Natural Hormones 2

[PUMPED]

Steroid chemical classes, target receptor, cells, and effects of androgens, anabolics, progesterones and estrogen hormones

[TABLE="class: sortable wikitable jquery-tablesorter"]
<tbody>[TR]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Chemical class[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Name[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Abbreviation[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Tissue[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Cells[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Receptor[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Target Tissue[/TH]
[TH="class: headerSort, bgcolor: #F2F2F2, align: center"]Effect[/TH]
[/TR]
[TR]
[TD]androgen[/TD]
[TD]Testosterone[/TD]
[TD][/TD]
[TD]testes[/TD]
[TD]Leydig cells[/TD]
[TD]AR[/TD]
[TD][/TD]
[TD]libido, Anabolic: growth of muscle mass and strength, increased bone density, growth and strength,Virilizing: maturation of sex organs, formation of scrotum, deepening of voice, growth of beard and axillary hair.[/TD]
[/TR]
[TR]
[TD]androgen[/TD]
[TD]Dehydroepiandrosterone[/TD]
[TD]DHEA[/TD]
[TD]testes, ovary, kidney[/TD]
[TD]Zona fasciculataand Zona reticularis cells of kidney
theca cells of ovary
Leydig cellss of testes[/TD]
[TD]AR[/TD]
[TD][/TD]
[TD]Virilization, anabolic[/TD]
[/TR]
[TR]
[TD]androgen[/TD]
[TD]Androstenedione[/TD]
[TD][/TD]
[TD]adrenal glands,gonads[/TD]
[TD][/TD]
[TD]AR[/TD]
[TD][/TD]
[TD]Substrate for estrogen[/TD]
[/TR]
[TR]
[TD]androgen[/TD]
[TD]Dihydrotestosterone[/TD]
[TD]DHT[/TD]
[TD]multiple[/TD]
[TD][/TD]
[TD]AR[/TD]
[TD][/TD]
[TD]5-DHT or DHT is a male reproductive hormone that targets the prostate gland, bulbourethral gland, seminal vesicles, penis and scrotum and promotes growth/mitosis/cell maturation and differentiation. Testosterone is converted to 5-DHT by 5alpha-reductase, usually with in the target tissues of 5-DHT because of the need for high concentrations of 5-dht to produced the physiological effects.[/TD]
[/TR]
[TR]
[TD]mineralocorticoid[/TD]
[TD]Aldosterone[/TD]
[TD][/TD]
[TD]adrenal cortex(zona glomerulosa)[/TD]
[TD][/TD]
[TD]MR[/TD]
[TD][/TD]
[TD]Increase blood volume by reabsorption of sodium in kidneys (primarily)Potassium and H[SUP]+[/SUP] secretion in kidney.[/TD]
[/TR]
[TR]
[TD]estrogen[/TD]
[TD]Estradiol[/TD]
[TD]E[SUB]2[/SUB][/TD]
[TD]females: ovary, males testes[/TD]
[TD]females: granulosa cells, males: Sertoli cell[/TD]
[TD]ER[/TD]
[TD][/TD]
[TD]Females:Structural:

• promote formation of female secondary sex characteristics
• stimulate endometrial growth
• increase uterine growth
• maintenance of blood vessels and skin
• reduce bone resorption
• increase hepatic production of binding proteins

Coagulation:

• increase circulating level of factors 2, 7, 9, 10, antithrombin III, plasminogen
• increase platelet adhesiveness

Fluid balance:

• salt (sodium) and water retention
• increase growth hormone
• increase cortisol, SHBG

Gastrointestinal tract:

• reduce bowel motility
• increase cholesterol in bile

Lung function:

• promote lung function by supporting alveoli.[SUP][6][/SUP]

Males: Prevent apoptosis of germ cells[SUP][7][/SUP][/TD]
[/TR]
[TR]
[TD]estrogen[/TD]
[TD]Estrone[/TD]
[TD][/TD]
[TD]ovary[/TD]
[TD]granulosa cells,Adipocytes[/TD]
[TD]ER[/TD]
[TD][/TD]
[TD][/TD]
[/TR]
[TR]
[TD]estrogen[/TD]
[TD]Estriol[/TD]
[TD]E[SUB]3[/SUB][/TD]
[TD]placenta[/TD]
[TD]syncytiotrophoblast[/TD]
[TD]ER[/TD]
[TD][/TD]
[TD][/TD]
[/TR]
[TR]
[TD]glucocorticoid[/TD]
[TD]Cortisol[/TD]
[TD][/TD]
[TD]adrenal cortex(zona fasciculataand zona reticulariscells)[/TD]
[TD][/TD]
[TD]GR[/TD]
[TD][/TD]
[TD]Stimulation of gluconeogenesisInhibition of glucose uptake in muscle and adipose tissue Mobilization of amino acids from extrahepatic tissues Stimulation of fat breakdown in adipose tissue anti-inflammatory and immunosuppressive[/TD]
[/TR]
[TR]
[TD]progestogen[/TD]
[TD]Progesterone[/TD]
[TD][/TD]
[TD]ovary, adrenal glands, placenta(when pregnant)[/TD]
[TD]Granulosa cellstheca cells of ovary[/TD]
[TD]PR[/TD]
[TD][/TD]
[TD]Support pregnancy:[SUP][8][/SUP]

• Convert endometrium to secretory stage
• Make cervical mucus permeable to sperm
• Inhibit immune response, e.g. towards the human embryo.
• Decrease uterine smooth muscle contractility[SUP][8][/SUP]
• Inhibit lactation
• Inhibit onset of labor
• Support fetal production of adrenal mineralo- and glucosteroids

Other:

• Raise epidermal growth factor-1 levels
• Increase core temperature during ovulation[SUP][9][/SUP]
• Reduce spasm and relax smooth muscle (widen bronchi and regulate mucus)
• Antiinflammatory. Regulate immune response
• Reduce gall-bladder activity[SUP][10][/SUP]
• Normalize blood clotting and vascular tone, zinc and copper levels, cell oxygen levels, and use of fat stores for energy
• Assist in thyroid function and bone growth by osteoblasts
• Resilience in bone, teeth, gums, joint, tendon, ligament and skin healing by regulating collagen
• Nerve function and healing by regulating myelin
• Prevent endometrial cancer by regulating effects of estrogen

[/TD]
[/TR]
[TR]
[TD]secosteroid[/TD]
[TD]Calcitriol (1,25-dihydroxyvitamin D[SUB]3[/SUB])[/TD]
[TD][/TD]
[TD]skin/proximal tubuleof kidneys[/TD]
[TD][/TD]
[TD]VDR[/TD]
[TD][/TD]
[TD]Active form of vitamin D[SUB]3[/SUB]Increase absorption of calcium and phosphate from gastrointestinal tract and kidneys inhibit release of PTH[/TD]
[/TR]
[TR]
[TD]secosteroid[/TD]
[TD]Calcidiol (25-hydroxyvitamin D[SUB]3[/SUB])[/TD]
[TD][/TD]
[TD]skin/proximal tubuleof kidneys[/TD]
[TD][/TD]
[TD]VDR[/TD]
[TD][/TD]
[TD]Inactive form of vitamin D[SUB]3[/SUB]
[/TD]
[/TR]
</tbody>[/TABLE]

 

[gandhisays]

can this be made smaller to fit the page?i have to scroll over to read most of it how u got it npw