It is systemic , although more attaches to the nearest area it was applied as MM pointed out, but the argument that it doesn't matter where u apply it'll still help all body parts is due to it being systemic .
Personally I think it works as a specific site enhancer as I've used it for years on end and tried every which way. I have settled into applying it to my abs SQ about 75% of the time and feel as though it works best for staying lean with SQ applications and builds muscle best applying to muscles.