guardianactual
MuscleChemistry Registered Member
Triptorelin Structure 5-oxo-D-prolyl-L-histidyl-Ltryptophyl-L-seryl-Ltyrosyl-3-(1H-indol-2-yl)-L-alanylleucyl-L-arginyl-L-prolylglycinamide Brand name Trelstar
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</br> The bodybuilder went to a doctor in September 2008 because he was depressed, had no energy and had lost all interest in sex. He told the doctor he’d been using steroids since he was 21. The guy took 10-week courses. Typically he would inject a daily 25 mg nandrolone and 25 mg stanozolol for the first 8 weeks, and follow it with 2 weeks of 50 mg mesterolone daily [say: primo]. The following week he would take 50 mg clomid daily, and for the last week he’d inject himself three times with 2000 IE hCG. Well, that’s what the doctors reported. Probably the man took hCG first and clomid after. What’s more the doses sound very responsible to us. If bodybuilders tell doctors how much steroids they’ve been using, in our experience you need to triple the doses.
</br>
</br> How many courses the man took each year is also not mentioned in the article. The bodybuilder did jack up his doses from 2005 to 2008. During the 8 weeks that he injected stanozolol and nandrolone, he also started to use boldenone, injecting an average of 50 mg per day for a period of 3 weeks. And that’s where it went wrong, according to the blood tests. The doctors examined the guy in September, but decided to just observe for a few months. A damaged axis often just needs time to recover. But when the doctors examined the bodybuilder’s blood again in January 2009, there had been hardly any improvement.
</br>
</br> The doctors decided to treat the guy with the GnRH analogue triptorelin. GnRH is a hormone that consists of only 10 amino acids. It is produced in the brain by the hypothalamus and stimulates the production of FSH and LH by the pituitary gland. The hormones travel in the blood to the sex glands, where they get these to produce testosterone. The bodybuilder responded immediately to the hormone treatment. Within several minutes the concentration of LH and FSH in his blood had risen.
</br>
</br> The doctors saw the bodybuilder 10 days later. His energy had returned and the testosterone concentration in his blood had risen to 7 ng/ml. Another three weeks later, his testosterone level was still normal, and his libido had returned too. its not one shot pct.....t levels decline after 2wks....its more a replacement for the hcg blast technique, id still serm and use trip day one of pct
</br>
</br> GnRH (Triptorelin) 100mcg Like many chemicals, we want to really pay attention to our dosing. GnRH makes a great jumpstart, probably now the most effective jumpstart chem, because unlike hcg, it stimulates both lh - leutenizing hormone - and FSH - follicle stimulating hormone - to a higher extent and has a much more lasting effect. But much like hcg, dihydrotestosterone, HMB, ect ect, we need to be very careful with our pituitary and avoid hyper-stimulation. We need to pulse it once, at a small dose, simulating the pulse that is normally sent from our brain, and then let our bodies do the rest of the work.
</br>
</br> GnRH is so powerful that large doses (around 4mg), repeated once a month, is being used as a chemical form of castration. This dose is so intense on the pituitary, that it hyper-stimulates, resulting in castration-like levels of testosterone serum in the body. Much like hcg, dosing is delicate, and too much is not a good thing. We need to use GnRH as a restart, one-and-done, and not over-do things because it may have a much more opposite and negative effect.
</br>
</br> Without any further talk, here is my recommendation for use. One single 100mcg dose per cycle, after all esters have cleared the body and you are 100% ready for recovery. hcg should still be used on-cycle, but in my opinion this full-stimulation should be saved for the PCT and recovery phase. Use hcg on cycle to continue simulating lh - leutenizing hormone - , and then GnRH in the post cycle. Studies I have read have seen results from even 600mcg used in a three-day period, and still hpta - hypothalamic-pituitary-testicular axis - function was completely restored, and his hormone levels remained within the normal range during three checkups within the following year. This suggests that the restart will not have the “flare” effect if used at reasonable doses. Another study showed the same effect, with a dose of only one 100mcg injection into a bodybuilder who had been shutdown for 13 years. That said, no more then 100mcg per 4 months. Do not exceed 1mg within a year to avoid the castration-like shutdown of your system. That even gives you room to do it after an 8-week cycle, take the appropriate time off, and then begin another. And for oral-only cycles that are under 8 weeks, save your money, as Triptorelin is not cheap stuff. Better yet, don’t do oral only cycles, as they are a waste of time, but that’s a whole nother fish to fry, which I will do later. How to use it... After your cycle ends w/in a few day before PCT (waiting 4 esters to clear) 3-5 days after you inject 100mcg subq or Trip... Start your planned PCT as IMHO the effects are short lived and will help easy u into PCT.
