drtbear1967
Musclechemistry Board Certified Member
Drug Affinity Complex(DAC) is a delivery technology developed by ConjuChem in order to protect peptides from rapid degrading and metabolism by the kidneys. A peptide is "chopped" up by enzymes called peptidases, usually very rapidly.
By attaching the synthetic DAC portion to the peptide, it is able to extend the half life from several minutes up to 7 days. If you look at the structure here, you'll see the DAC includes a "linker" molecule and a maleimide molecule which binds to albumin, a protein found in your blood. Covalent attachment to albumin can block both cleavage by peptidases and various mechanisms of clearance of a variety of peptides. Once in the body, the DAC moiety increases bioavailability, as well. So to sum up: DAC can increase the half life of many peptides like CJC-1295 by decreasing the activity of peptidases. It also increases bioavailability and maintains biological activity. I recommend going with this option over certain peptides without DAC so you can enjoy the benefits of the peptide without injecting multiple times a day. <!-- /react-text -->
By attaching the synthetic DAC portion to the peptide, it is able to extend the half life from several minutes up to 7 days. If you look at the structure here, you'll see the DAC includes a "linker" molecule and a maleimide molecule which binds to albumin, a protein found in your blood. Covalent attachment to albumin can block both cleavage by peptidases and various mechanisms of clearance of a variety of peptides. Once in the body, the DAC moiety increases bioavailability, as well. So to sum up: DAC can increase the half life of many peptides like CJC-1295 by decreasing the activity of peptidases. It also increases bioavailability and maintains biological activity. I recommend going with this option over certain peptides without DAC so you can enjoy the benefits of the peptide without injecting multiple times a day. <!-- /react-text -->
