big in vegas
MuscleChemistry Registered Member
by Scott Welch
The Canadian government recently banned the combination of synephrine and caffeine so fat burners with this combination have been pulled from the market. Synephrine is found in a plant called “Bitter Orange” or “Citrus Aurantium” has introduced many years ago as an ephedra replacement.
Despite recent concerns with the safety of Synephrine, an FDA-funded study found doses of up to 100 mg synephrine/kg body weight which is a massive dose folks, it did not produce developmental toxicity in rats. This and other recent studies on the safety of bitter orange can put weight management product makers at ease that including this ingredient won’t cause consumer harm.
Higher Doses Still Safe
Researchers from FDA and the National Center for Toxicological Research (NCTR) reported doses up to 100 mg p-synephrine/kg body weight did not cause increased fetal death, or gross, visceral or skeletal abnormalities. The dose also did not produce adverse effects on fetal weight .
Synephrine + Caffeine
There was a decrease in maternal weight at 50 mg of Synephrine/kg body weight when given as a 6% synephrine extract with 25 mg caffeine/kg body weight, To put this in perspective folks, a 220 pound man would be taking 5,000 mg of synephrine (typical effective dose for most guys looking to lose weight is is 30 mg) and as it would take a dose of 2,500 mg of caffeine to replicate this result! This is equal to taking over 25 cups of coffee at one time! But in this study, there was also a decrease in maternal weight in the caffeine-only group. However, the researchers reported this decrease in body weight may have been due to decreased food consumption, which was also observed in both groups!
What Does Nutratech Say?
Nutratech is the name of the company that makes “Advantra Z” which is a patented bitter orange extract. They noted also that the dosages used in the study represent 60 to 200 times the daily amount of bitter orange or synephrine typically found in dietary supplements. In this study, rats were dosed daily with one of several different doses of p-synephrine from one of two different extracts. Caffeine was added to some doses.
So What’s The Supplement Genius Saying Next?
For my own supplement stack, 30 mg of synephrine taken on its own or stacked with other stimulants like caffeine, geranium, ephedra etc. makes for an enhanced weight-loss cocktail. Energy levels increase, appetite decreases, and total calorie burning goes up.
The Canadian government recently banned the combination of synephrine and caffeine so fat burners with this combination have been pulled from the market. Synephrine is found in a plant called “Bitter Orange” or “Citrus Aurantium” has introduced many years ago as an ephedra replacement.
Despite recent concerns with the safety of Synephrine, an FDA-funded study found doses of up to 100 mg synephrine/kg body weight which is a massive dose folks, it did not produce developmental toxicity in rats. This and other recent studies on the safety of bitter orange can put weight management product makers at ease that including this ingredient won’t cause consumer harm.
Higher Doses Still Safe
Researchers from FDA and the National Center for Toxicological Research (NCTR) reported doses up to 100 mg p-synephrine/kg body weight did not cause increased fetal death, or gross, visceral or skeletal abnormalities. The dose also did not produce adverse effects on fetal weight .
Synephrine + Caffeine
There was a decrease in maternal weight at 50 mg of Synephrine/kg body weight when given as a 6% synephrine extract with 25 mg caffeine/kg body weight, To put this in perspective folks, a 220 pound man would be taking 5,000 mg of synephrine (typical effective dose for most guys looking to lose weight is is 30 mg) and as it would take a dose of 2,500 mg of caffeine to replicate this result! This is equal to taking over 25 cups of coffee at one time! But in this study, there was also a decrease in maternal weight in the caffeine-only group. However, the researchers reported this decrease in body weight may have been due to decreased food consumption, which was also observed in both groups!
What Does Nutratech Say?
Nutratech is the name of the company that makes “Advantra Z” which is a patented bitter orange extract. They noted also that the dosages used in the study represent 60 to 200 times the daily amount of bitter orange or synephrine typically found in dietary supplements. In this study, rats were dosed daily with one of several different doses of p-synephrine from one of two different extracts. Caffeine was added to some doses.
