drtbear1967
Musclechemistry Board Certified Member
As most of you guys know, thyroid hormone regulates the metabolism of proteins, fats, and carbs and affects body composition. It determines how "lean" you stay year around(we all have that one friend that eats way more than you and still has abs 24/7.
Sobetirome aka GC-1 is a thyroid hormone receptor(TRbeta) agonist "thyromimetic" (mimics thyroid hormone without being a hormone) that shows some very promising results in the way of fat loss, body comp, ect. Basically, GC-1 acts similarly as T3(thyroid hormone) in the body, but doesn't seem to cause suppression of TSH(thyroid stimulating hormone) levels, a side effect of supplementing with T3/T4/T2. What the studies have shown so far is that GC-1 can increase basal metabolic rate(and fat burning) without causing tachycardia, a side effect from T3. When compared head to head, T3 caused a slightly greater reduction in body weight vs GC-1, but both caused significant increases in energy expenditure and fat loss, while preventing fat mass accumulation. Another benefit noticed with GC-1 was the sparing of bone mineral density, something that is reduced when taking T3. GC-1 recently has been shown to help turn white fat into brown fat. Brown fat is high in UCP-1, a protein that upregulates fat burning via uncoupling. The latest study in mice showed a 50% loss in fat mass in just 2 weeks, as well as a 6-fold improvement in insulin sensitivity.
GC-1 (Sobetirome) is currently in Phase 1a clinical trials for its cholesterol lowering effects. More research is needed, but this definitely looks promising and should hit the bodybuilding circuits soon, if it hasn't already.
Sobetirome aka GC-1 is a thyroid hormone receptor(TRbeta) agonist "thyromimetic" (mimics thyroid hormone without being a hormone) that shows some very promising results in the way of fat loss, body comp, ect. Basically, GC-1 acts similarly as T3(thyroid hormone) in the body, but doesn't seem to cause suppression of TSH(thyroid stimulating hormone) levels, a side effect of supplementing with T3/T4/T2. What the studies have shown so far is that GC-1 can increase basal metabolic rate(and fat burning) without causing tachycardia, a side effect from T3. When compared head to head, T3 caused a slightly greater reduction in body weight vs GC-1, but both caused significant increases in energy expenditure and fat loss, while preventing fat mass accumulation. Another benefit noticed with GC-1 was the sparing of bone mineral density, something that is reduced when taking T3. GC-1 recently has been shown to help turn white fat into brown fat. Brown fat is high in UCP-1, a protein that upregulates fat burning via uncoupling. The latest study in mice showed a 50% loss in fat mass in just 2 weeks, as well as a 6-fold improvement in insulin sensitivity.
GC-1 (Sobetirome) is currently in Phase 1a clinical trials for its cholesterol lowering effects. More research is needed, but this definitely looks promising and should hit the bodybuilding circuits soon, if it hasn't already.
