What is Cardarine?
Cardarine (GW-501516) is drug that binds to the PPAR receptor. It was first created by Glaxo Smith Kline and Ligand Pharmaceuticals in 1992. It was discovered that Cardarine, when binding to the PPAR receptor, recruits what is called the coactivator PGC-1α enzyme, which then increases the expression of genes involved in the expenditure of energy. Rats treated with Cardarine were shown to have increased fatty acid metabolism and increased protection against obesity from eating a bad diet, as well as an increased protection from type-2 diabetes. In another study on Rhesus monkeys, cardarine was shown to increase HDL (good cholesterol) and decrease LDL (bad cholesterol). Reasons for this effect appeared to be caused by an increased expression of the cholesterol transporter ABCA1. In other words, cardarine activates the same genetic pathways that are involved in exercise. In addition, cardarine was studied for use in treating cardio disease before its development was halted in 2007.
What is Cardarine Used for?
Cardarine is great for pretty much everything! Incredible endurance benefits from it are probably the most prominent reason to use this product. Not only has it proven to increase endurance in scientific studies, but when you use it for yourself you’d see that the results are nothing short of amazing! If you’re a cardio junkie or just like getting lean, it increase your run times. Your weight lifting sessions will be extended further, you’ll feel energized longer and ultimately get a lot more work done before you walk out of the gym every day.Of course, fat loss is at the top of the list of reasons why many people love Cardarine so much. Striations and veins get more noticeable and your journey to fat loss becomes a lot easier, without the catabolic effects that most fat burners and drugs can have while trimming down. Fat loss from cardarine is a result of increased glucose uptake in skeletal muscle. Essentially, you’re making better use of the nutrients you consume every day and decreasing the amount of carbohydrates or fat stored as adipose tissue. As a result, cardarine is not only fat burning and anti-catabolic, but it’s also a little bit anabolic as well.Cardarine can be stacked with pretty much anything, and it will enhance the results of the cycle. For anabolic-androgenic steroid users who like the drug trenbolone, cardarine is fantastic at combating the negative side effects of “tren” and even enhancing the positive effects.
Dosages
Cardarine will give benefits in both endurance and fat oxidation at 10-15mgs per day for an ideal 8 week cycle; however, 20mg per day for 8-12 weeks is the recommended dose to get you the absolute optimum results in and out of the gym. Cardarine is a banned substance in certain sports, so it’s recommended you are careful with its use if you’re a tested athlete.
Positive Effects and Science
Everyone always asks, where’s the proof that Cardarine help my health? Let’s review the studies guy.
Study #1: http://www.ncbi.nlm.nih.gov/pubmed/24767130
Done by: International Journal of Cardiology
CONCLUSION: Our data indicate that PPARβ/δ activation might be useful to prevent the harmful effects of ER stress induced by saturated fatty acids in the heart by inducing autophagy.
Explanation: In simple terms, this study shows Cardarine was shown to be useful in preventing heart attacks.
Study #2: http://www.ncbi.nlm.nih.gov/pubmed/25063273
Done by: Diabetologia Journal of Medicine
CONCLUSIONS: Overall, these findings indicate that PPARβ/δ prevents ER stress, inflammation and insulin resistance in skeletal muscle cells by activating AMPK.
Explanation: In simple terms, this study shows Cardarine decreases stress on the on your body, decreases
inflammation and helps prevent diabetes.
Side Effects
Cardarine is virtually side effect free. Although some studies have appeared to show a small increase in some cancer rate in mice (not humans), they were done for a very long time with outrageous doses no where near recommended human doses. In some cases giving up to 1000 times (thousand!) the recommended dose. Obviously, if you take 1000 pills of anything, it’s dangerous. Imagine, if you took 1000 pills of Aspirin! You’d be dead after the first 50. So, always take things in perspective. Ultimately there is not enough evidence of this to be conclusive. However, other studies have shown no significant connection to cancer at all, and further studies even showed cardarine to decrease tumor size. Meaning, it helped cure some cancers.
Conclusion
Cardarine is an all around amazing performance enhancer that will give anyone an edge in the gym and “in the kitchen,” no matter what their short or long term goals are. Whether you need it as cycle support to combat side effects of trenbolone, or you want to fully utilize cardarine’s potential to help you reach your goals in building lean muscle and fat loss, it stands above the rest as one of the most helpful fitness and health tools to date.
