MuscleChemistry.com Pharmacokinetics
I will Explain how the half-life of a drug works and then list the various SERM's used During Post Steroid Cycle Therpay and eaches Half-Life For our MuscleChemistry members who arent all too familiar with how this works, so they can better understand what dosage is best and more importantly when to take certain PCT meds whether that is Daily (ED aka Every Day) Or Every Other Day (EOD). Understanding Peak Plasma Concentrations and Rates of Elimination Is Important!
All of this can be translated the same for other drugs, Steroids, or medicines! I just think PCT Post Steroid Cycle Therpay Drug Coverage Is Most Important, more so than the hormones used in your actual steroid cycles, as what good are all those gains made if you arent smart enough to keep them, or what good was that steroid cycle if afterwards you find that you have physical health issues, permenant shut down of exogenous testosterone, or estrogen related side effects causing acne, mood swings, and unwanted breast tissue.
In days to come I will also try covering the following:
Absorbtion Rates
Bioavailability
Clearance
HALF-LIFE Translation : "Time it takes for the plasma concentration or the amount of drug in the body to be reduced by 50%."
Half-Life Delineation, Explanation, Translation, and Interpretation For My Brothers of MuscleChemistry Nation!
Y.T. Presser
By definition, the plasma concentration of a drug is halved after one elimination half-life. Therefore, in each succeeding half-life, less drug is eliminated. After one half-life the amount of drug remaining in the body is 50% after two half-lives 25%, etc. After 4 half-lives the amount of drug (6.25%) is considered to be negligible regarding its therapeutic effects.
The half-life of a drug depends on its clearance and volume of distribution. The elimination half-life is considered to be independent of the amount of drug in the body.
Clinical implications
Half-life determines the length of the drug effect.
It also indicates whether accumulation of the drug will occur under a multiple dosage regimen and it is essential to decide on the appropriate dosing interval.
Related termsElimination rate constant (λ): Fractional rate of drug removal from the body. This rate is constant in first-order kinetics and is independent of drug concentration in the body. λ is the slope of the plasma concentration-time line (on a logarithmic y scale).
Apparent half-life (t1/2):
In some cases, such as for controlled-release preparations, the rate of decline of the drug plasma concentration is not due to elimination alone. Other factors such as absorption rate or distribution rate influence plasma concentration decay.
In such conditions, the observed half-life is called apparent half-life.
Assessment
Vd = volume of distribution
CL = clearance
λ = elimination rate constant = CL/Vd
I will Explain how the half-life of a drug works and then list the various SERM's used During Post Steroid Cycle Therpay and eaches Half-Life For our MuscleChemistry members who arent all too familiar with how this works, so they can better understand what dosage is best and more importantly when to take certain PCT meds whether that is Daily (ED aka Every Day) Or Every Other Day (EOD). Understanding Peak Plasma Concentrations and Rates of Elimination Is Important!
All of this can be translated the same for other drugs, Steroids, or medicines! I just think PCT Post Steroid Cycle Therpay Drug Coverage Is Most Important, more so than the hormones used in your actual steroid cycles, as what good are all those gains made if you arent smart enough to keep them, or what good was that steroid cycle if afterwards you find that you have physical health issues, permenant shut down of exogenous testosterone, or estrogen related side effects causing acne, mood swings, and unwanted breast tissue.
In days to come I will also try covering the following:
Absorbtion Rates
Bioavailability
Clearance
HALF-LIFE Translation : "Time it takes for the plasma concentration or the amount of drug in the body to be reduced by 50%."
Half-Life Delineation, Explanation, Translation, and Interpretation For My Brothers of MuscleChemistry Nation!
Y.T. Presser
By definition, the plasma concentration of a drug is halved after one elimination half-life. Therefore, in each succeeding half-life, less drug is eliminated. After one half-life the amount of drug remaining in the body is 50% after two half-lives 25%, etc. After 4 half-lives the amount of drug (6.25%) is considered to be negligible regarding its therapeutic effects.
The half-life of a drug depends on its clearance and volume of distribution. The elimination half-life is considered to be independent of the amount of drug in the body.
Clinical implications
Half-life determines the length of the drug effect.
It also indicates whether accumulation of the drug will occur under a multiple dosage regimen and it is essential to decide on the appropriate dosing interval.
Related termsElimination rate constant (λ): Fractional rate of drug removal from the body. This rate is constant in first-order kinetics and is independent of drug concentration in the body. λ is the slope of the plasma concentration-time line (on a logarithmic y scale).
Apparent half-life (t1/2):
In some cases, such as for controlled-release preparations, the rate of decline of the drug plasma concentration is not due to elimination alone. Other factors such as absorption rate or distribution rate influence plasma concentration decay.
In such conditions, the observed half-life is called apparent half-life.
Assessment
Vd = volume of distribution
CL = clearance
λ = elimination rate constant = CL/Vd
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