drtbear1967
Musclechemistry Board Certified Member
By theguerillachemist[/URL]
In an attempt to bring the latest and greatest stimulant to market, many companies are using Eria Jarensis extract so I want shed some light into this new ingredient. Eria Jarensis extract consists of 2 main constituents that arephenylethylamine(PEA) derivatives. As I've discussed earlier, PEA are pretty much worthless bc 1) it is very quickly metabolized by the enzyme MonoamineOxidase and 2) they are missing the alpha methyl group needed for efficientb inding. These 2 compounds, N-methyl phenylethylamine and N,N-dimethylphenylethylamine also lack the alpha methyl group. Being N-methylated, they may act like hordenine does, binding to monoamine oxidase, which prolongs the effects of other stimulants. Another pathway is that they can increase the production of catecholamines like dopamine and norepinephrine. Either way,these molecules are no where near as strong as DMAA. Being N-methylated, they can cross the BBB more effectively, but even with that, I don't believe these molecules are very strong stimulants. Common doses for this are anywhere from150-250mg. Worth mentioning, there is a 3rd PEA derivative found, N,N,N-trimethyl PEA, which would be quaternary amine(positively charged) whichmay have strong MAO-B inhibition. Eria Jarensis is found in SP250 by gaspariand Dexamine Black by Giant Sports.
In an attempt to bring the latest and greatest stimulant to market, many companies are using Eria Jarensis extract so I want shed some light into this new ingredient. Eria Jarensis extract consists of 2 main constituents that arephenylethylamine(PEA) derivatives. As I've discussed earlier, PEA are pretty much worthless bc 1) it is very quickly metabolized by the enzyme MonoamineOxidase and 2) they are missing the alpha methyl group needed for efficientb inding. These 2 compounds, N-methyl phenylethylamine and N,N-dimethylphenylethylamine also lack the alpha methyl group. Being N-methylated, they may act like hordenine does, binding to monoamine oxidase, which prolongs the effects of other stimulants. Another pathway is that they can increase the production of catecholamines like dopamine and norepinephrine. Either way,these molecules are no where near as strong as DMAA. Being N-methylated, they can cross the BBB more effectively, but even with that, I don't believe these molecules are very strong stimulants. Common doses for this are anywhere from150-250mg. Worth mentioning, there is a 3rd PEA derivative found, N,N,N-trimethyl PEA, which would be quaternary amine(positively charged) whichmay have strong MAO-B inhibition. Eria Jarensis is found in SP250 by gaspariand Dexamine Black by Giant Sports.
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