gandhisays
Stage Pro
What do Creatine Supplementation , Myostatin and Insulin-like Growth Factor-1 have in common?
Getting back to the basics by supplementing creatine isnt such a bad idea. After all Creatine is where it all began for many of us who consider ourselves muscle builders, physique changers, fitness freaks and, well you get the point. Remember the first time you used creatine, and that initial 4 or 5 day front-load, yeah you remember lol. Trying to choke down bucket sized scoops of creatine 4 or 5 times daily before finally leveling off to one scoop a day. After that first week you thought to yourself, holy cow whats in that stuff. Your muscle bellies were fully hydrated causing your skin to stretch so thin that you think OH My GOD , I am ripped, as you finally have one single little vein snaking down your forearm in 3d.
Without question your next thought is to run upstairs into your little brother or perhaps sisters room and raid their dresser drawers for the smallest tightest form fitting t-shirt you can find! After all, your ripped now!
Well, here we are 2 days away from the New Year 2018 and Researchers still do not have a clear answer as to the exact proccesses for which Creatine works regarding myogenics. Creatine Research and Studies have also increased in 2017 and do not look as though theyre slowing down any time soon as newly discovered evidence shows creatine to signal alters in Myokine secretions like IGF 1 and Myostatin which both play a major role in the bodies muscle building process.
2017
[h=1]Creatine Supplementation and Skeletal Muscle Metabolism for Building Muscle Mass- Review of the Potential Mechanisms of Action[/h]
Creatine, a very popular supplement among athletic populations, is of growing interest for clinical applications. Since over 90% of creatine is stored in skeletal muscle, the effect of creatine supplementation on muscle metabolism is a widely studied area. While numerous studies over the past few decades have shown that creatine supplementation has many favorable effects on skeletal muscle physiology and metabolism, including enhancing muscle mass (growth/hypertrophy); the underlying mechanisms are poorly understood.
This report reviews studies addressing the mechanisms of action of creatine supplementation on skeletal muscle growth/hypertrophy. Early research proposed that the osmotic effect of creatine supplementation serves as a cellular stressor (osmosensing) that acts as an anabolic stimulus for protein synthesis signal pathways. Other reports indicated that creatine directly affects muscle protein synthesis via modulations of components in the mammalian target of rapamycin (mTOR) pathway. Creatine may also directly affect the myogenic process (formation of muscle tissue), by altering secretions of myokines, such as myostatin and insulin-like growth factor-1, and expressions of myogenic regulatory factors, resulting in enhanced satellite cells mitotic activities and differentiation into myofiber.
Overall, there is still no clear understanding of the mechanisms of action regarding how creatine affects muscle mass/growth, but current evidence suggests it may exert its effects through multiple approaches, with converging impacts on protein synthesis and myogenesis.
Mammalian target of rapamycin; muscle protein synthesis; myogenesis; myogenic regulatory factors; myokines; satellite cells
Getting back to the basics by supplementing creatine isnt such a bad idea. After all Creatine is where it all began for many of us who consider ourselves muscle builders, physique changers, fitness freaks and, well you get the point. Remember the first time you used creatine, and that initial 4 or 5 day front-load, yeah you remember lol. Trying to choke down bucket sized scoops of creatine 4 or 5 times daily before finally leveling off to one scoop a day. After that first week you thought to yourself, holy cow whats in that stuff. Your muscle bellies were fully hydrated causing your skin to stretch so thin that you think OH My GOD , I am ripped, as you finally have one single little vein snaking down your forearm in 3d.
Without question your next thought is to run upstairs into your little brother or perhaps sisters room and raid their dresser drawers for the smallest tightest form fitting t-shirt you can find! After all, your ripped now!
Well, here we are 2 days away from the New Year 2018 and Researchers still do not have a clear answer as to the exact proccesses for which Creatine works regarding myogenics. Creatine Research and Studies have also increased in 2017 and do not look as though theyre slowing down any time soon as newly discovered evidence shows creatine to signal alters in Myokine secretions like IGF 1 and Myostatin which both play a major role in the bodies muscle building process.
2017
[h=1]Creatine Supplementation and Skeletal Muscle Metabolism for Building Muscle Mass- Review of the Potential Mechanisms of Action[/h]
Creatine, a very popular supplement among athletic populations, is of growing interest for clinical applications. Since over 90% of creatine is stored in skeletal muscle, the effect of creatine supplementation on muscle metabolism is a widely studied area. While numerous studies over the past few decades have shown that creatine supplementation has many favorable effects on skeletal muscle physiology and metabolism, including enhancing muscle mass (growth/hypertrophy); the underlying mechanisms are poorly understood.
This report reviews studies addressing the mechanisms of action of creatine supplementation on skeletal muscle growth/hypertrophy. Early research proposed that the osmotic effect of creatine supplementation serves as a cellular stressor (osmosensing) that acts as an anabolic stimulus for protein synthesis signal pathways. Other reports indicated that creatine directly affects muscle protein synthesis via modulations of components in the mammalian target of rapamycin (mTOR) pathway. Creatine may also directly affect the myogenic process (formation of muscle tissue), by altering secretions of myokines, such as myostatin and insulin-like growth factor-1, and expressions of myogenic regulatory factors, resulting in enhanced satellite cells mitotic activities and differentiation into myofiber.
Overall, there is still no clear understanding of the mechanisms of action regarding how creatine affects muscle mass/growth, but current evidence suggests it may exert its effects through multiple approaches, with converging impacts on protein synthesis and myogenesis.
Mammalian target of rapamycin; muscle protein synthesis; myogenesis; myogenic regulatory factors; myokines; satellite cells
