M1t

[Rep]

How are you guys running this??
50mg daily but are you splitting it up in 2 to 3 doses per day?
20mg 3x daily??
Also, any absorption issues with or without food?
Last, how long is usual run time?
Thanks

 

[The Dude]

I simply do 50mg in the morning whenever on non training days and I do it 1 hour preworkout on training days. I haven't noticed any issues with or without food. I'll take a break when my bottle runs out and after the next 10 weeks or so I'm going to come completely off for a few weeks.

 

[Rep]

Most orals can be hugely affected by food in stomach and decrease absorption by over 50%,
I dont have any literature on it. Does anyone know from another site or literature whether food affects absorption or should the drug be dosed 2-3 times per day instead of once per day. Thanks if anyonre knows this. I know dbol needs to be 2-3times per day for better efficacy and on an empty stomach for better absorption,,, if my memeory serves me right???

 

[Boomer]

i run it at 25mg a day hour before training.. pretty much an empty stomach i wouldnt have eatn somthing for about 2.5 hours ... i notice that when done before training my workouts feel like they can go on and on .. no fatigue. on non training days i do it in the morning just to get it out of the way

although i have noticed my gains tapering off so i was thiking about upping my dose for the last week on.

 

[bigghorn]

50-75mg a day and I do it with grapefruit juice..goin all out all by itself ..

 

[big in vegas]

I do it pre-workout as well and I've not eaten a meal for a couple hours prior, I always drink protein pre-workout as well and I know that doesn't affect it, but I don't know about food

 

[Presser]

Most orals can be hugely affected by food in stomach and decrease absorption by over 50%,
I dont have any literature on it. Does anyone know from another site or literature whether food affects absorption or should the drug be dosed 2-3 times per day instead of once per day. Thanks if anyonre knows this. I know dbol needs to be 2-3times per day for better efficacy and on an empty stomach for better absorption,,, if my memeory serves me right???

I always thought things were absorbed best when with food, so the single product isnt lost to pure stomach acid.

 

[Rep]

NO, most of the time, the drugs are best absorbed when stomach is empty. It only helps when taking it by itself causes stomach aches. The minerals and viatamins in food can "bind" with drugs and keep them from being absorbed. If I get geeky, I can look at the kinetic profiles and see exactly which enzyme in the liver is used. Then you can actually take a similair drug, like benadryl or something that will saturate that enzyme which allows a super much better absirption. So if a drug normally has 50% absorption and you increase it to 80%, then you get more bang for your buck!!!

 

[IronJulius]

+ rep for geeky

 

[big in vegas]

I'm glad I don't look into things as much as you, I'd never get anything accomplished, but I know it has it's advantages.

 

[Rep]

Actually I dont. Since Im a clinical Pharm.D. in a trauma center, I am forced to look for drug interactions esp the ones that inhibit or induce these enzymes causing seizure drugs and other dangerous drugs to either be too low or high.

 

[The Dude]

Doesn't grapefruit juice have an enzyme that increases the effectiveness of orals?

 

[big in vegas]

Actually I dont. Since Im a clinical Pharm.D. in a trauma center, I am forced to look for drug interactions esp the ones that inhibit or induce these enzymes causing seizure drugs and other dangerous drugs to either be too low or high.

Ah, I get it

 

[big in vegas]

Doesn't grapefruit juice have an enzyme that increases the effectiveness of orals?

I've always heard that as well

 

[WesleyInman]

Doesn't grapefruit juice have an enzyme that increases the effectiveness of orals?

:thumbsup: