HGH FRAGMENT 176-191
The HGH Fragment or HGH Frag is a modified form of amino acids 176-191 at the C-terminal region of growth hormone.
Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural hGH regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis and inhibits lipogenesis both in laboratory testing and in animals and humans. The HGH fragment does not appear to affect appetite.
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the HGH frag released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), HGH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted hGH effect.
The (HGH fragment 176-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.
At a dosage of 500mcg the (HGH fragment 176-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially stubborn adipose body fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its Human Growth Hormone counterpart.(Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).
Not only does the (HGH fragment 176-191) not interfere with the bodys natural insulin regulation as Human Growth Hormone can, the (HGH fragment 176-191) does not result in cellular proliferation as Human Growth Hormone does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 176-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 176-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993).
What I have gathered is you want to take this peptide on an empty stomach because HGH Frag 176 will mobilize fatty acids. IF you are trying to lose fat, you do not want insulin to be active while GH is active or else you won't lose much fat. In addition you want to make use of the newly mobilized fatty acids so cardio/activity is beneficial. HGH Frag 176-191 is the lipolytic/anti-lipogenic domain of intact hGH. the fragment with the amino acid sequence (176-191) is 56% more bioactive then the fragment with the amino acid sequence (177-191).
First you need to separate GH's lipolytic effect from its other effects.
When you do this you will see that lipolysis does not happen right away. It takes a specific amount of time before it starts.
Second there is a limit to how much lipolysis will be created with GH. That means a little is all you need and for that unit of time more will be no more effective.
Third there are other things that can be used in conjunction w/ GH to increase lipolysis beyond the GH effect threshold.
So that leaves you with timing. When lipolysis is occurring you want to be in fatloss mode. That means no surplus energy and it means doing things to oxidize the newly liberated fatty acids.
Often people are eating and have increased insulin levels by the time lipolysis is in full swing. That for the most part negates fatloss.
Then you need to understand how long lipolysis will last.
So all of this becomes part of a protocol. You don't just expect something to work w/o the proper environment. You can achieve the lipolysis threshold induced by GH w/ synthetic GH, GHRH/GHRP or GH Frag 176-191.
You should understand GH Frag 176-191 and use it properly. Proper use would be on fast day or days where you fast half the day.
A reconstituted vial degrades fairly quickly and so a whole vial should be used w/in a few days.
If you dose 1mg for the day the way to make it work is to dose 200mcgs every few hours five times during the entire day.
It is best if that day is fairly fasted and if you do eat a meal keep the blood glucose response to the meal contained and do not dose around that meal (or it will be wasted).
Note, that you will not waste away muscle in a fasted state and empty stomach cardio will not eat up muscle. The release of fatty acids or lipolysis is an anti-catabolic event. It is why GH in part is anti-catabolic.
Awaken in the morning and do empty stomach cardio after waiting for the GH induced lipolysis to be in full swing (from say previous GHRH/GHRP administration) and you will be able to effect fatloss and not worry about muscle loss.
The HGH Fragment or HGH Frag is a modified form of amino acids 176-191 at the C-terminal region of growth hormone.
Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural hGH regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis and inhibits lipogenesis both in laboratory testing and in animals and humans. The HGH fragment does not appear to affect appetite.
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the HGH frag released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), HGH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted hGH effect.
The (HGH fragment 176-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.
At a dosage of 500mcg the (HGH fragment 176-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially stubborn adipose body fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its Human Growth Hormone counterpart.(Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).
Not only does the (HGH fragment 176-191) not interfere with the bodys natural insulin regulation as Human Growth Hormone can, the (HGH fragment 176-191) does not result in cellular proliferation as Human Growth Hormone does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 176-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 176-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993).
What I have gathered is you want to take this peptide on an empty stomach because HGH Frag 176 will mobilize fatty acids. IF you are trying to lose fat, you do not want insulin to be active while GH is active or else you won't lose much fat. In addition you want to make use of the newly mobilized fatty acids so cardio/activity is beneficial. HGH Frag 176-191 is the lipolytic/anti-lipogenic domain of intact hGH. the fragment with the amino acid sequence (176-191) is 56% more bioactive then the fragment with the amino acid sequence (177-191).
First you need to separate GH's lipolytic effect from its other effects.
When you do this you will see that lipolysis does not happen right away. It takes a specific amount of time before it starts.
Second there is a limit to how much lipolysis will be created with GH. That means a little is all you need and for that unit of time more will be no more effective.
Third there are other things that can be used in conjunction w/ GH to increase lipolysis beyond the GH effect threshold.
So that leaves you with timing. When lipolysis is occurring you want to be in fatloss mode. That means no surplus energy and it means doing things to oxidize the newly liberated fatty acids.
Often people are eating and have increased insulin levels by the time lipolysis is in full swing. That for the most part negates fatloss.
Then you need to understand how long lipolysis will last.
So all of this becomes part of a protocol. You don't just expect something to work w/o the proper environment. You can achieve the lipolysis threshold induced by GH w/ synthetic GH, GHRH/GHRP or GH Frag 176-191.
You should understand GH Frag 176-191 and use it properly. Proper use would be on fast day or days where you fast half the day.
A reconstituted vial degrades fairly quickly and so a whole vial should be used w/in a few days.
If you dose 1mg for the day the way to make it work is to dose 200mcgs every few hours five times during the entire day.
It is best if that day is fairly fasted and if you do eat a meal keep the blood glucose response to the meal contained and do not dose around that meal (or it will be wasted).
Note, that you will not waste away muscle in a fasted state and empty stomach cardio will not eat up muscle. The release of fatty acids or lipolysis is an anti-catabolic event. It is why GH in part is anti-catabolic.
Awaken in the morning and do empty stomach cardio after waiting for the GH induced lipolysis to be in full swing (from say previous GHRH/GHRP administration) and you will be able to effect fatloss and not worry about muscle loss.
