IGF vs HGH

[drtbear1967]

Great information from Presser.

If you had to chose between IGF and HGH for the purposes of bodybuilding and overall health and longevity, then IGF wins hands down no contest! is there a place for HGH along side IGF, yes there is if you can afford to run both!

Growth factors are proteins that bind to receptors on the cell surface, with the primary result of activating cellular proliferation and/or differentiation. Many growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type.


Cytokines are a class of signaling proteins that are used extensively in cellular communication, immune function and embryogenesis. Cytokines are produced by a variety of hematopoietic and non-hematopoietic cell types and can exert autocrine, paracrine and endocrine effects as do the hormones. They are, therefore, more correctly related to hormones than to growth factors in their overall functions. However, many cytokines also exhibit growth factor activity so they are discussed here as well as in the Peptide Hormones page.The lists in the following Tables as well as the descriptions of several factors are not intended to be comprehensive nor complete but a look at some of the more commonly known factors and their principal activities.
Growth Factors

[TABLE="class: cms_table"]
<tbody>[TR]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Factor[/TD]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Principal Source[/TD]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Primary Activity[/TD]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Comments[/TD]
[/TR]
[TR]
[TD="align: center"]PDGF[/TD]
[TD]platelets, endothelial cells, placenta[/TD]
[TD]promotes proliferation of connective tissue, glial and smooth muscle cells[/TD]
[TD]represents a family of four peptides encoded by four distinct genes: A, B, C, and D; these four peptides form either homo- or heterodimers such that five distinct biologically active PDGF isoforms (AA, AB, BB, CC, DD) result[/TD]
[/TR]
[TR]
[TD="align: center"]EGF[/TD]
[TD]submaxillary gland, Brunners gland[/TD]
[TD]promotes proliferation of mesenchymal, glial and epithelial cells[/TD]
[TD]represents the founding member of the EGF-family of proteins that includes, but is not limited to, transforming growth factor-α (TGF-α), amphiregulin, and the neuregulins (neuregulin-1, -2, -3, and -4)[/TD]
[/TR]
[TR]
[TD="align: center"]TGF-α[/TD]
[TD]macrophages, keratinocytes, hypothalamic astrocytes; commonly expressed by transformed cells[/TD]
[TD]important for normal wound healing, cellular proliferation, female reproductive maturation, embryogenesis[/TD]
[TD]is a member of the EGF-family of proteins; functions by binding to the EGF receptor[/TD]
[/TR]
[TR]
[TD="align: center"]FGF[/TD]
[TD]wide range of cells; protein is associated with the ECM[/TD]
[TD]promotes proliferation of many cells; inhibits some stem cells; induces mesoderm to form in early embryos[/TD]
[TD]at least 18 family members, 5 distinct receptors[/TD]
[/TR]
[TR]
[TD="align: center"]NGF[/TD]
[TD]mast cells, eosinophils, bone marrow stromal cells, keratinocytes[/TD]
[TD]promotes neurite outgrowth and neural cell survival[/TD]
[TD]member of a family of proteins termed neurotrophins that promote proliferation and survival of neurons; neurotrophin receptors are a class of related proteins first identified as proto-oncogenes: TrkA ("trackA"), TrkB, TrkC[/TD]
[/TR]
[TR]
[TD="align: center"]Erythropoietin[/TD]
[TD="align: center"]kidney[/TD]
[TD]promotes proliferation and differentiation of erythrocytes[/TD]
[TD][/TD]
[/TR]
[TR]
[TD="align: center"]TGF-β[/TD]
[TD]activated Th1 cells (T-helper) and natural killer (NK) cells[/TD]
[TD]anti-inflammatory (suppresses cytokine production and class II MHC expression), promotes wound healing, inhibits macrophage and lymphocyte proliferation[/TD]
[TD]at least 100 different family members[/TD]
[/TR]
[TR]
[TD="align: center"]IGF-1[/TD]
[TD="align: center"]primarily liver[/TD]
[TD]promotes proliferation of many cell types[/TD]
[TD]related to IGF-2 and proinsulin, also called somatomedin C[/TD]
[/TR]
[TR]
[TD="align: center"]IGF-2[/TD]
[TD="align: center"]variety of cells[/TD]
[TD]promotes proliferation of many cell types primarily of fetal origin[/TD]
[TD]related to IGF-1 and proinsulin[/TD]
[/TR]
</tbody>[/TABLE]

Last edited by Presser; 08-05-2016 at 03:14 PM.​

 

[Macho313]

Great information from Presser.

