Femara and nolvadex do two similar yet different things. Femara is an aromatase inhibitor and nolvadex is an anti estrogen. Femara stops test from aromatizing to estrogen, and nolvadex blocks estrogen receptors, but does not stop aromatization or lessen estrogen levels in the body. Most people use Nolvadex to combat gyno with stronger AAS. Femara is very effective from 0.5-2.5mg ed or eod, depending on how your body reacts to estrogenic side effects such as water retention, and gyno. Some negatives to femara would be libido problems, lack of sensitivity at certain doses for some. Aromasin on the other hand is what I usually recommend for people. It is a suicide inibitor amongst estrogen receptors and also is an aromatase inhibitor. There are no negative sides, and it is effective at 12.5mg eod or 12.5mg ed up to 25mg ed. Anymore than that would be overkill. Studies however have shown doses up to 800mg per day in patients with breast cancer with no negative side effects (however this is unecessary for our needs).