Fundamental understanding of drug absorption from a parenteral oil depot.

[Dean Destructo]

Oil depots are parenteral drug formulations meant for sustained release of lipophilic compounds. Until now, a comprehensive understanding of the mechanism of drug absorption from oil depots is lacking. The aim of this paper was to fill this gap. A clinical study with healthy volunteers was conducted. An oil depot with nandrolone decanoate and benzyl alcohol was subcutaneously administered in the upper arm of female volunteers.

Pharmacokinetic profiles of both substances were related to each other and to literature data. Benzyl alcohol absorbs much more rapidly than nandrolone. In detail, it appears that benzyl alcohol enters the central compartment directly, while nandrolone decanoate is recovered in serum after a lag time. This lag time is also seen in literature data, although not reported explicitly. The absorption of nandrolone is enhanced by the presence of benzyl alcohol. This is most likely an effect of altered oil viscosity and partition coefficient between the oil and aqueous phase. The absorption rate constant of compounds is found to be related to the logP of the solubilized prodrug.

The absorption rate is however not only determined by the physico-chemical properties of the formulation but also by the tissue properties. Here, it is argued that lymphatic flow must be considered as a relevant parameter.

 

[Presser]

Oil depots are parenteral drug formulations meant for sustained release of lipophilic compounds. Until now, a comprehensive understanding of the mechanism of drug absorption from oil depots is lacking. The aim of this paper was to fill this gap. A clinical study with healthy volunteers was conducted. An oil depot with nandrolone decanoate and benzyl alcohol was subcutaneously administered in the upper arm of female volunteers.

Pharmacokinetic profiles of both substances were related to each other and to literature data. Benzyl alcohol absorbs much more rapidly than nandrolone. In detail, it appears that benzyl alcohol enters the central compartment directly, while nandrolone decanoate is recovered in serum after a lag time. This lag time is also seen in literature data, although not reported explicitly. The absorption of nandrolone is enhanced by the presence of benzyl alcohol. This is most likely an effect of altered oil viscosity and partition coefficient between the oil and aqueous phase. The absorption rate constant of compounds is found to be related to the logP of the solubilized prodrug.

The absorption rate is however not only determined by the physico-chemical properties of the formulation but also by the tissue properties. Here, it is argued that lymphatic flow must be considered as a relevant parameter.

Good post, but what oil was used, or am i missing somehting here lol, and wouldnt the viscosity of the oil also come into play with absoption along with tissue and benzly alcohol

im sort of lost man, help me out here

 

[Dnindustry]

I think this is something that needs to be better discussed. I am no newbie, but during my last vacation I realized I had shots in my glutes that never dissipated. Just a heads up to cycle locations.

 

[Mountain_Man]

Bery good info

 

[Presser]

I think this is something that needs to be better discussed. I am no newbie, but during my last vacation I realized I had shots in my glutes that never dissipated. Just a heads up to cycle locations.

how do u mean?

 

[jimbosmith316]

Why would it not dissipate?

 

[Presser]

Yeah im lost on the dissipation thing to

 

[Dean Destructo]

Most likely what he is experiencing is scar tissue replacing the oil depot as it dissipates. I could be wrong though, although I do know it happens to me. Scar tissue footbal
Yes the oil choice would change the absorption. Basically the lower the oil viscosity the faster the absorption, to a point.

Oil based hormones start absorbing almost immediately in most cases, especially Deca. Initial then sustained. That is why it is recommend to start HCG with first shot.