</br>
</br> Side effects If you use too much or too often you can suffer
</br>
</br> Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh).
</br>
</br> During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy. In contrast, gonadotropin-releasing hormone antagonists do not cause a surge, but a sudden reduction of testosterone levels.
</br>
</br> TRELSTAR™ DEPOT is indicated in the palliative treatment of advanced prostate cancer. It offers an alternative treatment for prostate cancer when orchiectomy or estrogen administration are either not indicated or unacceptable to the patient. Side effects of TRESLSTAR DEPOT: Adverse Event N % Application Site Disorders Injection site pain 5 3.6 Body As A Whole Hot flushes * Pain Leg pain Fatigue 82 3 3 3 58.6 2.1 2.1 2.1 Cardiovascular Hypertension 5 3.6 Central and Peripheral Nervous System Disorders Headache Dizziness 7 2 5.0 1.4 Gastrointestinal Disorders Diarrhea Vomiting 2 3 1.4 2.1 Musculoskeletal System Disorders Skeletal pain 17 12.1 Psychiatric Insomnia Impotence * Emotional lability 3 10 2 2.1 7.1 1.4 Red Blood Cell Disorders Anemia 2 1.4 Skin and Appendages Disorders Pruritus 2 1.4 Urinary System Urinary retention Urinary tract infection 2 2 1.4 Dosage Adjustments: ** Patients with renal or hepatic impairment showed 2- to 4-fold higher exposure than young healthy males. The clinical consequences of this increase, as well as the potential need for dose adjustment, is unknown.
</br>
</br> Sorry if it's a bit unstructured... These are multiple write ups both users & clinical studies.
</br>
</br> The bodybuilder went to a doctor in September 2008 because he was depressed, had no energy and had lost all interest in sex. He told the doctor he’d been using steroids since he was 21. The guy took 10-week courses. Typically he would inject a daily 25 mg nandrolone and 25 mg stanozolol for the first 8 weeks, and follow it with 2 weeks of 50 mg mesterolone daily [say: primo]. The following week he would take 50 mg clomid daily, and for the last week he’d inject himself three times with 2000 IE hCG. Well, that’s what the doctors reported. Probably the man took hCG first and clomid after. What’s more the doses sound very responsible to us. If bodybuilders tell doctors how much steroids they’ve been using, in our experience you need to triple the doses.
</br>
</br> How many courses the man took each year is also not mentioned in the article. The bodybuilder did jack up his doses from 2005 to 2008. During the 8 weeks that he injected stanozolol and nandrolone, he also started to use boldenone, injecting an average of 50 mg per day for a period of 3 weeks. And that’s where it went wrong, according to the blood tests. The doctors examined the guy in September, but decided to just observe for a few months. A damaged axis often just needs time to recover. But when the doctors examined the bodybuilder’s blood again in January 2009, there had been hardly any improvement.
</br>
</br> The doctors decided to treat the guy with the GnRH analogue triptorelin. GnRH is a hormone that consists of only 10 amino acids. It is produced in the brain by the hypothalamus and stimulates the production of FSH and LH by the pituitary gland. The hormones travel in the blood to the sex glands, where they get these to produce testosterone. The bodybuilder responded immediately to the hormone treatment. Within several minutes the concentration of LH and FSH in his blood had risen.