If you had to chose between IGF and HGH for the purposes of bodybuilding and overall health and longevity, then IGF wins hands down no contest! is there a place for HGH along side IGF, yes there is if you can afford to run both!

Growth factors are proteins that bind to receptors on the cell surface, with the primary result of activating cellular proliferation and/or differentiation. Many growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type.


Cytokines are a class of signaling proteins that are used extensively in cellular communication, immune function and embryogenesis. Cytokines are produced by a variety of hematopoietic and non-hematopoietic cell types and can exert autocrine, paracrine and endocrine effects as do the hormones. They are, therefore, more correctly related to hormones than to growth factors in their overall functions. However, many cytokines also exhibit growth factor activity so they are discussed here as well as in the Peptide Hormones page.The lists in the following Tables as well as the descriptions of several factors are not intended to be comprehensive nor complete but a look at some of the more commonly known factors and their principal activities.
Growth Factors

[TABLE="class: cms_table"]
<tbody>[TR]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Factor[/TD]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Principal Source[/TD]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Primary Activity[/TD]
[TD="class: cms_table_tableheads, bgcolor: #CCCCCC, align: center"]Comments[/TD]
[/TR]
[TR]
[TD="align: center"]PDGF[/TD]
[TD]platelets, endothelial cells, placenta[/TD]
[TD]promotes proliferation of connective tissue, glial and smooth muscle cells[/TD]
[TD]represents a family of four peptides encoded by four distinct genes: A, B, C, and D; these four peptides form either homo- or heterodimers such that five distinct biologically active PDGF isoforms (AA, AB, BB, CC, DD) result[/TD]
[/TR]
[TR]
[TD="align: center"]EGF[/TD]
[TD]submaxillary gland, Brunners gland[/TD]
[TD]promotes proliferation of mesenchymal, glial and epithelial cells[/TD]
[TD]represents the founding member of the EGF-family of proteins that includes, but is not limited to, transforming growth factor-α (TGF-α), amphiregulin, and the neuregulins (neuregulin-1, -2, -3, and -4)[/TD]
[/TR]
[TR]
[TD="align: center"]TGF-α[/TD]
[TD]macrophages, keratinocytes, hypothalamic astrocytes; commonly expressed by transformed cells[/TD]
[TD]important for normal wound healing, cellular proliferation, female reproductive maturation, embryogenesis[/TD]
[TD]is a member of the EGF-family of proteins; functions by binding to the EGF receptor[/TD]
[/TR]
[TR]
[TD="align: center"]FGF[/TD]
[TD]wide range of cells; protein is associated with the ECM[/TD]
[TD]promotes proliferation of many cells; inhibits some stem cells; induces mesoderm to form in early embryos[/TD]
[TD]at least 18 family members, 5 distinct receptors[/TD]
[/TR]
[TR]
[TD="align: center"]NGF[/TD]
[TD]mast cells, eosinophils, bone marrow stromal cells, keratinocytes[/TD]
[TD]promotes neurite outgrowth and neural cell survival[/TD]
[TD]member of a family of proteins termed neurotrophins that promote proliferation and survival of neurons; neurotrophin receptors are a class of related proteins first identified as proto-oncogenes: TrkA ("trackA"), TrkB, TrkC[/TD]
[/TR]
[TR]
[TD="align: center"]Erythropoietin[/TD]
[TD="align: center"]kidney[/TD]
[TD]promotes proliferation and differentiation of erythrocytes[/TD]
[TD][/TD]
[/TR]
[TR]
[TD="align: center"]TGF-β[/TD]
[TD]activated Th1 cells (T-helper) and natural killer (NK) cells[/TD]
[TD]anti-inflammatory (suppresses cytokine production and class II MHC expression), promotes wound healing, inhibits macrophage and lymphocyte proliferation[/TD]
[TD]at least 100 different family members[/TD]
[/TR]
[TR]
[TD="align: center"]IGF-1[/TD]
[TD="align: center"]primarily liver[/TD]
[TD]promotes proliferation of many cell types[/TD]
[TD]related to IGF-2 and proinsulin, also called somatomedin C[/TD]
[/TR]
[TR]
[TD="align: center"]IGF-2[/TD]
[TD="align: center"]variety of cells[/TD]
[TD]promotes proliferation of many cell types primarily of fetal origin[/TD]
[TD]related to IGF-1 and proinsulin[/TD]
[/TR]
</tbody>[/TABLE]

