ± 0.3%, after 2 years, 7.5 ± 0.3% after 3 years, 9.1 ± 0.3% after 4 years and 10.5 ± 0.4% after 5 years. The data obtained from this uncontrolled, observational, registry study suggest that raising serum T to normal physiological levels in hypogonadal men produces consistent loss in BW, WC and BMI. These marked improvements were progressive over the 5 years of the study.
