drtbear1967
Musclechemistry Board Certified Member
theguerillachemist
There is a lot of misinformation online and this is one that I come across all the time: Huperzine A as a somatostatin(a protein that tells he brain to stop GH secretion)inhibitor. Many boards suggest to take huperzine A with GHRPs and MK-677. I’m not sure where this started but it’s on almost every forum with absolutely ZERO substantiation.
While yes, huperzine A is an acetylcholinesterase inhibitor I have not found a single paper suggesting it can inhibit somatostatin. There is a paper showing pyridostigmine, an acetylcholinesterase inhibitor can significantly potentiate the GH pulse released by GHPRs, it’s chemical structure is completely different from huperzine A and one should not expect huperzine to work the same way. Another example of this is the Benadryl can help with beta-2 adrenergic receptor downregulation while taking clen. It doesn’t, but another antihistamine, ketotifen does. My point is just bc 2 molecules have the same primary action, doesn’t mean it can have the same ancillary effects. Many factors like pharmacokinetics have to be taken into account. Food for thought.
There is a lot of misinformation online and this is one that I come across all the time: Huperzine A as a somatostatin(a protein that tells he brain to stop GH secretion)inhibitor. Many boards suggest to take huperzine A with GHRPs and MK-677. I’m not sure where this started but it’s on almost every forum with absolutely ZERO substantiation.
While yes, huperzine A is an acetylcholinesterase inhibitor I have not found a single paper suggesting it can inhibit somatostatin. There is a paper showing pyridostigmine, an acetylcholinesterase inhibitor can significantly potentiate the GH pulse released by GHPRs, it’s chemical structure is completely different from huperzine A and one should not expect huperzine to work the same way. Another example of this is the Benadryl can help with beta-2 adrenergic receptor downregulation while taking clen. It doesn’t, but another antihistamine, ketotifen does. My point is just bc 2 molecules have the same primary action, doesn’t mean it can have the same ancillary effects. Many factors like pharmacokinetics have to be taken into account. Food for thought.