So What’s The Supplement Genius Saying Next?
For my own supplement stack, 30 mg of synephrine taken on its own or stacked with other stimulants like caffeine, geranium, ephedra etc. makes for an enhanced weight-loss cocktail. Energy levels increase, appetite decreases, and total calorie burning goes up.
FDA Study Shows Bitter Orange Safety
JEFFERSON, Ark.—Despite recent concerns with the safety of bitter orange (Citrus aurantium), an FDA-funded study found doses of up to 100mg p-synephrine/kg body weight, the major component in bitter orange extract, did not produce developmental toxicity in Sprague-Dawley rat fetuses (Birth Defects Res B Dev Reprod Toxicol. 2011 May 18. DOI: 10.1002/bdrb.20308). This and other recent studies on the safety of bitter orange can put weight management product makers at ease that including this ingredient won’t cause consumer harm.
Researchers from FDA and the National Center for Toxicological Research (NCTR) reported doses up to 100 mg p-synephrine/kg body weight did not cause increased fetal death, or gross, visceral or skeletal abnormalities. The dose also did not produce adverse effects on fetal weight
There was a decrease in maternal weight at 50 mg p-synephrine/kg body weight when given as a 6-percent p-synephrine extract with 25 mg caffeine/kg body weight; there was also a decrease in maternal weight in the caffeine-only group. However, the researchers reported this decrease in body weight may have been due to decreased food consumption, which was also observed in these two groups.
Nutratech Inc., maker of Advantra Z, a patented bitter orange extract, noted the dosages used in the study represent 60 to 200 times the daily amount of bitter orange or p-synephrine typically found in dietary supplements.
In this study, Sprague-Dawley rats were dosed daily by gavage with one of several different doses of p-synephrine from one of two different extracts. Caffeine was added to some doses. Animals were sacrificed 20 days after they became pregnant, and fetuses were examined for the presence of various developmental toxic endpoints. NCTR also helped fund this study.
The concern of bitter orange comes from p-synephrine’s resemblance to the active compound in ephedra, which was been banned for use by FDA due to health risks
JEFFERSON, Ark.—Despite recent concerns with the safety of bitter orange (Citrus aurantium), an FDA-funded study found doses of up to 100mg p-synephrine/kg body weight, the major component in bitter orange extract, did not produce developmental toxicity in Sprague-Dawley rat fetuses (Birth Defects Res B Dev Reprod Toxicol. 2011 May 18. DOI: 10.1002/bdrb.20308). This and other recent studies on the safety of bitter orange can put weight management product makers at ease that including this ingredient won’t cause consumer harm.
Researchers from FDA and the National Center for Toxicological Research (NCTR) reported doses up to 100 mg p-synephrine/kg body weight did not cause increased fetal death, or gross, visceral or skeletal abnormalities. The dose also did not produce adverse effects on fetal weight
There was a decrease in maternal weight at 50 mg p-synephrine/kg body weight when given as a 6-percent p-synephrine extract with 25 mg caffeine/kg body weight; there was also a decrease in maternal weight in the caffeine-only group. However, the researchers reported this decrease in body weight may have been due to decreased food consumption, which was also observed in these two groups.
Nutratech Inc., maker of Advantra Z, a patented bitter orange extract, noted the dosages used in the study represent 60 to 200 times the daily amount of bitter orange or p-synephrine typically found in dietary supplements.
In this study, Sprague-Dawley rats were dosed daily by gavage with one of several different doses of p-synephrine from one of two different extracts. Caffeine was added to some doses. Animals were sacrificed 20 days after they became pregnant, and fetuses were examined for the presence of various developmental toxic endpoints. NCTR also helped fund this study.
The concern of bitter orange comes from p-synephrine’s resemblance to the active compound in ephedra, which was been banned for use by FDA due to health risks
