Dean Destructo
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Semax is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties. It is a heptapeptide, synthetic analog of a fragment of adrenocorticotropic hormone(ACTH), ACTH (4-10), of the following structure: Met-Glu-His-Phe-Pro-Gly-Pro. Semax has not been evaluated by the U.S.FDA. It is unscheduled in the U.S. and legal to import by private citizens for personal use.[SUP][1][/SUP]
Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011.[SUP][2][/SUP] Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders,peptic ulcers, optic nerve disease, and to boost the immune system.[SUP][1][/SUP][SUP][1][/SUP][SUP][3][/SUP][SUP][4][/SUP][SUP][5][/SUP]
In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus,[SUP][6][/SUP] and rapidly activates serotonergic and dopaminergic brain systems.[SUP][7][/SUP][SUP][8][/SUP] In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects,[SUP][9][/SUP][SUP][10][/SUP] attenuate the behavioral effects of exposure to chronic stress,[SUP][9][/SUP][SUP][10][/SUP] and potentiate the locomotor activity produced by <small style="font-size: 11.9px;">D</small>-amphetamine.[SUP][8][/SUP][SUP][11][/SUP] As such, it has been suggested that Semax may be effective in the treatment of depression,[SUP][12][/SUP] as well as inattention deficit hyperactivity disorder (ADHD).[SUP][13]
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Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011.[SUP][2][/SUP] Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders,peptic ulcers, optic nerve disease, and to boost the immune system.[SUP][1][/SUP][SUP][1][/SUP][SUP][3][/SUP][SUP][4][/SUP][SUP][5][/SUP]
In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus,[SUP][6][/SUP] and rapidly activates serotonergic and dopaminergic brain systems.[SUP][7][/SUP][SUP][8][/SUP] In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects,[SUP][9][/SUP][SUP][10][/SUP] attenuate the behavioral effects of exposure to chronic stress,[SUP][9][/SUP][SUP][10][/SUP] and potentiate the locomotor activity produced by <small style="font-size: 11.9px;">D</small>-amphetamine.[SUP][8][/SUP][SUP][11][/SUP] As such, it has been suggested that Semax may be effective in the treatment of depression,[SUP][12][/SUP] as well as inattention deficit hyperactivity disorder (ADHD).[SUP][13]