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Muscles Vs. Tendons

trekrider215

New member
For those of you that haven't read this article, i'm posting it. I don't know who wrote it or I would give them credit.

Muscles vs Tendons
While injecting test increases protein synthesis by roughly 50 times, depending on dose and time, most bodybuilders forget that it will reduce collagen synthesis by more than 50% -- more like 80%, giving you the collagen synthesis rate of a senior citizen. Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal. It's like having the skeletal muscle of a gorilla with the tendons of a very old man.

Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on Winstrol. Guys who lift in the 1-5 rep range while on Winstrol, to baseball players who sprint all out from a stationary position -- Winstrol should be the LAST drug they choose. Most of them like Winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it.

Also, the drugs I mention increase collagen synthesis while also increasing collagen cross-linking integrity, making for a much stronger tendon.

Winstrol, on the other hand, will dramatically increase collagen synthesis, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon.

You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug(s) you choose.

Deca, Equipoise, Anavar, and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen synthesis and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.

While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen synthesis.

To plan a cycle where the goal is to increase skeletal muscle mass/strength while at the same time increase joint/tendon/ligament strength, enough to keep up with the dramatic increase in skeletal muscle, you must choose drugs like Eq, Deca, Anavar, or Primo as the base of your cycle. Testosterone and its esters can be added to your cycle to keep levels within a 'normal' physiological range (ie, 100-200 mg/wk) but must not go above this. Since drugs like eq, deca, anavar and primo will reduce endogenous, natural levels of test, these levels may be maintained with exogenous test in the 100-200 mg/wk range. Test at this dose will not inhibit collagen synthesis, but paradoxically, will help increase it. It is when exogenous testosterone is used > 200 mg/wk that collagen synthesis is inhibited.

Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2. Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, Deca is a very good drug at giving you everything you want -- an increase in collagen synthesis, an increase in skeletal muscle, and increases in bone mass and density. The one thing it does not give you is wood.

Primobolan, @ 5 mg/kg, will increase collagen synthesis by roughly 180% -- less than deca and equipoise but still substantial.

Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca.

Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen synthesis to enhance healing.

These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle Clomid use. Here they are:

Deca: 15 days Equipoise: 14 days Primobolan: 10.5 days

Anavar has a half-life of only 8 hours so it should not pose a problem.

GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen synthesis in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies. From what I've read, hGH at 6 iu/day increased the collagen deposition rate by around 250% in damaged collagen structures. This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.

Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen synthesis -- ie, type III, II, I, procollagen markers. GH just seems to do so most dramatically.

Use of any of these drugs @ supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Skeletal muscle mass gains will not be as dramatic as with large testosterone doses but you have to weigh the risk/reward basis for yourself. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread. It is only to demonstrate that you can increase skeletal muscle and collagen synthesis at the same time with certain AAS -- the decision is up to you.​

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I've managed to keep making small gains on 1cc of Deca, 1cc of test, and 1cc of EQ for quite so time. The Deca and EQ are specifically for tendons and ligaments at that dose
 
I just finished my second 20 week cycle in the last two years and each time I come off my ancles hurt and my for arms ache really bad.gonna run igf1 L3 for as long as I can afford it lmao
 
good write up and yes the absolute hands down best thing to run alongside a steroid cycle to help with tendons is IGF-1 Lr3, we have about half a dozen studies from various publications like pubmed on Insulin-like growth factor-1 promoting the synthesis of cartilage / tendon/ as well as showing an ability to regenerate damaged cartilage tissue.

I will post the studies here if anyone is interested.
 
Composites of chondrocytes and polymerised fibrinwere supplemented with insulin-like growthfactor-I (IGF-I) during the arthroscopic repair offull-thickness cartilage defects in a model of extensiveloss of cartilage in horses.

Repairs facilitated withIGF-I and chondrocyte-fibrin composites, or controldefects treated with chondrocyte-fibrin compositesalone, were compared before death by the clinicalappearance and repeated analysis of synovial fluid,and at termination eight months after surgery bytissue morphology, collagen typing, and biochemicalassays.

The structure of cartilage was evaluatedhistologically by Toluidine Blue reaction and collagentype-I and type-II in situ hybridisation andimmunohistochemistry. Repair tissue wasbiochemically evaluated by DNA assay, proteoglycanquantitation and characterisation, assessment ofcollagen by reverse-phase high-performance liquidchromatography, and collagen typing using cyanogenbromide digestion and peptide separation bypolyacrylamide gel electrophoresis.

