myostatin pro peptide(HMP) and follistatin...
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PhD-HappyToHelp
New member
Suadades, could you provide references and calculations for your acvr2b dosage decision? The studies I have seen on mice discuss 10mg+/kg, equating to nearly a gram (or more) per dose for a 75+ kg human. Obviously that is cost prohibitive. I have suspicisions that your dose is very reasonable and justifiable, but I would like to hear your thoughts (and anyone else actually doing this) before I bias everyone with my info.
S
saudades
Guest
Sorry, I can't provide you any reference or calculation on the dosage, only that's what I could afford. I wanted to get at least one full mg of it, but I just didn't have the resources for it. I was aware of the dosage given to the mice, and I knew that to get that same result one would have to take roughly around 4 grams. Since the results of a dosage like that would take me from 210 to well over 300 lbs in only two weeks, I figured that 1 gram would probably be a good dosage, but that's still cost prohibitive so I had to settle for 1 mg--almost got that and got 0.6mg instead ($300 difference, ouch). I also figured that even at that small dosage, there should be effect enough to notice which there definitely was.
PhD-HappyToHelp
New member
Thanks for the info. Didn't realize it was based on economics lol. There is a study with post menopausal women that were given 0.1mg - 3mg/kg, with a 5% effect on weight at the 1 md/kg level after about a month (I think biweekly dosing). So, the mice levels definitely are not necessary.
That being said, even 1mg/kg is over 50 times more than you took. It's odd to me that such a vast range of dosages still has an effect. And, since they didn't report the 0.1mg/kg group results, I assume it was negative. Of course, that's in post-menopausal women, so perhaps there is something to the synergies that I've seen your posts speculate about.
Also, calculations from known myostatin levels in human blood (10-100ng/ml depending on what study you believe) indicate that high ug quantities SHOULD be effective since they should be able to bind all the myostatin in your blood.
Just wish there wasn't so much contradictory info: 50mg/kg still causes a dose-dependent increase in mice (indicating that less doesn't top the effect out), yet 1mg/kg has an effect (granted much less) in human women, while basic chemistry calculations indicate that you only have about 50ug of myostatin in your blood and so you should (depending on the exact affinity of the antibody) be able to neutralize it with 100-200ug antibody. Those numbers span an unconfortably large range...
That being said, even 1mg/kg is over 50 times more than you took. It's odd to me that such a vast range of dosages still has an effect. And, since they didn't report the 0.1mg/kg group results, I assume it was negative. Of course, that's in post-menopausal women, so perhaps there is something to the synergies that I've seen your posts speculate about.
Also, calculations from known myostatin levels in human blood (10-100ng/ml depending on what study you believe) indicate that high ug quantities SHOULD be effective since they should be able to bind all the myostatin in your blood.
Just wish there wasn't so much contradictory info: 50mg/kg still causes a dose-dependent increase in mice (indicating that less doesn't top the effect out), yet 1mg/kg has an effect (granted much less) in human women, while basic chemistry calculations indicate that you only have about 50ug of myostatin in your blood and so you should (depending on the exact affinity of the antibody) be able to neutralize it with 100-200ug antibody. Those numbers span an unconfortably large range...
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know we use to have alot of posts on this, but not latley that i know of anyhow. Welcome to MuscleChemistry.com by the way!!!!
Thnx bro, and if u run it let us know how it works for ya! As for me im 6'3 and maybe 255-65 in that pic.
In
Signed up to MC, purely to let you know I'm keen to find out how you go with the propeptide, the potential for it is unreal! Good luck bro!
Signed up to MC, purely to let you know I'm keen to find out how you go with the propeptide, the potential for it is unreal! Good luck bro!
Ezskanken
Banana
I will log it for sure, as detailed as I can. I know one is probably out there, buti am having a hell of time finding it! :curse: from what I was able to come across, I put together a protocol that I will use soon. I expect to get my Myostatin with in a couple weeks. I will post everything I do with no lies or bs...
So ur running it by itself with no gear as I would imagine that's the sure way to know its working and what's working?
Ezskanken
Banana
Im cruising right now which is retarded of me (1 cycle in my belt notched so far), scheduled for bloods next week. If all is well, blast off and probably wait till week 4 through 6 to start research. 600 test e and 300 deca for 12 maybe 14 weeks. Will end deca 2 weeks before test...
lab_rat
New member
i came to this site by researching acrv2b, it just popped up for sale on the site i started using for peps, not an advertiser so i wont post the name but i found them on steroidology. $115 for 1mg. they are in IL. i have their mt II and ostarine and they both work so i might try the acvr2b like saudades did. biceps/ triceps and then medial delts. maybe a second vial for subq for overall growth.
after looking around i found another site with gdf8 for sale ($88) and reading the description guess what the source is? E. coli!
it is a bizarre world we live in. gila monster poison for diabetes, botulism for wrinkles, E coli for muscle growth. what's next? extract of cockroaches cures cancer and aids?
after looking around i found another site with gdf8 for sale ($88) and reading the description guess what the source is? E. coli!
it is a bizarre world we live in. gila monster poison for diabetes, botulism for wrinkles, E coli for muscle growth. what's next? extract of cockroaches cures cancer and aids?
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lol, dont laugh , its right around the corner brutha,lol
and welcome to MuscleChemistry bro
Rippedgeek
New member
Hi guys
I'm probably going to get my butt kicked for resurrecting a potentially dead thread... but I'm very interested to know what happened to the guys who tried this "miracle" peptide out. Anyone have any decent feedback.
Rippedgeek
I'm probably going to get my butt kicked for resurrecting a potentially dead thread... but I'm very interested to know what happened to the guys who tried this "miracle" peptide out. Anyone have any decent feedback.
Rippedgeek
Buffalo
MuscleChemistry Member
Nah brotha, you just owe us a beer and it's all good.:wave:
Rippedgeek
New member
Haha... I can try and send you a New Zealand beer, but it will probably be stopped by customs... unless, of course, I label it as "Research Beer"... hmm...
So the reason I'm asking is that I am very tempted to try some Myostatin Human Propeptide... but am finding it difficult to locate a decent log with clearly represented results.
Also, and I hope it's OK to ask this... but how would you guys rate "l a b P E"? I've bought one batch of research material from them but have yet to start trying it on my chimp - service, for what it's worth, was very good.
So the reason I'm asking is that I am very tempted to try some Myostatin Human Propeptide... but am finding it difficult to locate a decent log with clearly represented results.
Also, and I hope it's OK to ask this... but how would you guys rate "l a b P E"? I've bought one batch of research material from them but have yet to start trying it on my chimp - service, for what it's worth, was very good.
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