Last edited by Presser; 08-05-2016 at 03:14 PM.​

Is igf causes somamodien, what peptide is there that stops the release of somamodien? I have read somewhere before that there is one out there I just cannot remember which one it is if you could enlighten me I would greatly appreciate it brother, but as far as everything else goes presser is definitely right. Considering the whole purpose of taking HGH is to raise your igf levels..

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[drtbear1967]

Not sure if this could be what you are thinking or not.

[h=3]Cellular effects of C-peptide[edit][/h]C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca[SUP]2+[/SUP]-dependent intracellular signaling pathways such as MAPK, PLCγ, and PKC, leading to upregulation of a range of transcription factors as well as eNOS and Na+K+ATPase activities.[SUP][3][/SUP] The latter two enzymes are known to have reduced activities in patients with type I diabetes and have been implicated in the development of long-term complications of type I diabetes such as peripheral and autonomic neuropathy.
In vivo studies in animal models of type 1 diabetes have established that C-peptide administration results in significant improvements in nerve and kidney function. Thus, in animals with early signs of diabetes-induced neuropathy, C peptide treatment in replacement dosage results in improved peripheral nerve function, as evidenced by increased nerve conduction velocity, increased nerve Na+,K+ ATPase activity, and significant amelioration of nerve structural changes.[SUP][4][/SUP] Likewise, C-peptide administration in animals that had C-peptide deficiency (type 1 model) with nephropathy improves renal function and structure; it decreases urinary albumin excretion and prevents or decreases diabetes-induced glomerular changes secondary to mesangial matrix expansion.[SUP][5][/SUP][SUP][6][/SUP][SUP][7][/SUP][SUP][8][/SUP] C-peptide also has been reported to have anti-inflammatory effects as well as aid repair of smooth muscle cells.[SUP][9][/SUP][SUP][10][/SUP] ii
[h=3]Clinical uses of C-peptide testing[edit][/h]

• Patients with diabetes may have their C-peptide levels measured as a means of distinguishing type 1 diabetes from type 2 diabetes or Maturity onset diabetes of the young (MODY).[SUP][11][/SUP] Measuring C-peptide can help to determine how much of their own natural insulin a person is producing as C-peptide is secreted in equimolar amounts to insulin. C-peptide levels are measured instead of insulin levels because C-peptide can assess a person's own insulin secretion even if they receive insulin injections, and because the liver metabolizes a large and variable amount of insulin secreted into the portal vein but does not metabolise C-peptide, meaning blood C-peptide may be a better measure of portal insulin secretion than insulin itself.[SUP][12][/SUP][SUP][13][/SUP] A very low C-peptide confirms Type 1 diabetes and insulin dependence and is associated with high glucose variability, hyperglycaemia and increased complications. The test may be less helpful close to diagnosis, particularly where a patient is overweight and insulin resistant, as levels close to diagnosis in Type 1 diabetes may be high and overlap with those seen in type 2 diabetes.[SUP][14][/SUP]
• Differential diagnosis of hypoglycemia. The test may be used to help determine the cause of hypoglycaemia (low glucose), values will be low if a person has taken an overdose of insulin but not suppressed if hypoglycaemia is due to an insulinoma or sulphonylureas.
• Factitious (or factitial) hypoglycemia may occur secondary to the surreptitious use of insulin. Measuring C-peptide levels will help differentiate a healthy patient from a diabetic one.
• C-peptide may be used for determining the possibility of gastrinomas associated with Multiple Endocrine Neoplasm syndromes (MEN 1). Since a significant number of gastrinomas are associated with MEN involving other hormone producing organs (pancreas, parathyroids, and pituitary), higher levels of C-peptide together with the presence of a gastrinoma suggest that organs besides the stomach may harbor neoplasms.
• C-peptide levels may be checked in women with Polycystic Ovarian Syndrome (PCOS) to help determine degree of insulin resistance.

 

[drtbear1967]

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