The results at eight months showed that theaddition of IGF-I to chondrocyte grafts enhancedchondrogenesis in cartilage defects, includingincorporation into surrounding cartilage. Gross fillingof defects was improved, and the tissue contained ahigher proportion of cells producing type-II collagen.Measurements of collagen type II showed improvedlevels in IGF-I-treated defects, supporting in situhybridisation and immunohistochemical assessments ofthe defects. IGF-I improves the repair capabilities ofchondrocyte-fibrin grafts in large full-thickness repairmodels
 
i know i know...booooooring lol, but hey, I dont have anything better to do ant the moment aside from masturbate but im saving that for later on lol,


Injuries to articular cartilage are common in adults and maylead to the development of osteoarthritis because of thepoor repair response of cartilage.1-4

Despite extensiveresearch, a universally acceptable method for resurfacing ofarticular cartilage has not been reported. Many proceduresfor the transplantation of cartilage have been used in animalstudies and human clinical trials with varying results. Theadvances in cartilage repair achieved by the use of osteochondralallografts and autografts, and periosteal and perichondrialtransplantations alone or in conjunction withmesenchymal or chondrocyte transplantation, have beencomprehensively reviewed.5-7

More recently, the use ofbiological or synthetic tissue-engineered matrices for resurfacingof cartilage has received considerable attention.8-15

The application of in vitro amplified, cryopreserved chondrocytesin the constructs reduces or eliminates the need fora donor site, and malleable constructs can be appliedarthroscopically, further improving patient acceptance. Biologicalmatrices such as hyaluronan, collagen type-I andtype-II sponges, alginate, agarose and fibrin have been usedin vitro to study the metabolism of chondrocytes resultingin an extensive pool of knowledge regarding their functionin these matrices. Additionally, the effects of growth factorson their metabolism have been investigated in many ofthese biological matrices.

15-21 It is likely that some of theseproducts may also be used in vivo as carriers for variousgrowth factors to enhance the repair response of the transplantedcells and the host chondrocytes surrounding thedefect.Several growth factors are known to enhance the synthesisof cartilage matrix.

22-27 In particular, insulin-like growthfactor-I (IGF-I) has specific anabolic effects.28-33 The additionof IGF-I to explants of cartilage or to monolayercultures of chondrocytes increased the synthesis of largeaggregating proteoglycans and type-II collagen, whileinhibiting the degradation and release of proteoglycans. Inexplant cultures, the addition of IGF-I to culture mediumhas also been shown to maintain the mechanical and electromechanicalproperties of the explant cartilage.34

http://www.boneandjoint.org.uk/content/jbjsbr/84-B/2/276.full.pdf
 
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i know i know...booooooring lol, but hey, I dont have anything better to do ant the moment aside from masturbate but im saving that for later on lol,


Injuries to articular cartilage are common in adults and maylead to the development of osteoarthritis because of thepoor repair response of cartilage.1-4

Despite extensiveresearch, a universally acceptable method for resurfacing ofarticular cartilage has not been reported. Many proceduresfor the transplantation of cartilage have been used in animalstudies and human clinical trials with varying results. Theadvances in cartilage repair achieved by the use of osteochondralallografts and autografts, and periosteal and perichondrialtransplantations alone or in conjunction withmesenchymal or chondrocyte transplantation, have beencomprehensively reviewed.5-7

More recently, the use ofbiological or synthetic tissue-engineered matrices for resurfacingof cartilage has received considerable attention.8-15

The application of in vitro amplified, cryopreserved chondrocytesin the constructs reduces or eliminates the need fora donor site, and malleable constructs can be appliedarthroscopically, further improving patient acceptance. Biologicalmatrices such as hyaluronan, collagen type-I andtype-II sponges, alginate, agarose and fibrin have been usedin vitro to study the metabolism of chondrocytes resultingin an extensive pool of knowledge regarding their functionin these matrices. Additionally, the effects of growth factorson their metabolism have been investigated in many ofthese biological matrices.

15-21 It is likely that some of theseproducts may also be used in vivo as carriers for variousgrowth factors to enhance the repair response of the transplantedcells and the host chondrocytes surrounding thedefect.Several growth factors are known to enhance the synthesisof cartilage matrix.

22-27 In particular, insulin-like growthfactor-I (IGF-I) has specific anabolic effects.28-33 The additionof IGF-I to explants of cartilage or to monolayercultures of chondrocytes increased the synthesis of largeaggregating proteoglycans and type-II collagen, whileinhibiting the degradation and release of proteoglycans. Inexplant cultures, the addition of IGF-I to culture mediumhas also been shown to maintain the mechanical and electromechanicalproperties of the explant cartilage.34

http://www.boneandjoint.org.uk/content/jbjsbr/84-B/2/276.full.pdf
Good read I was hitting heavy and working 12 hour days pushing screws threw heavy gauge metal so I know there is real damage I cant pick up a gallon of milk with out a arm wrap.luck gave me 2 weeks off
 
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