</br>
</br> The doctors saw the bodybuilder 10 days later. His energy had returned and the testosterone concentration in his blood had risen to 7 ng/ml. Another three weeks later, his testosterone level was still normal, and his libido had returned too. its not one shot pct.....t levels decline after 2wks....its more a replacement for the hcg blast technique, id still serm and use trip day one of pct
</br>
</br> GnRH (Triptorelin) 100mcg Like many chemicals, we want to really pay attention to our dosing. GnRH makes a great jumpstart, probably now the most effective jumpstart chem, because unlike hcg, it stimulates both lh - leutenizing hormone - and FSH - follicle stimulating hormone - to a higher extent and has a much more lasting effect. But much like hcg, dihydrotestosterone, HMB, ect ect, we need to be very careful with our pituitary and avoid hyper-stimulation. We need to pulse it once, at a small dose, simulating the pulse that is normally sent from our brain, and then let our bodies do the rest of the work.
</br>
</br> GnRH is so powerful that large doses (around 4mg), repeated once a month, is being used as a chemical form of castration. This dose is so intense on the pituitary, that it hyper-stimulates, resulting in castration-like levels of testosterone serum in the body. Much like hcg, dosing is delicate, and too much is not a good thing. We need to use GnRH as a restart, one-and-done, and not over-do things because it may have a much more opposite and negative effect.
</br>
</br> Without any further talk, here is my recommendation for use. One single 100mcg dose per cycle, after all esters have cleared the body and you are 100% ready for recovery. hcg should still be used on-cycle, but in my opinion this full-stimulation should be saved for the PCT and recovery phase. Use hcg on cycle to continue simulating lh - leutenizing hormone - , and then GnRH in the post cycle. Studies I have read have seen results from even 600mcg used in a three-day period, and still hpta - hypothalamic-pituitary-testicular axis - function was completely restored, and his hormone levels remained within the normal range during three checkups within the following year. This suggests that the restart will not have the “flare” effect if used at reasonable doses. Another study showed the same effect, with a dose of only one 100mcg injection into a bodybuilder who had been shutdown for 13 years. That said, no more then 100mcg per 4 months. Do not exceed 1mg within a year to avoid the castration-like shutdown of your system. That even gives you room to do it after an 8-week cycle, take the appropriate time off, and then begin another. And for oral-only cycles that are under 8 weeks, save your money, as Triptorelin is not cheap stuff. Better yet, don’t do oral only cycles, as they are a waste of time, but that’s a whole nother fish to fry, which I will do later. How to use it... After your cycle ends w/in a few day before PCT (waiting 4 esters to clear) 3-5 days after you inject 100mcg subq or Trip... Start your planned PCT as IMHO the effects are short lived and will help easy u into PCT.
</br>
</br> Side effects If you use too much or too often you can suffer
</br>
</br> Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh).
</br>
</br> During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy. In contrast, gonadotropin-releasing hormone antagonists do not cause a surge, but a sudden reduction of testosterone levels.
</br>
</br> TRELSTAR™ DEPOT is indicated in the palliative treatment of advanced prostate cancer. It offers an alternative treatment for prostate cancer when orchiectomy or estrogen administration are either not indicated or unacceptable to the patient. Side effects of TRESLSTAR DEPOT: Adverse Event N % Application Site Disorders Injection site pain 5 3.6 Body As A Whole Hot flushes * Pain Leg pain Fatigue 82 3 3 3 58.6 2.1 2.1 2.1 Cardiovascular Hypertension 5 3.6 Central and Peripheral Nervous System Disorders Headache Dizziness 7 2 5.0 1.4 Gastrointestinal Disorders Diarrhea Vomiting 2 3 1.4 2.1 Musculoskeletal System Disorders Skeletal pain 17 12.1 Psychiatric Insomnia Impotence * Emotional lability 3 10 2 2.1 7.1 1.4 Red Blood Cell Disorders Anemia 2 1.4 Skin and Appendages Disorders Pruritus 2 1.4 Urinary System Urinary retention Urinary tract infection 2 2 1.4 Dosage Adjustments: ** Patients with renal or hepatic impairment showed 2- to 4-fold higher exposure than young healthy males. The clinical consequences of this increase, as well as the potential need for dose adjustment, is unknown.
</br>
</br> Sorry if it's a bit unstructured... These are multiple write ups both users & clinical studies.