Author: Jack Steel
Cardarine (GW-501516) is drug that binds to the PPAR receptor. It was first created by Glaxo Smith Kline and Ligand Pharmaceuticals in 1992. It was discovered that Cardarine, when binding to the PPAR receptor, recruits what is called the coactivator PGC-1α enzyme, which then increases the expression of genes involved in the expenditure of energy. Rats treated with Cardarine were shown to have increased fatty acid metabolism and increased protection against obesity from eating a bad diet, as well as an increased protection from type-2 diabetes. In another study on Rhesus monkeys, cardarine was shown to increase HDL (good cholesterol) and decrease LDL (bad cholesterol). Reasons for this effect appeared to be caused by an increased expression of the cholesterol transporter ABCA1. In other words, cardarine activates the same genetic pathways that are involved in exercise. In addition, cardarine was studied for use in treating cardio disease before its development was halted in 2007.
What is Cardarine Used for?
Cardarine is great for pretty much everything! Incredible endurance benefits from it are probably the most prominent reason to use this product. Not only has it proven to increase endurance in scientific studies, but when you use it for yourself you’d see that the results are nothing short of amazing! If you’re a cardio junkie or just like getting lean, it increase your run times. Your weight lifting sessions will be extended further, you’ll feel energized longer and ultimately get a lot more work done before you walk out of the gym every day.Of course, fat loss is at the top of the list of reasons why many people love Cardarine so much. Striations and veins get more noticeable and your journey to fat loss becomes a lot easier, without the catabolic effects that most fat burners and drugs can have while trimming down. Fat loss from cardarine is a result of increased glucose uptake in skeletal muscle. Essentially, you’re making better use of the nutrients you consume every day and decreasing the amount of carbohydrates or fat stored as adipose tissue. As a result, cardarine is not only fat burning and anti-catabolic, but it’s also a little bit anabolic as well.Cardarine can be stacked with pretty much anything, and it will enhance the results of the cycle. For anabolic-androgenic steroid users who like the drug trenbolone, cardarine is fantastic at combating the negative side effects of “tren” and even enhancing the positive effects.
Dosages
Cardarine will give benefits in both endurance and fat oxidation at 10-15mgs per day for an ideal 8 week cycle; however, 20mg per day for 8-12 weeks is the recommended dose to get you the absolute optimum results in and out of the gym. Cardarine is a banned substance in certain sports, so it’s recommended you are careful with its use if you’re a tested athlete.
Positive Effects and Science
Everyone always asks, where’s the proof that Cardarine help my health? Let’s review the studies guy.
Study #1: http://www.ncbi.nlm.nih.gov/pubmed/24767130
Done by: International Journal of Cardiology
CONCLUSION: Our data indicate that PPARβ/δ activation might be useful to prevent the harmful effects of ER stress induced by saturated fatty acids in the heart by inducing autophagy.
Explanation: In simple terms, this study shows Cardarine was shown to be useful in preventing heart attacks.
Study #2: http://www.ncbi.nlm.nih.gov/pubmed/25063273
Done by: Diabetologia Journal of Medicine
CONCLUSIONS: Overall, these findings indicate that PPARβ/δ prevents ER stress, inflammation and insulin resistance in skeletal muscle cells by activating AMPK.
Explanation: In simple terms, this study shows Cardarine decreases stress on the on your body, decreases
inflammation and helps prevent diabetes.
Side Effects
Cardarine is virtually side effect free. Although some studies have appeared to show a small increase in some cancer rate in mice (not humans), they were done for a very long time with outrageous doses no where near recommended human doses. In some cases giving up to 1000 times (thousand!) the recommended dose. Obviously, if you take 1000 pills of anything, it’s dangerous. Imagine, if you took 1000 pills of Aspirin! You’d be dead after the first 50. So, always take things in perspective. Ultimately there is not enough evidence of this to be conclusive. However, other studies have shown no significant connection to cancer at all, and further studies even showed cardarine to decrease tumor size. Meaning, it helped cure some cancers.
Conclusion
Cardarine is an all around amazing performance enhancer that will give anyone an edge in the gym and “in the kitchen,” no matter what their short or long term goals are. Whether you need it as cycle support to combat side effects of trenbolone, or you want to fully utilize cardarine’s potential to help you reach your goals in building lean muscle and fat loss, it stands above the rest as one of the most helpful fitness and health tools to date.
Author: Jack Steel
